Objective To study the cautious behaviors of mice under dangerous conditions caused by height. Methods An elevated beard task was designed,in which the mice were employed to get through a horizontally elevated beard. The time of getting through and number of looking-aside behaviors were recorded under different experimental conditions with different elevated height and visual cues. Results The mean time of getting through the elevated board with a height of 60cm was significantly longer than that of 15cm [(22.55±14.64)s Vs (12.16±8.67)s, P<0.05]. The number of looking-aside behaviors decreased from (2.95±1.73) to (1.95± 1.27) , P <0.05 ,when the visual cues on potential danger were controlled. Conclusion The cautious behaviors increase with the height of elevated board and decrease when controlling for the visual cues on potential danger, which indicate a trade-off relationship between the perceived danger and cautious behaviors.

Forty-three cases of malignant tumors with metastases to serous cavites were treated by interventional chemotherapy under ultrasound guidance and monitoring. 43 cases (83 injections) were all successfully operated and followed up. After peritoneoclysis, besides the common side effects of chemotherapyie nausea and vomiting, 3. 8% of the patients had abdominal pain and 75. 5% had abdominal distention. No complication of hemorrhage, infection, drug leakage or organ injury oceurred. It is suggested the method is safe easily to be used especially for the intracavitary chemotherapy of malignaant tumors and deserves to be widely employed.

T-lymphoblastic lymphoma (T-LBL) is a rare form of non-Hodgkin lymphoma (NHL),which is biologically similar to T-acute lymphoblastic leukemia(ALL),and occurs most frequently in childhood and adolescence.T-LBL progresses fast.The treatment of LBL with conventional chemotherapy regimens for NHL has shown relatively low rates of complete remission and of disease-free survival.Now,it is reasonable to treat patients with LBL with the current ALL-type protocols,and hematopoietic stem cell transplantation may yield a more favorable overall survival (OS) in T-LBL patients,especial in relapsed or refractory LBL patients.

Aim To explore the modulation of Salvia miltiorrhiza on hyperpolarization-activated current (Ih) channels in dorsal root ganglion (DRG) neurons of rats and identify the mechanism of Salvia miltiorrhiza in alleviating pain and inhibiting calcium overload. Methods The effect of Salvia miltiorrhiza injection on Ih channels in DRG neurons of rats were examined by using whole-cell patch clamp technique. Results The experimental results showed that the amplitude of Ih evoked by -150 mV was (-1.06±0.18) nA. The Ih could be fitted well into the single kinetics and the time constant of activation, τ was clearly voltage-dependent with τ=(322.14±28.81) ms at -100 mV, decreasing to τ=(62.51±9.78) ms at -150 mV. The reversal potential of Ih was (-35.03±1.12) mV measured from tail currents. But no significant differences were found between the DRG neurons in the absence and presence of Salvia miltiorrhiza injection (10%, 25%, 50%) in the current amplitude, the time constant of activation and the reversal potential. The only difference between the DRG neurons in the absence and presence of Salvia miltiorrhiza injection was the half-activation potential of Ih. In control recordings the half-activation potential was (-106.07±3.59) mV. By comparison, the half-activation potentials changed to (-111.59±3.79) mV (n=31 neurons, P＜0.05), (-119.37±4.96) mV (n=31 neurons, P＜0.05) and (-121.23±3.86) mV (n=31 neurons, P＜0.05) in the presence of 10%, 25%, 50% Salvia miltiorrhiza injection, respectively. Conclusion Only the half-activation potential of Ih in the arthritic and neuropathic rat models shifted in the depolarizing direction, which increased the electrophysiological activity of Ih and made it related to peripheral hyperalgesia. The selective inhibition of Salvia miltiorrhiza on the electrophysiological activity of Ih may be one of the mechanisms underlying its analgesic effects.

BACKGROUND: There has been no definite cause for Bell's palsy. Different kinds of causes and courses always lead to different outcomes. Up to now there has not been to accord on the relationship between assessment of facial muscle function and prognosis of Bell's palsy.OBJECTIVE: To explore the relationship between level diagnosis, blink reflex(BR) , electroneurography(ENoG) and prognosis in order to find the timing for treatment of Bell's palsy.DESIGN: A self-control study.SETTING: Department of otolaryngology, Beihai People's Hospital,Guangxi Zhuang Autonomous Region.PARTICIPANTS: There were 42 cases of Bell's palsy that were in accordance with the diagnosis criteria and hospitalized in the Beihai People's Hospital from January 1989 to December 1999. Thirty-six cases out of the 42 were well documented and thus were studied here.METHODS: Level diagnosis, BR and EnoG test as well as facial muscle assessment were conducted on thirty-six patients with Bell's palsy.RESULTS: Patients with facial function score under 11 and with the lesion at D segment had poor results in BR and ENoG test. The outcome of conservative treatment for these patients was also bad. That would be improved by facial nerve decompression. The results of examination within one month after palsy onset were correlated with prognosis ( P ＞ 0. 05) . Two cases received decompression on the 40th day onset and recovered completely. Two cases Received decompression in the 2nd month, one recovered completely and decompression and recovered partially.CONCLUSION: Patients with the following manifestations may make conplete recovery after conservative treatment: lesion distal to segment D, facial function over 11 marks, presence of R1 wave by BR test in the 1st month and fiber deprivation ＜ 90% by ENoG. Facial nerve decompression should be taken for patients in a condition other than that.

Objective: To explore the feature of theory of mind(ToM) in schizophrenic patients and the influencing factors. Methods: Subjects were 108 patients with schizophrenia, 21 with affective disorders and 21 normal subjects. Picture-story tasks, PANSS and WAIS-R were used to assess the patients' ToM, symptoms and intelligence. Results:It was found that the scores on first-order theory of mind tasks of schizophrenic patients with IQ below 70 were lower than normal subjects'(D = -56.58,P

Objective To investigate the effect of low-intensity ultrasound on intraocular hypertension and its mechanicsm.Methods The intraocular hypertension rabbits were treated with ultrasound.The intraocular pressure(IOP),trabecular meshwork HE staining,EM microscopy,extracellular matrix through immunohistochemistry were performed.Results After treatment,IOP was descended and trabecula interspace was wider than the control eye.The expression of collagen I,laminin and fibronectin was inhibited.Conclusion Low-intensity ultrasound can decrease IOP.It may be related with the change of histologic structure of trabecular meshwork.

Objective: Exploring the developmental vitial moments and process of career identity.Methods: A case subject was administered structured interview and tested by Career Identity and the Related Factors Questionnaire,Chinese Self-Efficacy Scale,QZPS and MBTI-G.Results: There were several vital moments in the process of career identity,such as the first time to think about career identity,and select a major,the first time to choose career and get employed,meet the organizational changes,find a new job again and get promotion.The present crisis of career identity reflected some unresolved problems of previous developmental periods.Conclusion: The individual's objective behavior toward career choice,decision-making,continuous exploration and efforts were of great benefit to career identity.

Objective To investigate whether there are different effects of electric stimulation of vagus nerve,peripheral nerve(sciatic nerve and trigeminal nerve),and motor cortex on pentylenetetrazol (PTZ)induced convulsion in rats.Methods The vagus nerve and sciatic nerve were exposed in rats.The stimulation electrodes were placed on the vagus nerve,sciatic nerve,trigeminal nerve,and motor cortex,respectively.After electric stimulation,PTZ(50 mg/kg)was intraperitoneally injected into the rats.The pattern and latency of the convulsion seizure were observed and recorded.Results Racine's grade Ⅰ-Ⅴ grade convulsion seizure Was present in 9 rats(9/10)in the control group after the injection of PTZ.However,this intensity Was reduced to Ⅰ-Ⅲ grade differentially in all the rats by electric stimulation of the vagus nerve(5/10)or peripheral nerve(6/10 and 5/10).Furthermore,in the group of rats stimulated at motor cortex,there Was completely no convulsion.On the other hand,when pathological changes appeared in cortex or hippocampus(i.e.epileptic model was set up by 7 weeks stimulation),the same stimulation of motor cortex was not able to inhibit the convulsion seizure induced by injection of PTZ and all these rats showed Ⅳ-Ⅴ grade seizure(10/10).Conclusions In physiological condition,all of the four types of stimulation differentially reduced intensity of convulsion seizure triggered by PIZ injection and motor cortex stimulation has the best effect.However.when rats were in pathological status and epileptic nidus appeared in their brains.stimulatiion of motor cortex has no effect on PTZ induced convulsion seizure.

Objective To explore the function and significance of interleukin(IL)-25 in the pathogenesis of inflammatory bowel disease (IBD) through testing its expression in the intestinal mucosal and serum of patients with IBD. Methods Intestinal or colonic mucosal biopsies of 12 patients with ulcerative colitis (UC), 16 patients with Crohn's disease (CD) and 10 healthy controls were collected. The expression of IL-25 at mRNA level was detected by real-time PCR and the situ expression of IL-25 in intestinal mucosa was analyzed with immunohistochemistry. At same time,serum of 20 UC patients, 24 CD patients and 20 controls was collected, and IL-25 concentration in the serum was determined by enzyme-linked immunosorbent assay (ELISA). Results Compared with healthy controls, the expression of IL-25 at mRNA level in inflamed mucosa of CD and UC patients was significantly decreased (P＜0.05), no statistic difference between UC and CD groups (P＞0.05).The immunohistochemistry results indicated that more IL-25 positive cells in normal lamina propria,the expression of IL-25 in mucosal epithelia cells was low, the expression of IL-25 protein in the intestinal or colonic mucosa of UC and CD patients significantly decreased ( P ＜ 0.05), no statistic difference between UC and CD groups (P＞0. 05). ELISA results showed that the level of IL-25 in the serum of UC and CD groups was significantly lower than healthy controls (P ＜ 0.05). Conclusion The expression of IL-25 in the intestinal mucosa and serum of IBD patients was significantly decreased,which suggested that IL-25 expression defects may closely related to the pathogenesis of IBD. IL-25 may be a new target for the IBD treatment.