Background and Aim: The traditional herbal formulation of “Sendeng- 4”have been used to treat ulcers. The wound healing activity of traditional herbal formulations (Sendeng-4) containing Acacia catechu Willd (FamilyFabaceae), Terminalia chebula Retz, Terminalia bellarice (Family Combretaceae), Gardenia jasminoides (family Rubiaceae). We were prepared lotion of “Sendeng-4” was evaluated for its wound healing potential of incision wound models in mice’s. Material and Methods: Healthy inbred white mice’s were weighing 20-22 used for the study. The animals were randomly divided into two groups(n= 10) in all the models. The mice’swere anesthetized ketamine (12mg kg–1bodyweight) of the experimental wounds. We used comparable to that of lotion of thestandard drug and standard solution used for comparison in this present investigation. The results were also comparable of wound contracting ability, epithelization period, regeneration of tissues at the wound area. On Day 14-16th lotion of “Sendeng-4” treated animals exhibited 100% reductionin the wound area when compared to controls. The increased rate of woundcontraction, skin breaking strength and of “Sendeng-4” in wound healing. Conclution:The lotion of traditional herbal formulation of “Sendeng-4” have facilitateswound healing in the experimental animal model.

Objectives: To study of the effects on traditional drug Sendeng 4 for papain-induced osteoarthritis in rats. Methods: The rats were divided into three equal groups in number and were sacrificed under high-dose ether anesthesia after one, two, and four weeks of the last papain injection, respectively. Osteoarthritis was experimented in Wistar rats. Total 21 rats were injecting an admixture of 4% papain and its activator 0.03 M cycteine into the right knee joints on the first, fourth, and seventh days. The same volume of sterile saline solution was injected into the left knees as controls. Result. Pre sacrifice, measured with the artritis scoring evalution and X ray analysis, after cartilage from femorel condyles and tibial plateaus was macroscopically and histophatologically evaluated. The artritis scoring evalution were significantly lower at Sendeng 4 groups (2.2±0.16) compared to the control (3.7±0.25) groups. (p