1.Initiating or switching to insulin degludec/insulin aspart in adults with type 2 diabetes in Malaysia
Mafauzy Mohamed ; Siang Chin Lim ; Malik Mumtaz ; Shweta Uppal ; Deepak Mukherjee ; Mohamed Saiful Mohd Kassim ; Shalini Sreedharan ; Amudha Murugan Doraiswamy ; Kuck Meng Chong ; Lu Yu Tat ; Sudzilla Binti Nordin ; Jeshen Lau Hui Giek ; Zanariah Hussein ; Khalid Abdul Kadir ; Bik Kui Lau ; Siew Pheng Chan
Journal of the ASEAN Federation of Endocrine Societies 2023;38(1):37-44
Objectives:
Insulin degludec (IDeg)/insulin aspart (IAsp; IDegAsp) is a co-formulation of 70% IDeg and 30% IAsp. According to several randomized controlled trials, IDegAsp is effective and safe for patients with type 2 diabetes mellitus (T2DM). A subgroup analysis of the ARISE study was conducted to explore the safety and efficacy of IDegAsp among Malaysian patients with T2DM in real-world settings.
Methodology:
ARISE, an open-label, multicenter, non-interventional, prospective study was conducted between August 2019 and December 2020. Adult Malaysian patients with T2DM who were enrolled from 14 sites received IDegAsp as per the local label for 26 weeks. The primary endpoint was change in glycated hemoglobin (HbA1c) levels from baseline
to end of study (EOS).
Results:
Of the 182 patients included in the full analysis set, 159 (87.4%) completed the study. From baseline to EOS, HbA1c (estimated difference [ED]: –1.3% [95% CI: –1.61 to –0.90]) and fasting plasma glucose levels (ED: –1.8 mmol/L [95% CI: –2.49 to –1.13]) were significantly reduced (p<0.0001). The patient-reported reduced hypoglycemic episodes (overall and nocturnal) during treatment. Overall, 37 adverse events were observed in 23 (12.6%) patients.
Conclusion
Switching or initiating IDegAsp treatment resulted in significant improvements in glycemic control and a reduction in hypoglycemic episodes.
Result Analysis
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