1.Chronic non-healing ulcers as presenting sign of acquired immunodefciency syndrome
Nikoo Mozafari ; Soheila Nasiri ; Tara Barat ; Farahnaz Bidari- Zerehpoosh
Malaysian Family Physician 2020;15(2):30-33
A typical forms of herpes simplex virus (HSV) infections, which indicate severe impairment of cellular
immunity can be challenging to diagnose. In this paper, we report the case of an atypical HSV
infection presenting as chronic nonhealing wounds, which are the frst sign of HIV, in a 50-year-old
female patient. Te lesions had emerged as two large, chronic, and painful ulcerations on the left
buttock and labia major 8 months prior. Te skin biopsy revealed multinucleated keratinocytes with
ground glass nuclei and intranuclear Cowdry type A viral inclusions. A serologic test for HIV-1 was
positive. Her CD4+T-cell count was 42/mm3. Clinicians should be familiar with the dermatologic
manifestations of HIV, as they are occasionally key to correctly suspecting an underlying HIV
infection, allowing for early diagnosis and treatment.
2. Elevated serum nitric oxide and hydrogen peroxide levels as potential valuable predictors of herpes zoster
Soheila NASIRI ; Reza ROBATI ; Marjan KHAZAN ; Mehdi HEDAYATI ; Seyed RIAHI ; Seyed RIAHI
Asian Pacific Journal of Tropical Medicine 2018;11(6):381-386
Objective: To evaluate the biomarkers of oxidative stress in herpes zoster patients compared with control subjects. Methods: This study compared the nitric oxide (NO), hydrogen peroxide (H