[Summary] Cardiovascular disease ,diabetic nephropathy and diabetic retinopathy are common complications of diabetes ,and are the significant reason of cardiovascular mortality ,end-stage renal disease ,and blindness in adults patients with type 2 diabetes mellitus. At present, the researche on the pathogenesis of diabetic complications mainly focus on oxidative stress and chronic inflammation. In addition, a large number of studies have pointed out that bilirubin has antioxidant and anti-inflammatory effects. Therefore, bilirubin and diabetic complications are closely linked.

Objective To evaluate the clinical efficacy of silybin combined with nucleotides in the treatment of viral hepatitis associated with nonalcoholic fatty liver disease (NAFLD).Methods 88 viral hepatitis patients with NAFLD were randomly selected into the clinical research,and they were divided into groups according to the order of treatment.Among them 44 cases of single number were the control group treated with nucleoside(acid) drugs,44 cases of double number were the observation group treated with silibinincombined silybin combined with nucleoside(acid).The therapeutic effect after the end of the course of treatment were was evaluated.Results The effective rate in the observation group was 90.91％,which that in the control group was 70.45％,the difference was statistically significant (x2 =8.87,P ＜ 0.05).The ALT,AST,r-GGT after treatment of the observation group were (37.14 ± 3.56) U/L,(30.45 ±3.35) U/L,(51.65 ± 3.46) U/L,which were significantly reduced than before treatment(t =8.01,8.72,7.80,all P ＜ 0.05),and the differences were significant compared with the control group (t =7.57,8.34,7.29,all P ＜ 0.05).The TG,TC of blood lipid indexes indices after treatment of the observation group were (1.48 ±0.26) mmol/L,(5.18 ± 0.86)mmol/L,which were significantly lower than those before treatment (t =7.62,8.14,all P ＜ 0.05),and the differences were significant compared with the control group (t =7.10,7.55,all P ＜ 0.05).Conclusion The combination of silybin and nucleotides in the treatment of viral hepatitis with NAFLD has significant effect,can significantly improve the clinical symptoms and liver function indicators,and gradually restore the level of blood lipids,it is worthy of promoting the application.

0.05);the costs were 459.00 yuan,481.68 yuan and 789.48 yuan,respectively,showing significant differences between Group A and Group C or between Group B and Group C(P0.05).CONCLUSION: Group A is preferable in terms of cost-effectiveness,while there was no significant difference between Group A and Group B in cost.

This paper reports the observation on the distribution of succinic dehydrogenase of the cochlea in normal guinea pig. The method we adopted is as follows: The temporal bone was rapidly removed and the apical portion of the cochlea and the round window were perforated after decapitation under the temperature at 0? to 4℃. Incubation solution was infused into the apical portion of the cochlea and flowed out through the round window. The above procedure was carried out within 3 min. Then the specimen was put into incubation solution for 30 min at 37 C. The same infusion pathway from apical hole to round window was adopted, to introduce a cold, buffered formol sucrose solution for fixation. After first fixation by infusing, the cochlea in the fixative was subjected to a vacuum system for 20～30 min, and finally put into refrigerator to complete fixation. The specimen was then decalcified in 10 per cent EDTA, and immersed in 10 and 20 per cent gelation successively for embedding. The frozen sections was cut into 15? thick midmodiolar sections in a cryostat. This observation reveals that the inner and outer cell, the cell of spiral ganglion and the stria vascularis showed a very strong enzyme activity, while the tectorial membrane, the basilar membrane and other cells showed no activity. The results obtained and the methods are discussed.

OBJECTIVE:To provide information for diversified operation of Chinese pharmaceutical retail chain enterprises.METHODS:By means of introducing the concept of commodity management,its effective application in Chinese pharmaceutical retail chain enterprises was analysed.RESULTS&CONCLUSION:Chinese pharmaceutical retail chain enterprises should apply commodity management theory to searching the mode of diversified operation,for improving net sales and market competition ability.

OBJECTIVE:To discuss about the management of Chinese pharmaceutical retail commerce METHODS:According to the analysis of the operation models and existing problems of Chinese pharmaceutical retail commerce,this paper brings forward concrete management strategy RESULTS & CONCLUSION:Chinese government and pharmaceutical retail enterprises should adopt effective management strategy to promote development of Chinese pharmaceutical retail commerce

OBJECTIVE:To provide the concept of management of circulation of commodities for Chinese pharmaceutical retail chain enterprises METHODS:According to the concept of management of circulation of commodities,to analyze its application in Chinese pharmaceutical retail chain enterprises RESULTS &CONCLUSION:Chinese pharmaceutical retail chain enterprises should search a mode of management of circulation of commodities which is appropriate for self-development to promote market competition ability

OBJECTIVE: To discuss the measures for development of pharmaceutical retail chain enterprises in China after access to WTO.METHODS: Practical developing measures were put forward by way of analysing the existing problems in pharmaceutical retail chain enterprises in China .RESULTS: & CONCLUSION:China s pharmaceutical retail chain enterprises should take the following measures perfecting relevent laws and regulations, deciding rational organization and clarifying the post responsibility, extending the business scale of chain stores, bringing in qualified personnel and training staff members, en-hencing the management of storage and delivery centre and intensifying the management of chain drugstores.

OBJECTIVE:To provide suggestions for perfecting the laws and rules of drug circulation in China.METHODS:To collect,classify and analyze the current laws and rules for drug manufacturing enterprices,common merchandising concerns,drug wholesale enterprises,drugs retail enterprises and pharmaceutical retail chain enterprises in the field of drug circula?tion.RESULTS&CONCLUSION:We should perfect the current laws and rules,and form the system of law for circulation of drugs applicable for each trade in the field of drug circulation,on the other hand,we should add the rules for chain trans-management,chain affiliation,merger,association,cooperation,drug electronic commerce etc.

After a description of the connotation and features of ubiquitous information society and the connotation and components of information literacy of medical staff in ubiquitous information society, the approaches were put forward for training and improving the information literacy of medical staff in ubiquitous information society.