Since the tumor necrosis factor-related apoptosis-inducing ligand was found as a suitable agent for anticancer therapies,study on tumor research has been attaching more importance to it.Utilized the progress on the study of TRAIL on pancreatic carcinoma aspect recent years and standed the principle in TRAIL inducing pancreatic carcinoma apoptosis,this article first simply reviewed the resistance theory of TRAIL on pancreatic carcinoma.Following the trail of identified resistance theory,carring the method of increasing TRAIL's sensibility with protein inhibition,signal regulation,ect,some new treatments have been received,which are described along with the antitumor effect of TRAIL combined with mature treatment in pancreatic carcinoma,and simply assessed at last in the article,to provide a reference on the synergistic cytotoxic effects of TRAIL combined with valid drugs on panreatic carcinoma.

The effects of SLG on the immune function of normal and immune-suppressed mice were investigated. The results showed that SLG (50mg/kg, im) could correct the suppressive effect of cyclophosphamide, dexamethasone or prednisolone on spleen and. thymus weight, serum specific antibody level and lymphocyte transformation. SLG could also improve the phagocytic activity of peritoneal macrophages and enhance peripheral blood ANAE+-lymphocyte ratio of mice. No obvious effect of SLG on the normal mice were observed except that it could increase the antibody level of normal mice. The results implicate that SLG may have some immunomodulatory effect.

Objective To compare the performance of 2009 and 2010 reference standards of the United States Clinical and Laboratory Standards Institute(CLSI)in antimicrobial susceptibility for Enterobacteriaceae.Methods The breakpoints of susceptibility for ceftriaxone,ceftazidime and aztreonam in CLSI M100-S19(2009)were used to analyze results of antimicrobial susceptibility of Escherichia coli (308 isolates)and Klebsiella pneumoniae(194 isolates),as well as those revised in M100-S20(2010).Results With both the breakpoints in CLSI M100-S19(2009)and CLSI M100-S20(2010),proportions of antimicmbial resistance of ceftriaxone,ceftazidime and aztreonam for isolates of extended-spectrum β-lactamases(ESBLs)-producing E. coli were 84.2 percent vs.98.0 percent and 84.9 percent vs.98.0percent,respectively:those for isolates of ESBLs negative E. coli were 4.2 percent vs.7.7 percent and 5.6percent vs.8.4 percent,respectively;those for isolates of ESBLs positive Klebsiella spp.were 67.2 percent vs.90.2 percent and 67.2 percent vs.90.2 percent,respectively:and those for isolates of ESBLs negative Klebsiella spp.were 9.8 percent vs.10.6 percent and 10.6 percent vs.10.6 percent,respectively.Conclusions Proportions of antimicrobial resistance for ceftriaxone,ceftazidime and aztreonam with the rcference breakpeints of CLSI M100-S20(2010)increase to various extent,8.8 compared to those with the old ones in 2009.Compared with ESBLs negative isolates,ESBLs positive isolates are affected much more by the breakpeints of CLSI M100-S20(2010).Proportion of affected Klebsiella spp.by the revised breakpoints of CLSI M100-S20(2010)for ceftazidime and aztreonam is higher than that of E. coli with ESBLs positive.

Objective Sanatoriums have many complex business systems,so there is an urgent need for safe,reliable and stable operation of data centers to provide uninterrupted data services for its business systems. Methods Based on Web service heterogeneous system integration technology,data crawling robot technology,data center core technologies related to the data center,data center of sanatoriums was built. Results Sanatorim data center is the foundation on the integration platform of information,it is an effective solution to application integration and data sharing to achieve data consistency,timeliness,completeness,safety,effectiveness and accuracy. Conclusion The relative concentration of data center in the building of sanatorium is necessary in the development of sanatorium.

Embryonal tumors of central nervous system (CNS) are highly invasive malignant tumors that mainly affect infants.Even if the current active treatment strategies are given, the prognosis is still very poor.The 2016 World Health Organization(WHO) classification integrates the genetic information of diseases with histopathology, so as to make the classification and diagnosis of these tumors more accurate.In the new classification, embryonal tumors of CNS include the most common medulloblastoma, and the rare embryonal tumor with multilayered rosettes, C19MC-altered, embryonal tumor with multilayered rosettes, not otherwise specified (NOS), medulloepithelioma, CNS neuroblastoma, CNS ganglioneuroblastoma, CNS embryonal tumor, NOS, atypical teratoid rhabdoid tumor, and CNS embryonal tumor with rhabdoid features.Further study and exploration on the biological nature of these rare brain tumors will provide scientific basis for new treatment methods.

Humans ; Magnetic Resonance Imaging ; Neurosurgery ; trends

Objective To investigate the pathophysiological changes in irradiation-induced heart injury in rats in order to provide preventive and therapeutic strategies for irradiation-induced heart disease(RIHD).Methods Experiments were performed using female Wistar rats with body weight of approximately 220g.12 female Wistar rats were randomly assigned to two groups(sham-irradiated group and irradiated group).Heart of rats was locally irradiated with 60Co ?-ray at a dosage of 20 Gy.During the post-radiation period,the intake of food and activities of the animals were observed daily and the body weight was recorded monthly.On the 120th day after irradiation,myocardial perfusion was tested using real time myocardial contrast echocardiography(RTMCE).On the 180th day after irradiation,the hearts were isolated from the rats of the both groups,and they were perfused with a Langendorff apparatus.Hemodynamic measurements,including peak systolic LV pressure(LVSP),maximal rate of LV pressure rise(LV dp/dtmax)and fall(LV dp/dtmin)were studied.Then the hearts were examined pathologically with HE staining.Results Animals irradiated with single dose of 20Gy locally were apparently in a good condition during the observation period of 180 days.No differences in food intake,physical activities and body weight were observed between irradiated and control animals.However,myocardial blood velocity(beta)of irradiated rats was significantly lower than that of sham irradiated group(P

Objective To study the expression of homocysteine in serum of patients with common malignant tumor,and initially investigate the possibility of serum homocysteine as cancer biomarker.Methods Expression levels of homocysteine and caner biomarkers (CEA,AFP,CA125,CA199) in serum of 180 patients with established malignant tumor and 30 healthy controls (control) were measured,the results of homocysteine were compared with that of the cancer biomarkers based on the cutoff value used in clinic.Results The expression levels of homocysteine was significantly higher in patients with malignant tumor than in controls [(13.89 ± 4.95) μmol/L-(21.40 ± 9.38) μ mol/L vs (11.40 ± 3.13) μmol/L,P ＜ 0.05)].Conclusions The positive predictive rate of homocysteine is higher than the four kind of cancer biomarkers in lung cancer,breast cancer,esophageal cancer.The increase of homocysteine in tumors may be universal,and Homocysteine may be used as cancer biomarker in lung cancer,breast cancer and esophageal cancer.

At the concentrations of 10-8mol/L, 5.5?l0-8mol/L, 10-7mol/L morphine produced a dose-dependent increase of beating rate in cultured rat heart cells with 9%,32%and 81% respectively. The increase was antagonized by opiate antagonist naloxone ( 10-5mol/L ) , but not affected by propranolol ( 10-5mol/L ) which could cancel the positive chronotropy of isoprenaline ( 10-9mol/L ) on the beating cells. The results support the concept that morphine may be a direct effect on myocadium, perhaps through opiate receptors.

Objective TO study the cellullar immunity function and the role of interleukin-6(IL - 6) during trauma and its recovery stage. Methods 14 cases of serious and 28 mild traumatic fractureswere selected to observe the change of T cell proliferation reaction and IL - 6 presentation of concentration inthe liqUid of T cell culture in vitro. Results 57.14% of serious cases presented the depression of cellproliferation, and IL - 6 concentration reduced to 82. 36 pg/ml, which was lower than that in mild traumagroup (183. 07 pg/ml) and control group(472. 90 pg/ml) respectively. There is statistical significance between the two groups. The rate of CD 8 + T cell was increased relatively in the serious group (33. 43% ), andthe ratio of CD 4 + /CD 8 + (1.58 ) was lower than the group of mild trauma (1. 73 ) and control group (1. 76).There is negative relationship between the concentration of IL - 6 in cell proliferation liquid and CD 8 + T cellratio (r = - 0. 438) in those cases. ConcluSion in serious cases, the T cell proliferation was depressed,while the number of CD 8+ cell increased relatively, and IL - 6 expression was decreased.