Resistance of Plasmodium falciparum (Pf) and P. vivax (Pv) to standard antimalarials is widespread in Papua New Guinea (PNG). The objective of the study was to assess the rate of clinical treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province. 179 patients presenting with symptoms and signs of malaria and with Pf (144 patients), Pv (18 patients), P. malariae (Pm) (7 patients) or mixed infection (10 patients) were included. 86 were treated with AQ, 88 with CQ and 5 with Q+SP. 21/179 patients (12%) were not cured or had a recrudescence of symptoms associated with parasitaemia in the 28 days following treatment, 14% after AQ, 10% after CQ and 0% after Q+SP. The proportion of TF was higher (17%) when the analysis population included only the 108 subjects who had a complete follow-up, especially for failure with Pf following AQ treatment (26%). During the 28 days of follow-up, RII or RIII level of resistance in Pf was detected in 55% of the subjects treated with amodiaquine, 30% of those treated with chloroquine and 0% of those treated with quinine+SP. Of the Pv or Pm parasites only one Pv was found to be RII resistant to CQ in the 28-day test. In vitro resistance of Pf to CQ was higher than to AQ (50% versus 27% of 36 parasite samples that grew successfully). The level of TF and parasitological resistance to standard antimalarial drugs was lower in this area than in urban settings, where drugs are more easily available. AQ performed less well than CQ but the difference is likely to be due to the age of the users, ie, their level of immunity, AQ being the first-line drug for young children. These results provided support for the recent change in the policy for the standard treatment of uncomplicated malaria in PNG from AQ or CQ to the combination of AQ+SP or CQ+SP, a recommendation aimed at slowing down the spread of multidrug resistance.
upper case pea ; Status post ; therapeutic aspects ; Cancer resistance to treatment ; Upper case queue

Aged ; Anxiety ; Health Status ; Humans ; Nurses ; Stress Disorders, Post-Traumatic/epidemiology* ; Workplace Violence

BACKGROUND: Resilient individuals have a comprehensive ability to adapt to various life circumstances. Psychological resilience predicts an individual’s physiological response to stress. The 10-item Connor-Davidson Resilience Scale (CD-RISC) is a widely used measure to quantify the level of self-perceived resilience. This study examined the psychometric properties of a Korean version of the 10-item Connor-Davidson Resilience Scale (10-item K-CD-RISC) on workers in Gumi, South Korea, exposed to hydrofluoric acid (HF). METHODS: The questionnaires included the 10-item K-CD-RISC and Beck Anxiety Inventor (BAI), the Impact of Event Scale-Revised-Korean version (IES-R-K), the Rosen-berg Self Esteem Scale (RSES), the Center for Epidemiologic Studies-Depression Scale (CES-D), and the Perceived Stress Scale (PSS). These were randomly distributed at 237 workplaces near the HF-spill site, in the Gumi 4 complex. The responses of 991 (67.3%) workers were analyzed. RESULTS: The exploratory factor analysis shown that a single-factor model was consistent with the original design of the 10-item CD-RISC. The scale also demonstrated good internal consistency (Cronbach’s alpha = 0.95). Scores on the scale reflected different levels of resilience with respect to personal factors (age, gender, marital status, and education and income levels) that are thought to be differentiated. Differences of resilience were also reflected by psychiatric symptoms (anxiety and depression). Moreover, the total score of scale positively correlated with RSES, whereas the IES-R-K, BAI, CES-D, and the PSS negatively correlated with the 10-item K-CD-RISC. CONCLUSIONS: The 10-item K-CD-RISC has good psychometric properties and is applicable for victims exposed to noxious chemical such as HF.
Anxiety ; Education ; Gyeongsangbuk-do ; Humans ; Hydrofluoric Acid ; Inventors ; Korea ; Marital Status ; Psychometrics ; Resilience, Psychological ; Self Concept ; Stress Disorders, Post-Traumatic

OBJECTIVE: To compare and analyze the mental status of medical staff between Orthopedics Department who treated the victims in the earthquake and other surgical departments who did not treat the victims in the earthquake, and to provide evidence for psychological prevention and intervention in the earthquake aids. METHODS: Cross-sectional study was used to choose staff in the Orthopedics Department who treated the victims and other surgical departments who did not treat victims in the earthquake as eligible subject with convenient sampling. The research tool is Symptom Checklist-90. The questionnaire was done by participants with the same psychological instruction. Data were analyzed by SPSS16.0. RESULTS: The scores in somatization, depression,anxiety and opposition, phobic anxiety in the orthopedic staff were significantly higher than those of the other surgical staff (P < 0.05). CONCLUSION There is disorder in mental health of medical staff in Orthopedics Department and mental intervention is needed.
Adult ; China ; Cross-Sectional Studies ; Earthquakes ; Female ; Humans ; Male ; Medical Staff ; psychology ; Orthopedics ; Psychiatric Status Rating Scales ; Stress Disorders, Post-Traumatic ; psychology ; Surveys and Questionnaires

It is very difficult to identify the relationships between tangle events and accompanied mental disorders. There are often different descriptions of the same controversial conclusion. This thesis introduce the conception of contribute degree and discusses the causality of tangle events and accompanied mental disorders in forensic mental trauma assessments.
Forensic Psychiatry/methods* ; Humans ; Life Change Events ; Mental Disorders/psychology* ; Psychiatric Status Rating Scales ; Schizophrenia/etiology* ; Socioeconomic Factors ; Stress Disorders, Post-Traumatic/psychology* ; Wounds and Injuries/complications*

PURPOSE: Traumatic events and adverse stressful experiences are major etiological factors in a wide variety of physical and mental disorders. Developing psychological instruments that can be easily administered and that have good psychometric properties have become an integral part for research and practice. This study investigated the reliability and validity of the Korean version of the Lifetime Stressor Checklist-Revised (LSC-R) in a consecutive sample of psychiatric outpatients. The LSC-R is a 30-item self-reporting questionnaire examining lifetime traumatic and non-traumatic stressors. MATERIALS AND METHODS: A final sample of 258 outpatients with anxiety or depressive disorders was recruited at the psychiatric department of a university-affiliated teaching hospital. Self-reported data included the Life Events Checklist (LEC), the Zung Self-Rating Depression and Anxiety Scales, and the Impact of Events Scale-Revised, in addition to the LSC-R. A convenience sample of 50 college students completed the LSC-R on two occasions separated by a three week-interval for test-retest reliability. RESULTS: Mean kappa for temporal stability was high (κ=0.651) and Cronbach alpha was moderate (α=0.724). Convergent validity was excellent with corresponding items on the LEC. Concurrent validity was good for symptoms of post-traumatic stress disorder, depression, and anxiety. An exploratory factor analysis revealed that 11 factors explained 64.3 % of the total variance. CONCLUSION: This study demonstrated good psychometric properties of the Korean version of the LSC-R, further supporting its use in clinical research and practice with a Korean speaking population.
Adult ; Anxiety/*diagnosis/epidemiology ; *Checklist ; Depression/diagnosis/epidemiology ; Depressive Disorder/*diagnosis/epidemiology ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Outpatients ; Psychiatric Status Rating Scales ; Psychometrics ; Reproducibility of Results ; Republic of Korea/epidemiology ; Stress Disorders, Post-Traumatic/*diagnosis/epidemiology ; *Surveys and Questionnaires

This study prospectively examined the relationships among cognitive factors and severity of Posttraumatic stress disorder (PTSD) symptoms in female victims of sexual violence. Thirty-eight victims of sexual violence recruited from Center for Women Victims of Sexual and Domestic Violence at Ajou University Hospital. Cognitive factors and PTSD symptom were assessed within 4 months of sexual violence and 25 victims were followed-up 1 month after initial assessment. Repeated-measured ANOVA revealed that PTSD incidence and severity decreased over the month (F [1, 21]=6.61). Particularly, avoidant symptoms might decrease earlier than other PTSD symptoms (F [1, 21]=5.92). This study also showed the significant relationship between early negative trauma-related thoughts and subsequent PTSD severity. Shame and guilt proneness had significant cross-sectional correlations with PTSD severity, but did not show associations when depression severity is controlled. Our results suggest that avoidant symptoms might decrease earlier than other PTSD symptoms during the acute phase and that cognitive appraisals concerning the dangerousness of the world seem to play an important role in the maintenance of PTSD (r=0.499, P<0.05).
Adolescent ; Adult ; *Cognition ; Cross-Sectional Studies ; Depression/diagnosis/etiology ; Female ; Follow-Up Studies ; Humans ; Pilot Projects ; Prospective Studies ; Psychiatric Status Rating Scales ; Questionnaires ; Severity of Illness Index ; *Sex Offenses ; Stress Disorders, Post-Traumatic/*diagnosis/etiology ; Women ; Young Adult

OBJECTIVES: The purpose of this study was to compare the physical and mental health status of disaster victims according to disaster types, such as a typhoon disaster and an oil spill disaster, and to suggest adequate health care services for them. METHODS: A total of 484 people who suffered disasters were selected for this study, and data were collected from July to August, 2008. The data-set for this study included 286 victims of typhoon disasters in Jeju and Jeollanamdo district in South Korea, and 198 victims of the oil spill disaster in Taean. Physical health status was measured using revised Patient Health Questionnaire and mental health status was measured using the Korean version of 'Post-traumatic Diagnostic Scale'. RESULTS: According to the comparative analyses of typhoon disaster victims and oil spill disaster victims, poorer physical health outcomes were shown among the oil spill disaster victims when compared to the typhoon disaster victims. Also, the oil spill disaster victims showed symptoms of depression, anxiety, and post-traumatic stress disorder, at rates higher than those found among the typhoon disaster victims. CONCLUSIONS: These findings suggest that there is a need to provide adequate physical and mental health-related care services for oil spill disaster victims. The seriousness of oil spill disaster should be realized and reconsidered in developing recovery strategies and disaster preparedness for physical and mental health services.
Adult ; Anxiety/etiology ; *Cyclonic Storms ; Data Collection ; Data Interpretation, Statistical ; Depression/etiology ; *Disasters ; Education ; Female ; *Health Status ; Humans ; Male ; *Mental Health ; Middle Aged ; Republic of Korea ; Research ; Sampling Studies ; Stress Disorders, Post-Traumatic/etiology

OBJECTIVES: This study was designed to assess the epidemiology of DSM-IV posttraumatic stress disorder(PTSD), including information on lifetime and current prevalence, the kinds of traumas most often associated with PTSD, and sociodemographic correlates. METHOD: For this survey, an urban area with total population of 611,921 persons was chosen. Modified version of traumatic event checklist and Clinician Administered PTSD Scale were administrated to a representative sample of 850 persons aged 15 to 65 years above through home visiting. RESULTS: The lifetime and current prevalence of PTSD in survey area was 4.71% and 2.12%. the lifetime and current prevalence in male and female were of no significant statistical differences(p>.05). And the lifetime prevalence by age, and education were of no significant statistical differences. Only the lifetime prevalence by marital status was of significant statistical differences(p<0.001). The lifetime prevalence to any traumatic exposure was 78.79%. Sudden unexpected death of a close person was the most prevalent traumatic event(51.06%). Among the traumas, natural disaster, fire and explosion, motor vehicle accident, serious accident at work or home, physical assault, assault with a weapon, combat, life-threatening illness, and serious injury to death you caused to someone else were more commonly associated with male sex, and sexual assault was more commonly associated with female sex. The traumas commonly associated with PTSD were natural disaster, fire and explosion, motor vehicle accident, serious accident at work or home, physical assault, sexual assault, combat, and life-threatening illness. CONCLUSION: The lifetime and current prevalence in survey area were lower than those of previous studies. This study found differences between men and women on the type of trauma experienced, and the type of trauma associated with PTSD. Future epidemiological studies to assess PTSD from all lifetime traumas rather than from only a small number of retrospectively reported ones will be required, and larger sample size covering the country will be required for better estimation.
Checklist ; Diagnostic and Statistical Manual of Mental Disorders ; Disasters ; Education ; Epidemiologic Studies* ; Epidemiology ; Explosions ; Female ; Fires ; House Calls ; Humans ; Male ; Marital Status ; Motor Vehicles ; Prevalence ; Retrospective Studies ; Sample Size ; Stress Disorders, Post-Traumatic* ; Weapons

The Symptom Checklist - Post-Traumatic Stress Disorder Scale (SCL-PTSD), also known as Crime-Related PTSD Scale has been validated in survivors of interpersonal trauma in the general population. However, the psychometric properties have not been investigated in a clinical setting for patients with PTSD from diverse traumatic events. This study investigates the reliability and validity of the Korean version of the SCL-PTSD among 104 psychiatric outpatients with PTSD, caused by interpersonal (n = 50) or non-interpersonal trauma (n = 54). Self-report data of the SCL-PTSD, Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Impact of Events Scale-Revised (IES-R) were gathered. The Korean version of the SCL-PTSD showed excellent internal consistency and moderate-to-good four-week temporal stability in both the interpersonal and non-interpersonal trauma groups. In comparison with other diagnostic groups, the scores of the SCL-PTSD were significantly higher compared to those of adjustment disorder, depression, other anxiety disorders, and schizophrenia, demonstrating its criteria-related validity. Convergent validity was confirmed because the scores of the SCL-PTSD were significantly correlated with BDI, SAI and TAI scores. Concurrent validity was demonstrated by significant correlation with the IES-R score. This study demonstrated the favorable psychometric prosperities of the Korean version of the SCL-PTSD, supporting its use in clinical research and practice.
Adolescent ; Adult ; Anxiety Disorders/diagnosis ; Asian Continental Ancestry Group ; Cross-Cultural Comparison ; Depression/diagnosis ; Female ; Humans ; Male ; Middle Aged ; *Program Evaluation ; Psychiatric Status Rating Scales ; Reproducibility of Results ; Republic of Korea ; Stress Disorders, Post-Traumatic/*diagnosis/pathology ; Young Adult