1.Unilateral Axillary Arch and Variations in the Axillary Vein and Intercostal Nerves: A Case Report
Sharada Ramanadham ; Sneha Guruprasad Kalthur ; Shakunthala R Pai
Malaysian Journal of Medical Sciences 2011;18(1):68-71
Knowledge of muscular, vascular, and neural variations in the axilla is of great clinical
importance, especially in mastectomies, breast reconstruction, and axillary bypass operations. In
the present paper, we report unilateral variations observed in the axillary region of a male cadaver. A
fibromuscular axillary arch was observed on the right side. On the same side, there was a bifurcated
axillary vein; a medial cutaneous nerve of the arm passed through and later ran beneath this axillary
vein. In addition, the intercostobrachial nerve was absent on the right side. The clinical significance
of the variations observed and their embryological basis are discussed in this paper.
2.Development of the Fetal Ureter: A Fetal Metric and Histological Study
Priya. J. MARTIS ; Anne D SOUZA ; Vidya MONAPPA ; Nandini Prashanth BHAT ; Sneha Guruprasad KALTHUR
Malaysian Journal of Medicine and Health Sciences 2018;14(1):15-20
Introduction: This study provides a description of development of various components of the human ureter at different gestational ages. Methods:Measurements of the length of the ureter from pelvi-ureteric junction to vesico-ureteric junction, length of its intravesicular portion and angle made by the ureter at the entry into the bladder with respect to the internal ureteric orifice were taken. Transverse sections of the ureter were taken at the upper end, close to the pelvi-ureteric junction, and at the midpoint between the pelvis of the kidney and the vesico-ureteric junction. These were subjected for processing and stained with Haematoxylin Eosin and Masson’s Trichrome. They were then studied under the light microscope. Results: The length of the ureter from the pelvi-ureteric junction to the vesico-ureteric junction showed a highly positive correlation with the gestational age (GA). The angle of entry of the ureter to the bladder decreased as the GA increased. The microstructure of the ureter in both the sections showed development of transitional epithelium with an increase in layers by 33 weeks. At 18 weeks, the smooth muscle layer was in a single layer with an abundance of interspersed collagen fibers. By 33 weeks, the thickness of the wall increased significantly with a decrease in collagen. There was no trace of longitudinal muscle fibers even upto 33 weeks. Conclusion: Epithelial, muscular and connective tissue components displayed significant changes during intra uterine development.
3.Anthropometric and Histologic Study of Liver and Kidney of Foetuses and Their Correlation With Gestational Age
Aina Aggarwal ; Chandni Gupta ; Vikram Palimar ; Sneha Guruprasad Kalthur
Malaysian Journal of Medicine and Health Sciences 2020;16(No.4):96-100
Introduction: It is very important to accurately estimate the age of foetus for various medicolegal cases. This study
is an attempt to establish a relationship between anthropometric measurements and histologic analysis of liver and
kidney to identify gestational age of the foetus. Methods: The study was carried on 30 fetuses. Their anthropometric
measurements were done using Vernier calipers. The data was statistically analyzed by computation to find out its
normative value. Histologic analysis was done by preparing hematoxylin and eosin stained slides and looking under
light microscope. The relationship between gestational age and data thus obtained was determined. Results: Size of
liver and kidneys increased with every trimester. The kidney showed immature duct system and clustered glomeruli
with lack of differentiation into cortex and medulla in first trimester. Tubular differentiation started in second trimester which finished in third trimester with formation of juxtaglomerular apparatus. Size of glomerulus was, however,
maximum during second trimester, followed by first and third trimester. In liver, haemopoeisis was observed in first
trimester which decreased with subsequent trimesters. Lobular differentiation increased with each trimester. However, full term liver did not have the classic lobular pattern. Size of sinusoids decreased with every trimester. Abundant
fibrous tissue was observed around portal triad. Conclusion: There is a relationship between the gestational age and
anthropometric measurements and histologic features of liver and kidney of the foetus. This will help in identifying
foetal age as well as any congenital kidney and liver diseases.