1.Identification of Y Chromosomal Material in Turner Syndrome by Fluorescence In Situ Hybridisation (FISH)
Reena Rahayu Md Zin ; Sharifah Noor Akmal ; Zubaidah Zakaria ; Clarence Ko Ching Huat ; Siti Mariam Yusof ; Julia Mohd Idris ; Zarina Abdul Latif ; Wu Loo Ling ; Wong Ming
Medicine and Health 2008;3(1):22-29
Turner syndrome is one of the most common chromosomal abnormalities affecting
newborn females. More than half of patients with Turner syndrome have a 45X karyotype.
The rest of the patients may have structurally abnormal sex chromosomes or are mosaics
with normal or abnormal sex chromosomes. Mosaicism with a second X sex chromosome
is not usually of clinical significance. However, Turner syndrome patients having a second
Y chromosome or Y chromosomal material are at risk of developing gonadoblastoma later in life. The aim of this study is to compare the results of conventional (karyotyping) and
molecular cytogenetics (FISH), and discuss the advantages and limitations in the
diagnosis of Turner syndrome. We also aim to compare the degree of mosaicism identified
using conventional cytogenetics and FISH techniques. Conventional cytogenetics and
FISH analyses were performed on eight peripheral blood samples of patients with Turner
syndrome collected between 2004 and 2006. From this study, two out of eight patients with
Turner syndrome were found to have the sex determining region on the Y chromosome
(SRY) gene by FISH analysis. Our results showed that the rate of detection of mosaic
cases in Turner syndrome was also increased to 88% after using the FISH technique. We
concluded that FISH is more superior to conventional cytogenetics in the detection of the Y
chromosomal material. FISH is also a quick and cost effective method in diagnosing
Turner syndrome and assessing the degree of mosaicism.
2.Management of Atopic Eczema in primary care
Ainol Haniza Kherul Anuwar ; Azura Mohd Affandi ; Ch&rsquo ; ng Chin Chwen ; Dawn Ambrose ; Heah Sheau Szu ; Khor Yek Huan ; Lalitha Pillay a/p B. Gopinathan ; Leow Wooi Leong ; Mohd. Aminuddin Mohd. Yusof ; Noor Zalmy Azizan ; Sabeera Begum ; Siti Shafatun Mohsin ; Tan Wooi Chiang ; Tarita Taib ; Wong Ping Foo ; Zaridah Zainuri ; Siti Mariam Tukimin
Malaysian Family Physician 2020;15(1):39-43
Introduction: Atopic eczema (AE) is a common infammatory skin dermatosis that is increasing
in prevalence. However, it can present in various clinical presentations, which leads to challenges
in the diagnosis and treatment of the condition, especially in a primary care setting. Te Clinical
Practice Guidelines on the Management of Atopic Eczema was developed by a multidisciplinary
development group and approved by the Ministry of Health Malaysia in 2018. It covers the aspects
of diagnosis, severity assessment, treatment, and referral.