OBJECTIVE:To provide suggestions for the setting-up of the current pharmacovigilance(PV)system.METHODS:The characteristics of the setup of the PV system in both US and France were analyzed and the problems encountered in current monitoring system of adverse drug effects were pointed out.RESULTS & CONCLUSION:Both American and French PV systems have their own advantages and we should learn from it and draw useful experiences from them.In constructing PV system,China should make improvement in organization,communication,financial resource and information technology etc.

In order to have a better understanding of the relation between vertical dimension and occlusal force,a meter was made by means of straingauge.Five Japanese men were investi- gated for occlusal force at different vertical dimensions.The measurements showed that the maximal occlusal force of the posterior teeth occured at 8 to 15mm or the vertical dimension, the maximal occlusal forec of the anterior teeth occured at 13 to 18mm.This indicated that the occlusal force was closely related to the state of jaw closing muscle.

Animals ; Blood Glucose ; Cucurbita ; chemistry ; Diabetes Mellitus, Experimental ; drug therapy ; Hypoglycemic Agents ; pharmacology ; Lipids ; blood ; Oxidative Stress ; Polysaccharides ; pharmacology ; Rats

Intrinsic or acquired chemo-resistance is the main reason for chemotherapy failure, and thus finding ways to reverse chemo-resistance has become an interesting topic for research. Studies have revealed that immunomodulatory molecules are involved in cancer chemo-resistance. Hence, interventions that target immunomodulatory molecules to reverse chemo-resistance have attracted a great deal of concern from domestic and foreign scholars. Immunomodulatory molecules, such as PD-L1, B7-H3, HMGB1, TRAIL, MyD88, and Cytokines (TNF-α, IFN-α, IL-6), have been proven to take part in regulating immune function and tumor drug-resistance characteristics, thereby providing new ideas to the reversal of tumor chemo-resistance. This artide reviews the progression of immuno-modulatory molecules with the change in cancer chemotherapy sensitivity to provide a theoretical basis for the application of new thera-peutic regimen of bio-chemotherapy.

Objective To investigate the chemical constituents in the leaves of Dracaena cochinchinensis.Methods The compounds were separated with column chromatography and their chemical structures were identified by physicochemical and spectral method,respectively.Results Thirteen compounds were isolated from the plant. They were identified as isorhamnerin(Ⅰ),quercetin(Ⅱ),25(R)-spirostane-5-en-3?-ol(Ⅲ),gracillin(Ⅳ),25(R)-spirostane-5-en-3?,14?-diol(Ⅴ),25(R)-spirostane-5-en-3?,14?-diol-3-O-?-D-glucopyranoside(Ⅵ),25(R)-spirostane-5-en-3?,14?-diol-3-O-?-L-rhamnopyranosy(1→4)-?-D-glucopyranoside(Ⅶ),25(R)-spirostane-14?-hydroxy-4-en-3-one(Ⅷ),7?-hydroxysistosterol-3-O-?-D-glucopyranoside(Ⅸ),?-stigmasterol(Ⅹ),stigmasterol-3-O-?-D-glucopyranoside(Ⅺ),daucosterol (Ⅹ Ⅱ),and methyl ?D-glucopyranoside(Ⅹ Ⅲ).Conclusion Spirostane-type steroids are the major constituents in the leaves of D.cochinchinensis.Compounds Ⅰ-Ⅲ,Ⅴ,Ⅵ,Ⅷ,and Ⅸ are isolated from this plant for the first time.

Superselective angiography and embolization is one of the important methods in the management of acute hemorrhage, providing mini-invasion and high efficacy, etc. The implication of angiography and embolization on bleeding were reviewed and the embolic agents as well as the interventional procedures were commented in this article.

Objective To study the chemical constituents in the roots of Flemingia macrophylla Methods To separate and purify compounds by column chromatography and TLC, and to determine their chemical structures by their physical characters and spectral data. Results Eleven compounds were purified from the extraction in the roots of F. macrophylla, among them four are isoflavones, three are flavanones, and one is flavanol. They are genistein (Ⅰ), orobol (Ⅱ), 5, 7, 4′-trihydroxyisoflavone-7-O-?-D-glucopyranoside (Ⅲ), 5, 7, 4′-trihydroxy-8, 3′-diprenylflavanone (Ⅳ), 5, 7, 4′-trihydroxy-6-prenylisoflavone (Ⅴ), flemichin D (Ⅵ), lespedezaflavanone A(Ⅶ), ouratea-catechin (Ⅷ), 3, 4, 5-trimethoxybenzene-O-?-D-glucopyranoside (Ⅸ), stigmasterol-3-O-?-D-glucopyranoside (Ⅹ), and stigmasterol (Ⅺ). Conclusion Compounds Ⅲ—Ⅴ, and Ⅶ—Ⅺ are found from this plant for the first time. All the compounds are found from the roots of this plant for the first time. The active components, genistein and its isoflavone analogs, are main constituents in the roots of F. macrophylla

Objective: To establish a method for quality control of chitosan hemostatic Sponge. Methods: To study the indentification of chitosan , Lidocaine Hydrochloride ,Norfloxacin and inspect the suction water of sponge. Extracting Lidocaine Hydrochloride and Norfloxacin with acid and alkali then determining the content of them by spectrophotometic method. Results: The indetification experiment showed a good result . The suction water of sponge outstripped more than 20 times. The average content of Lidocaine Hydrochloride was 9.55mg/g ,Norfloxacin was 8.46mg/g. The average recovery of Lidocaine Hydrochloride and Norfloxacin was 97.9% and 96.5%. Conclusion: This method can be used to establish the quality control of chitosan hemostatic sponge.

Objective To investigate the effects of the EGF on isolation and cloning of mouse embryonic stem-like cells from PGCs. Methods EGF with different density were added to the culture medium of cells .After a culturing period ,the cloning number of mouse embryonic stem-like cells and the topmost passage would be observed and registered. Results There was not obvious effects on the primary culture of mouse ESC and was distinct on the later passage if EGF were used. Conclusions In the primary passage of mouse ESC may survive without EGF,and the impact of the existence of EGF was better than the one of the inexistence to the cloning of mouse ESC.

Observations of the ultrastructural changes in neurons of hypothalamie arcuate, supraoptic and paraventricular nuclei were carried out in the rats following gossypol treatment at a dosage of 30mg/kg/day for 5 weeks. The results showed that after gossypol treatment no marked changes in supraoptic and paraventricular cells could be seen at electron microscopic level, and that there appeared a series of ultrastrucrural changes reflecting increased neurosecretory activity in some of arcuate neurons.They were as follows: Golgi complex and rough endoplasmic reticulum were slightlydilated and filled with homogeneous, low electron density materials in their cisternae; the amounts of neurosecretory granules, lysosomes, nucleolus-like bodies, and microtubules were increased. The nature, significance and cause of these changes are discussed.