1.Observation of the effects of 5-aminolevulinic acid photodynamic therapy combined with fulguration in treating perianal condyloma
Huahong WU ; Songbo CHEN ; Jinnan CAI
Chinese Journal of Primary Medicine and Pharmacy 2014;21(11):1612-1614
Objective To evaluate the relapse rate and the effect of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) combined with fulguration in the treatment of perianal genital warts.Methods 67 patients with perianal genital warts were randomly divided into the three groups.22 cases in the fulguration and ALA-PDT treatment group performed the ALA-PDT treatment immediately after removal of dominant wart by fulguration,once a week,treatment for 3-4 times.22 cases in the ALA-PDT treatment group only underwent ALA-PDT treatment,once a week,treatment for one month.23 cases in the fulguration group were given the traditional fulguration methods one by one electrocautery fulguration gasification treatment for all skin lesions,a weekly batch treatment,treatment for a month.Follow-up six months after the last treatment to determine efficacy and recurrence rate.Results The cure rate of combined treatment group was 90.9% (20/22),and recurrence rate was 9.1% (2/22) ;cure rate of photodynamic group was 54.5% (12/22),and its recurrence rate was 22.7% (5/22) ; cure rate of fulguration group was 39.1% (9/23),and the recurrence rate was 43.5% (10/23).There were statistically significant differences in the cure rate and relapse rate between combination therapy group and electrocautery treatment group (P =0.000,P =0.017).Conclusion The fulguration combined with ALA-PDT in the treatment of perianal genital warts has high cure rate,low recurrence rate,and less side effects.
2.Effect of Kangxianyixin prescription on cardiocyte apoptosis and expression of Bax and Bcl-2 in rRats with dilated cardiomyopathy
Zhentao WANG ; Lihua HAN ; Mingjun ZHU ; Chenghao CAO ; Songbo CAI
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(02):-
Objective:To expound the effect of Kangxianyixin prescription on cardiocyte apoptosis and expression of Bax and Bcl-2 in rats with dilated cardiomyopathy. Methods:Wistar rats with dilated cardiomyopathy established by furazolidone were treated 8 weeks with Kangxianyixin prescription,to observe cardiocyte apoptosis and to measure Bax and Bcl-2 expression in rats. Results:(1) In comparison of cardiomyocyte apoptosis indexes in rats,when compared with model group,the results showed significant difference in the combined group of high dosage of Kangxianyixin prescription and captopril,the high dosage group,the low dosage group,the captopril group(P