Five patients with Peutz-Jeghers Syndrome(PJS) have been reported in this paper. One ofthem developed polypous malignancy in the rec-tum, one associated with bladder canaer. The au-thers have once performed multiple operations, in-cluded small bower Roux-Y anastomosis keepedpylorus for a patiet with duodenal obstruction in-duced by polyps. The questions related with surgi-cal management is PJS are discussed principally inthis paper.