Postprandial hyperglycemia is one of the characteristics of glucose profiles in Chinese T2DM patients. High-ratio premix insulin analogues with advantages of excellent pharmacokinetic characteristics and flexible and convenient administration provide a comprehensive solution for Chinese T2DM patients to effectively control postprandial glucose and reduce blood glucose fluctuation. This paper is a literature review on its clinical evidence and experience.

Chinese genuine regional herbs are a combination of nature resource and traditional knowledge. Although we can make it to be an intellectual property product through applying geographical indication or certification mark, the value realization of Chinese genuine regional herbs should be supported by the merchant capital. Meanwhile, the merchant capital also disturbs the reasonable market price of Chinese genuine regional herbs. We should combine the merchant capital with Chinese genuine regional herbs, apply permission for sale and set up a new professional cooperation mode to maintain the market credibility and reasonable price of Chinese genuine regional herbs.

Atopic dermatitis is a common chronic recurrent atopic constitution-associated inflammatory skin disease mainly characterized by eczematous lesions and itching. Its etiology and pathogenesis are still not very clear, and there are many controversies about its origin, definition, clinical phenotypes and diagnostic criteria. This review analyzes and discusses these controversies in order to provide a meaningful reference for the diagnosis and treatment of atopic dermatitis.

Objective:To analyze the clinical value on fetal heart monitor combined with umbilical artery S/D monitoring and forecasting fetal distress.Methods: A total of 280 cases in our hospital hospitalized were given maternal heart monitor combined with umbilical artery S/D monitoring. According to the test results, they were divided into normal group with 158 cases, abnormal fetal heart rate group with 21 cases, abnormal S/D value group with 33 cases, both abnormal group with 68 cases. The relationship among fetal heart rate, umbilical artery S/D value and fetal distress were observed.Results: The rate of little amniotic fluid(66.2%), umbilical cord around the neck(35.3%), amniotic contaminated 79.4%), Apgar score<7(50.0 %) and the probability of fetal distress(44.1%) in the fourth group were higher than the other three groups. The differences were statistically significant(x2=8.15,x2=13.54,x2=66.34,x2=11.90,x2=8.37;P<0.05).Conclusion: Fetal heart monitor combined with umbilical artery S/D monitoring and forecasting fetal distress has better efficiency, which can reduce maternal psychological and financial burden.

BACKGROUND:Studieshavesuggestedthat oncogene expression in liver cancer stem cels has a certain relationship withtheoccurrence and development of liver cancer, but there is stil a lack of research on bioinformatics and mechanisms.
OBJECTIVE:To identify differentialy expressed genes in liver cancer stem cels and to analyze these genes by bioinformatics.
METHODS:The human hepatoma cel line HepG2 was the cel tool of liver cancer stem cels to prepare total RNA, andfluorescent labelingexperiment was conducted.Usinggene chipshybridization, mRNA expression profiles were obtained and were screened, and then differentialy expressed mRNAs were obtained,GO and Pathway annotationswere analyzedusing bioinformatics.
RESULTS AND CONCLUSION:The detection rate was 73.21% for hybridization experiment, indicating the hybridization experiment is successful. In this study, a total of 38342 mRNA werefound, and after further analysis, 1236 differentialy expressed genes werescreened (P< 0.05, fold change≥2), including599up-regulated and637down-regulated genes, respectively (P< 0.05). Biological functions of differentialy expressed geneswere mainly involved inthe histone H4 acetylation, cel mitosis and proliferation, synthesis and decomposition of cel-associated proteins, chromosome segregation, cel differentiation and apoptosis, signaltransduction, as wel as nutrienttransportation and transcription. Pathway annotationsweremainly related to cytokine-mediated inflammatory signaling pathway, Wnt signaling pathway, Hedgehog and Notch signaling pathways, TGF-Beta, Jak-STAT and so on. These results demonstrate that differentialy expressed genes in liver cancer stem celsarerelatedto the occurrence of liver cancer, and may be involved in the regulation of signaling pathways, which provides a new target for the treatment of liver cancer.

Objective To study the relation of disease classification and osteoporosis in patients with chronic obstructive pulmonary disease,and to provide a theoretical basis for secondary osteoporosis.Methods A retrospective analysis of clinical data of 126 patients with COPD from January 2012 to December 2014 was made.50 non-COPD patients were included as control group,the pulmonary function and BMD of the femoral neck,trochanter,Ward Dis-trict were detected.And according to FEV1 , all patients were divided into mild pulmonary dysfunction group ( n=31),moderate pulmonary dysfunction group (n=54) and severe pulmonary dysfunction group (n=41);the rate of osteoporosis were measured in COPD group and non-COPD group,the difference of BMD were compared in patients with different pulmonary injury.Results ( 1 ) There were 45 cases of osteoporosis in 126 patients with COPD, accounting for 35.7%, 22 cases of osteopenia, accounting for 17.5%.There were 9 cases of osteoporosis in 50 patients with non-COPD,accounting for 18%,the incidence of osteoporosis were statistically different in COPD group and non-COPD group,χ2 =5.281,P<0.05.(2)The BMD of the femoral neck in mild COPD group,moderate COPD group,severe COPD group and non-COPD group were (0.74 ±0.11) g/cm,(0.66 ±0.08) g/cm,(0.56 ± 0.05)g/cm and (0.94 ±0.10) g/cm,the BMD of trochanter were respectively (0.71 ±0.12) g/cm,(0.63 ± 0.07)g/cm,(0.56 ±0.05)g/cm and (0.95 ±0.08)g/cm,the BMD of Ward District were (0.88 ±0.14)g/cm, (0.72 ±0.10)g/cm,(0.61 ±0.07)g/cm and (0.96 ±0.09)g/cm respectively,which were statistically significant (F=7.557,6.852,7.432,all P<0.01).The BMD of the femoral neck,trochanter,Ward District in COPD group were significantly less than non-COPD,and the more severe of pulmonary dysfunction,the more decreases of bone density.(3) The FEV1% in osteoporosis group,osteopenia group,normal BMD group were respectively (59.0 ±8.7)%,(77.7 ±7.6)% and (49.4 ±15.8)%;the FVC% were (77.8 ±28.8)%,(88.9 ±38.4)%,(73.8 ± 21.1)%;the FEV1/FVC were (66.5 ±20.6)%,(59.8 ±24.2)%,(34.1 ±3.6)%(F=9.554,5.556,7.487,all P<0.01),Conclusion There were a certain correlation between BMD and lung function.Osteoporosis is one of the extrapulmonary effects in elder COPD patients.So BMD should be regularly monitored for helping for early prevention and treatment of osteoporosis and development in osteoporosis,and improving lung function and clinical efficacy.

Objective To investigate application value of dual energy CT nonlinear fusion technology in diagnosis of liver diseases.Methods 86 patients with liver disease screening from 2013 January to 2014 December in our hospital were selected as the research objects.All patients underwent dual energy CT nonlinear fusion and linear fusion imaging,image quality was compared between the two groups of image results,and compared the hepatic lesion area and normal hepatic tissue,change analysis of portal vein of hepatic lesions.Results Nonlinear fusion image CT value difference of (59.71 ±7.64)Hu higher than the value difference linear fusion images of CT (31.35 ± 10.53)Hu,the difference was statistically significant(t =4.361,P <0.05);nonlinear fusion image contrast to noise ratio of liver lesion,hepatic signal -to -noise ratio was (2.94 ±1.06),(5.62 ±1.53),which was higher than that of linear image fusion(4.84 ±2.36),(8.35 ±1.09),the differences were statistically significant(t =1.914,2.059, all P <0.05).Conclusion The use of dual energy CT nonlinear fusion technology can significantly improve the ima-ging quality of CT for liver parenchyma and portal vein without increasing the scanning phase conditions,and nonlinear fusion image for lesions of imaging is linear fusion image clearer,especially small lesions,help to improve the clinical liver lesion detection rate,clinical value.

Deep vein thrombosis is one of venous thromboembolism clinical manifestations,but also a serious,potentially dangerous disease.Thrombosis can occur in various parts of the body veins,and deep venous thrombosis is the most common.Even though most patients with DVT have no clinical symptoms or with mild symptoms,but failure to timely appropriate treatment is easy to progress to post thrombotic syndrome,shares bruises,stock white swollen,which can occur in severe pulmonary embolism and cause death.Although clinically in a variety of measures to prevent DVT formation,including physical prevention and drug prevention,but the incidence of deep vein thrombosis remains high,9-36％ after total hip arthroplasty,and 52％ after total knee arthroplasty.DVT is a disease combined with genetic and non-genetic factors,60％ DVT patients have hereditary risk factors.Currently genetic factors on the formation of DVT study find that clotting factor Ⅺ gene polymorphisms is associated with DVT.Coagulation factor Ⅺ (F Ⅺ) is a serine protease synthesized by the liver and plays an important role in the coagulation cascade process such as maintain the amplification process and the intrinsic pathway.Research on correlation between single nucleotide polymorphisms (SNPs) of F Ⅺ locus rs2289252 and rs2036914 and deep vein thrombosis has become popular.This paper reviews the discovery of coagulation F Ⅺ single nucleotide polymorphism associated with DVT,the degree of association between coagulation F Ⅺ single nucleotide polymorphism and the formation of DVT,risk allele on the clotting F Ⅺ single nucleotide polymorphism,clinical trials of coagulation F Ⅺ and the formation of DVT,coagulation F Ⅺ single nucleotide polymorphisms interact with other genetic polymorphisms,etc.Although the single nucleotide polymorphism in DVT formation mechanism is still vague,we believe that further study of single nucleotide polymorphisms associated with DVT will provide new approaches to prevention and treatment of DVT.

Objective:To compare the clinical efficacies between thin-cotton moxibustion plus surround needling and Western medication in treating herpes zoster (HZ).
Methods:Eighty-three HZ patients were divided into two groups according to their admission sequence, 41 cases in the thin-cotton moxibustion group and 42 cases in the Western medication group. The thin-cotton moxibustion group received thin-cotton moxibustion on the surface of lesions plus surround needling around the lesions, once a day. The Western medication group was intervened by Acyclovir intravenous injection, 0.25 g per dose, once a day, along with external application of Acyclovir cream 3-5 times a day. After 10-day treatment, the blister-healing time, crusting time, pain-reducing time, onset time of action, lesion-healed time, and occurrence of post-herpetic neuralgia (PHN) were compared.
Results:During the study, a case dropped out in the thin-cotton moxibustion group, and 2 cases dropped out in the Western medication group. The recovery and markedly-effective rate was 92.5% and total effective rate was 97.5% in the thin-cotton moxibustion group, versus 72.5% and 87.5% in the Western medication group, and the between-group differences were statistically significant (P<0.05). The blister-healing time, crusting time, pain-reducing time, onset time of action and lesion-healed time in the thin-cotton moxibustion group were significantly shorter than those in the Western medication group (P<0.05). The occurrence rate of PHN was 2.07% in the thin-cotton moxibustion group, significantly lower than 9.19% in the Western medication group (P<0.01).
Conclusion:Thin-cotton moxibustion plus surround needling can produce a more significant efficacy than Acyclovir in treating HZ, and it can markedly reduce the occurrence of PHN.

Objective To explore the effect of early tracheotomy combined with hyperventilation in the treatment of hypertensive cerebral hemorrhage.Methods Clinical data of 76 patients with hypertensive cerebral hemorrhage after operation were retrospectively analyzed,and they were divided into treatment group and control group depending on whether received early tracheal incision joint hyperventilation.3 months after the treatment,the prognosis of the two groups was evaluated and compared according to the Glasgow Coma Score (GCS).Results In the treatment group,there were good in 10 cases,mild disability in 10 cases,severe disability in 9 cases,vegetative state in 3 cases,deaths in 4 cases.In the control group,there were good in 7 cases,mild disability in 7 cases,severe disability in 11 cases,vegetative state patients in 5 cases,deaths in 10 cases,and the efficacy of the treatment group was significantly better than that of the control group (x2 =6.290,P =0.043).In the treatment group,there were 5 cases of electrolyte imbalance,6 cases of kidney dysfunction,8 cases of stress ulcer,8 cases of lung infection.In the control group,there were 11 cases of electrolyte disturbances,10 cases of renal dysfunction,11 cases of stress ulcer,15 cases of lung infection.The incidence rate of complications of the treatment group was significantly lower than the control group (x2 =831.6,P =0.020).Conclusion For hypertensive cerebral hemorrhage,early tracheotomy combined with hyperventilation treatment can improve the patients' survival rate and life quality.