BACKGROUND: The external jugular vein (EJV) is a useful intravenous (IV) cannulation site for anesthesiologists, although it has a relatively high failure rate. Unlike other central veins, visualization of the EJV is important during IV cannulation, and the Valsalva maneuver distends the jugular venous system. However, the relationship between the maneuver and EJV visibility remains unknown. This study compared EJV visibility before and after the Valsalva maneuver. METHODS: This was a prospective observational study that included 200 participants. After the induction of anesthesia, EJV visibility grade, depth from the skin to the EJV superficial surface (EJV depth), and EJV cross-sectional area (CSA) before the Valsalva maneuver were measured. The same parameters were measured after the Valsalva maneuver was performed. The EJV visibility grade was defined as grade A: good appearance and good palpation, grade B: poor appearance and good palpation, and grade C: poor appearance and poor palpation. RESULTS: Patient body mass index and EJV depth affected the EJV visibility grade before the Valsalva maneuver (p < 0.05), although EJV CSA did not. The Valsalva maneuver distended EJV CSA and reduced EJV depth, although these changes were not correlated with EJV visibility grade. With regard to EJV visibility, 34.0% of grade B cases and 20.0% of grade C cases were improved by the Valsalva maneuver. CONCLUSIONS: Although the Valsalva maneuver improved EJV CSA and EJV depth, it did not greatly affect EJV visibility grade.
Anesthesia ; Body Mass Index ; Catheterization ; Humans ; Jugular Veins* ; Observational Study ; Palpation ; Prospective Studies ; Skin ; Ultrasonography ; Valsalva Maneuver* ; Veins

OBJECTIVE: This study has been carried out to explore the genetic causes of bipolar disorder by comparing the frequency of Tryptophan Hydroxylase (TPH) A218C polymorphism between bipolar disorder patients and normal controls, and to explore the relation between clinical characteristics of bipolar disorder patients and TPH polymorphism. METHODS: The genotype and allele frequencies of TPH in the genome of 113 hospitalized patients with bipolar disorder was compared with those of 124 normal control subjects using polymerase chain reaction and restriction fragment length polymorphism. The association between TPH A218C polymorphism and clinical characteristics in bipolar disorder patients were explored. RESULTS: The distributions of TPH A218C polymorphism between the patients with bipolar disorder and normal control subjects show no difference statistically. There was a significant difference in the distribution of TPH genotype by clinical characteristics. The frequency of C allele is significantly higher in patients with a history of suicidal attempts. The frequency of A allele is significantly higher in patients with family history of bipolar disorder. CONCLUSION: This study suggests that suicidal attempts and family history in the patients with bipolar disorder are clearly associated with TPH A218C polymorphism and may explain, in part, the biological basis for these typologies.
Alleles ; Bipolar Disorder* ; Gene Frequency ; Genome ; Genotype ; Humans ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Suicide ; Tryptophan Hydroxylase* ; Tryptophan*

Early sexual debut, partner violence, pregnancy and sexually transmitted infections contribute to negative health outcomes among adolescents. While the primary care clinics offer accessible sexual and reproductive health (SRH) services to adolescents, it is uncertain whether adolescents are aware of and utilize these services. This study aimed to examine Malaysian adolescents’ knowledge, utilization and barriers to primary care services for SRH. A cross-sectional survey was conducted from August to November 2011 among adolescent from five randomly selected schools in Selangor, Malaysia. A self-administered questionnaire was used to assess their knowledge, attitudes, sexual behaviors and utilization of SRH services. A total of 680 adolescents participated in the study. One in ten of the adolescents were aware of the availability of SRH services, and only 6.9% of them had ever visited a primary care clinic for SRH. About 75% of them felt uncomfortable going to a primary care clinic for SRH services. Knowledge and utilization of primary care clinics for SRH among adolescents in Malaysia is poor.

Although not strictly a highlands province, Morobe encompasses large highlands areas, the most important being Aseki, Menyamya and Wau-Bulolo. A series of rapid malaria surveys conducted in both the wet and dry seasons found malaria to be clearly endemic in areas below 1400 m in Menyamya and Wau-Bulolo, with overall prevalence rates in the wet season (25.5%, range: 9.1%-39.2%) greatly exceeding those in the dry season (8.3%, range: 2.4%-22.8%; p < 0.001). In the wet season surveys Plasmodium falciparum was the clearly predominant species, accounting for 63% of all infections. P. vivax increased in frequency in the dry season (from 27% to 46%, p < 0.001), while P. falciparum and P. malariae decreased. In line with past surveys a low prevalence of malaria was found in the Aseki area. Malaria was found to be the main source of febrile illness in the wet season with at least 60% of measured or reported fever associated with parasitaemia. Other causes of febrile illness dominated in the dry. In villages with parasite prevalence rates < 20% mean haemoglobin levels and prevalence of severe anaemia were strongly correlated with overall parasite prevalence. In addition concurrent malarial infections were associated with a strong reduction of individual haemoglobin levels (-1.2 g/dl) and there was increased risk of moderate-to-severe anaemia with concurrent malaria. Malarial infections are thus the most significant cause of febrile illness and anaemia in the highlands fringe populations in Morobe. As a consequence all villages below 1500-1600 m in Morobe Province should be included in malaria control activities.
Malaria ; Seasons ; Prevalence aspects ; Fever ; upper case pea

Of all Papua New Guinea provinces, Enga has the largest proportion of people living at altitudes that preclude malaria transmission. However, the first systematic surveys in 1979 showed that malaria was endemic in lower-lying valleys to the north and east of the province. A series of new surveys conducted in both wet and dry seasons showed that these areas remain the main malaria focus in Enga. However, over the last 25 years the risk of malarial infections has increased substantially in areas < 1200 m (from 10% to 37-41%). In these low-lying areas people acquire substantial antimalarial immunity and most infections are asymptomatic. However, people in villages in these areas had significantly lower mean haemoglobin levels (13.0 vs 14.0 g/dl, p < 0.001) than in areas above 1200 m, where overall prevalence rates (0-9%) have not changed much. In areas between 1200 and 1600 m epidemics with parasite prevalence rates in excess of 20% have been found to occur. Malaria was a significant cause of febrile illness only in endemic areas or during outbreaks. Although rarely used, sleeping under a bednet was associated with a significant reduction in risk of malaria infection (adjusted OR = 0.45, p = 0.01). On the other hand, sleeping in garden houses away from the main villages increased the risk of malaria infection (adjusted OR = 1.6, p = 0.03). Malaria control in outlying, malarious areas of Enga province could therefore be based on the distribution of long-lasting impregnated bednets, while at the same time addressing the additional risks posed by the high mobility of many of these populations through targeted health education.
Malaria ; meter ; lower case pea ; Risk ; Papua New Guinea

Introduction: A smooth transition of healthcare for young people with chronic illnesses from paediatric to adult healthcare services is important to ensure optimal outcome. At the moment, there are no standard guidelines to assess a patient's readiness to transfer care. Methods: A cross-sectional study using a self-administered questionnaire, adapted from UNC (University of North Carolina) TRxANSITION self-assessment tool was conducted to evaluate patients’ transition care readiness in paediatric haematology and paediatric diabetes clinic. Results: A total of 80 patients (37 thalassaemia and 43 diabetes) with the mean age of 21.2 (SD±4.3) years, were recruited during the 3-month study period. Majority of the patients have basic knowledge regarding their medications, and were able to comply with their follow-up. The mean total score obtained by the respondents on this questionnaire was 15.3 (SD±3.59). Self-management skills and knowledge on disease were the two poorly scored section; with mean score of 3.78 (SD±1.38) and 4.28 (SD±1.20) respectively. Overall, only 21 (26.2%) respondents obtained high score (score above 75th percentile). Seventy-five percent of the respondents admitted that they were not ready for transfer to an adult healthcare service yet at the time of the study. Conclusion: We suggest that patients with high score should be prepared for transition to adult facility whereas those with a low score need to be identified to ensure provision of continuous education.

Purpose: This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses. Methods: The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression. Results: The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience. Conclusion In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.

Purpose: This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses. Methods: The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression. Results: The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience. Conclusion In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.

Purpose: This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses. Methods: The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression. Results: The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience. Conclusion In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.

Purpose: This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses. Methods: The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression. Results: The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience. Conclusion In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.