1.The Protective Effects of Tetrahydropalmatine against Hippocamp Lesion Induced by Ischemia-Reperfusion in Rats
Qing MIN ; Jiliang WU ; Chao LIU ; Sijie SU
Herald of Medicine 2001;(5):284-285
Objective: To study the protective effects of tetrahydropalmatine (THP) against ischemia-reperfusion induced hippocamp lesion in rats. MethodS: A model of ischemia-reperfusion induced brain lesion was set up by ligation of common carotid arteria in rats, and the protective effects of THP was observed. Results: It was found that, with administration of THP, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and Na+, K+-ATPase as well as Ca2+-ATPase were increased (P<0.05, respectively), while malondialehyde (MDA) was decreased to 42.5% (P<0.01) during brain ischemia-reperfusion. Conclusion:The results suggested that THP can protect the rat against ischemia-reperfusion induced brain lesion.
2. The impact of male circumcision on the natural history of genital HPV infection: a prospective cohort study
Feixue WEI ; Meng GUO ; Xinjing MA ; Yue HUANG ; Ya ZHENG ; Lin WANG ; Yan SUN ; Sijie ZHUANG ; Kai YIN ; Yingying SU ; Shoujie HUANG ; Mingqiang LI ; Ting WU ; Jun ZHANG
Chinese Journal of Preventive Medicine 2018;52(5):486-492
Objective:
To analyze the correlation between circumcision and incidence and clearance of male genital HPV infection.
Methods:
From May to July 2014, 18-55 year old men who had sexual behavior history were recruited from the general population in Liuzhou, Guangxi to set up a cohort. Totally, 113 circumcised and 560 uncircumcised men were enrolled and interviewed using a questionnaire (including information on demographic characteristics and sexual behaviors), then they were followed-up with 6-month interval for 2 times. On each visit, specimens of male external genitalia were collected and genotyped for HPV DNA. The differences of incidence and clearance of genital HPV infections between circumcised and uncircumcised men were analyzed by Log-rank test. Cox regression was used to analyze the relationship between circumcision and incidence and clearance of HPV infection.
Results:
The median age (