OBJECTIVE: Percutaneous aspiration sclerotherapy is indicated for treatment of symptomatic renalcysts. The efficacy and safety of the different sclerosing agents have been sources of debate anddisagreement. The purpose of this study was to assess the efficacy and safety of using tetracyclineaspiration sclerotherapy in a systematic review of the literature. MATERIALS AND METHODS: A systematic search was conducted on the following electronic databases:Cochrane Central Register of Controlled Trials, EMBASE, PubMed and HERDIN (until November2017). Studies of cyst volume reduction after tetracycline aspiration sclerotherapy were included forfull text evaluation. The quality of the studies and the risk of bias were assessed independently by theauthors, based on the Cochrane Handbook for Systematic Reviews of Interventions. RESULTS: Three studies were included for full-text assessment. They included 87 patients. Overall, riskof bias was high. Complete renal cyst disappearance ranged between 29%-100% after a follow-upperiod of 3-36 months. Partial success/>50% renal cyst reduction ranged between 85.7%-100%.Complications were minor and self-limited, postoperative procedural pain occurred most frequently. CONCLUSION The authors found good results with respect to efficacy and safety after tetracyclineaspiration sclerotherapy of renal cysts. However, due to high risk of bias in the included studies,definite conclusions regarding efficacy could not be drawn.

BACKGROUND: Prostate cancer is the most common malignant tumor among adult men worldwide andthe second most common cause of cancer death. Gleason grading system is a powerful predictor in theprognosis and treatment outcome of prostate carcinoma. OBJECTIVE: This retrospective study aims to evaluate the accuracy of transrectal ultrasound (TRUS)-guided biopsy of the prostate compared to radical prostatectomy specimen in predicting thepathological grading of prostate adenocarcinoma using the Gleason scores between specimens. METHODS: This is a review of 69 patients who underwent radical prostatectomy due to prostate cancerin 2010-2015. The Gleason scores of the transrectal ultrasound biopsies were compared with thesurgical specimen. RESULTS: The biopsy Gleason scores obtained from the TRUS biopsy and the radical prostatectomyspecimens were similar in 79.7% of the cases. In patients with moderately differentiated tumors onbiopsy (Gleason score of 5 to 7), the concordance rate was 83% with upgrading after surgery in 16%of the cases. In poorly-differentiated tumors on biopsy (Gleason score of 8 to 10), 74% revealed thesame score on histopathological examination after radical prostatectomy, while 25% of the caseswere given lower Gleason scores after operation. Overall, 20.3% cases were discrepant by 1 or moreGleason scores after radical prostatectomy. There was a good histopathological correlation betweenTRUS biopsy and prostatectomy specimen {AUC =0.787(p=0.001)}. CONCLUSION The overall accuracy of Gleason score on transrectal ultrasound-guided biopsies inpredicting prostatectomy specimen grade is favorable. It plays a significant role in clinical decisionmaking of patients with prostate carcinoma.