Objective To explore the healing effect of vacuum sealing drainage (VSD) technique using in treatment of deep burn wound.Methods Patients were selected who hospitalized in our hospital because of burn from June 2014 to May 2016,and divided into the VSD group and silver sulfadiazine (SD-Ag) group.The incidence of wound infection,bacterial culture positive rate and wound visual analogue score (VAS) were compared between two groups of patients in different time after burn,and also compared two groups of patients with wound healing time,and incidence of scar and the scar rating scale of vancouver.Results A total of 80 patients were included in the study,and divided into VSD (n =46) and SD-Ag (n =34) groups.The wound infection rate and bacterial culture positive rate in the VSD group were significantly lower than the SD-Ag group after burn for 7 d,14 d,and 21 d (P ＜ 0.05).Patient's wound pain VAS score in the VSD group was less than SD-Ag group after burn for 7 d,14 d,and 21 d (P ＜0.05).The wound healing time,incidence of scar,and vancouver scar table score in the VSD group were significantly lower than that of SD-Ag group (P ＜ 0.05).Conclusions The use of vacuum sealing drainage of treatment for burn patients can significantly reduce the wound infection,relieve wound pain,promote wound healing,and reduce scar occurred at the same time.

Objective To compare the anesthesia effects of sevoflurane and propofol in extensive hysterectomy patients and the influence on cognitive function.Methods 94 patients of extensive hysterectomy were selected,according to the drawing method they were divided into control group and observation group,47 cases in each group,the patients were given propofol or sevoflurane anesthesia respectively.The postoperative mini-mental state examination(MMSE) score and the incidence of cognitive dysfunction,inflammation factors,stress reaction,hemodynamic,anesthetic effect and complications were observed in the two groups.Results After operation,the MMSE score of the observation group was higher than that of the control group[(25.44±3.18)points vs.(23.96±2.93)points](t=2.346,P=0.021),the incidence rate of cognitive dysfunction in the observation group was lower than that of the control group [2.12%(1/47) vs.12.76%(6/47)],there was satistically significant difference between the two groups(χ2=3.858,P=0.049 5).The inflammatory factors,stress reaction and hemodynamic index of the observation group were better than those of the control group(all P<0.05).The spontaneous breathing recovery time,open time,extubation time of the observation group were less than those of the control group [(6.19±0.77)min vs.(8.75±1.09)min,(6.89±0.86)min vs.(9.36±1.17)min,(9.47±1.18)min vs.(11.26±1.43)min],there were satistically significant differences between the two groups(t=13.150,11.661,6.619,P=0.000,0.000,0.000).The complication rate had no difference between the two groups(P>0.05).Conclusion The effect of sevoflurane on cognitive function in patients with extensive hysterectomy is less than propofol,and the anesthesia effect is more precisely.

Ocular neovascularization,abnormal formation of new vessels from pre-existing capillaries,is a special pathologic change of many ocular diseases,including diabetic retinopathy and retinopathy of prematurity,etc..Ocular neovascular diseases comprise the common causes of blindness in millions of people.Recent studies showed that kringle domains from many endogenous proteins inhibit the proliferation and migration of endothelial cells in vitro and neovascular formation in vivo.Hence kringle domain with conservative structure has been considered as a potential inhibitor of neovascularization.The update studies on antiangiogenic kringle domains and its inhibition on ocular neovascularization were summarized.

Objective To observe the clinical efficacy of traditional Chinese medicine dialectical therapy and Western medicine in the treatment of the threatened abortion with intrauterine blood.Methods 80 patients were divided into the control group and observation group randomly according to digital table method.There were 40 cases in each group.The observation group was given medicine of improving the function of kidney,spleen and stomach.This medicine was taken for twice a day of 500mL.The patients in the two groups were taken dydrogesterone tablets.An oral starting dose of 4 dydrogesterone tablets was given.Each tablets content 10mg drugs.Then dydrogesterone was taken every 8 hours till symptoms of vaginal bleeding stopped.The patients in the two groups took 100mg vitamin E twice a day.5mg folic acid was taken twice daily.The clinical efficacy and adverse reactions were studied and compared.Results In the control group,9 patients healed.10 cases showed markedly effective.10 cases had effect. 11 cases showed no effect.The total effective rate was 72.5%.In the observation group,10 cases were cured.10 cases showed markedly effective.17 cases had effect.3 cases had no effect.The total effective rate was 92.5%.The total effective rate in the observation group was better than that of the control group (χ2 =5.54,P<0.05).Compared with prior treatment, hemorrhage area were deduced in the two groups ( t =1.54, P <0.05 ) .After treatment, the hemorrhage area in the two groups had significant difference(t =4.32,6.21,all P <0.05).Conclusion The Chinese medicine and Western medicine on the treatment of threatened abortion intrauterine hematoma showed higher total efficiency rate and had no adverse reactions.The clinical program was worth of further study and use.

Objective: To study the relationship between the activation of hepatic stellate cell(HSC) and the early stage of liver fibrosis in experimental diabetic tree shrews.Methods: Tree shrews were divided randomly into normal control group and streptozocin(STZ)-treated group.STZ-treated animals were then divided into diabetic group and STZ control group.ALT,AST,Type Ⅳ collagen(Ⅳ-C),Laminin(LN) and Hyaluronic acid(HA) were detected respectively before and after modelling.Liver biopsy was performed at the end of the experiment(8th week).All of the liver specimens were observed in light microscope and transmission electron microscope.?-smooth muscle actin(?-SMA) was detected by immunohistochemistry and computer image analysis system.Results: Early fibrosis of the liver in diabetic tree shrews can be found by both light and electron microscope.There were some ?-SMA positive HSCs,namely,activated HSCs could be observed in the liver of diabetic group but not in other two groups.The expression of ?-SMA increased significantly in the liver of diabetic group as compared with that of other two groups.In addition,the level of expression of ?-SMA was positively correlated with the collagen area density in diabetic group.Conclusion HSC may play an important role in the development and aggravation of liver fibrosis in diabetic tree shrews.

It is prevalent that patients waiting too long but receiving little service in the out-patient department in general hospital nowadays.To solve this problem,we had analyzed its current service process according to BPR(business process reengineering) theory in enterprise,and reengineered the service process in specialized clinic by means of cutting waste,simplifying steps,merging works and using modern information.We established the renal disease specialized clinic,which had practiced for three years and "one station service" has been achieved.The specialized clinic provides much convenience to patients.

Objective To investigate the clinical changes,alterations of electromyography(EMG) and serum-correlated enzyme in statins-associated myopathy.Methods The clinical trait,alterations of EMG and creatases were analyzed in 5 patients with statins-associated myopathy.Results The average age of 5 patients was 60 years old.They took statins from 2 weeks to 2 years and 2 cases of them also took other medicines.4 patiens felt general pain or pain of inferior extremities.3 patients felt limb hypodynamia and 2 patients had mild muscle weakness.3 patients had muscle haphalgesia.The values of creatine kinase in all the cases were increased to different degree.EMG examination was performed in 2 patients.The result of 1 case was normal and the other case was myogenic change.The symptoms of myopathy were nearly recoverd after withdrawal for 2～3 weeks.Conclusions The statins-associated myopathy is not rare in clinic.Old patients or the patients with other foundational diseases have more chance to suffer this disease.But the prognosis is good after in time withdrawal of statins.

OBJECTIVE To discuss the occupational hazard factors and protection measures of Central Supply Unit.METHODS The occupational hazard factors in the Central Supply Unit were analyzed and some suggestion on the occupational protections to decrease occupational risk was done.RESULTS It is necessary to give some special training about the occupational safety,reinforce the precaution of occupational hazard with regard to biology,physics,chemistry and motor function to establish some protection and countermeasures.CONCLUSIONS The pertinent occupational protection strategy according to the actual hazard factors is more efficient and more benefit for high quality management of Central Supply Unit which will enhance the standardization,quality and working efficiency,and ensure the work safety and quality.

Objective:To explore the reliability, availability and security of peel-away plastic film sheath combination of ureteroscopy pneumatic lithotripsy treatment of female lower segment complexity ureteral calculi.Methods: The treatment group(40 cases) used peel-away plastic film sheath establish a bridge sheath channel between the urethra, bladder and the ureteral opening, combining under ureteroscopy pneumatic lithotripsy treatment. The control group(40 cases) with traditional under ureteroscopy pneumatic lithotripsy treatment. The clinical data of two groups of patients were analyzed.Results: The cure rate of the treatment group was significantly higher than the control group(x2=5.54,P<0.05); and the stones operation time, the bleeding, hospital stays and hospital costs was much better than control group; the complications of surgery (except the ureteral perforation) was significantly less than that of control group.Conclusion: Treatment of female lower segment complexity ureteral calculi by using the peel-away plastic film sheath establish a bridge sheath channel between the urethra, bladder and the ureteral opening, combining under ureteroscopy pneumatic lithotripsy treatment, with safe, convenient, practical, low cost, little injury, fewer complications, etc. was worthy of clinical application.

Objective To explore the clinical effect of trimetazidine in the treatment of coronary heart disease(CHD)patients with heart failure.Methods 80 CHD patients with heart failure cases in our hospital from April 2015 to January 2016 were selected as the research subjects.According to the random lottery method,they were divided into two groups.The control group(n =40)adopted routine comprehensive treatment,the treatment group(n =40)was given trimetazidine on the basis of conventional treatment.The clinical curative effect and heart function index before and after the treatment,exercise tolerance and the change of vascular endothelial function were compared between the two groups.Results The total effective rate of the treatment group was 97.50%(39 /40),which was higher than 77.50%(31 /40)of the control group(χ2 =3.98,P =3.98).After treatment,the systolic blood pressure, left ventricular end systolic diameter and left ventricular end -diastolic diameter in the treatment group were less than the control group,while the left ventricular ejection fraction was greater than the control group,the differences between the two groups were statistically significant (all P <0.01 ),the above index before treatment had no statistically significant differences (all P >0.05 ).The 6 min walking distance of the treatment group after treatment was (375.67 ±28.48)m,which of the control group was (306.18 ±25.71)m,the difference was statistically significant (t =11.451,P =11.451),and the 6 min walking distance before treatment had no statistically significant difference (t =0.013,P =0.013).In the treatment group after treatment,the vascular endothelial function index was (2.32 ± 0.36 )mg/L,which of the control group was (2.95 ±0.16 )mg/L,the difference was statistically significant (t =10.114,P =10.114),while the two groups before treatment had no statistically significant difference in endothelial function index (t =0.126,P =0.126).Conclusion The clinical effect of trimetazidine in the treatment of CHD patients with heart failure is sure,and it can effectively relieve symptoms of heart failure patients,improve the cardiac function,improve their exercise tolerance,which can be used as an ideal drug in CHD patients with heart failure.