Thirty-eight cases with hysteromyoma were treated with Hai-Kun decoction. The effective rate which hysteromyoma was eliminated and reduced was 52. 78%. The cure effect was better than control groupand there was a significant difference (P

Objective To observe the influence of systemic and intraperitoneal hyperthermic perfusion chemotherapy on serum vascular endothelial growth factor(VEGF) and human epididymis protein 4 (HE4) in patients with ovarian cancer.Methods 116 cases with ovarian cancer were,randomly divided into the observation group and the control group according to the number table,58 cases in each group.The observation group was given systemic and intraperitoneal hyperthermic perfusion chemotherapy,and the control group received systemic chemotherapy,they all completed a total of two cycles of chemotherapy.Serum VEGF and HE4 were measured before and after chemotherapy.Results The total effective rate of the observation group was 74.1％,and that was 56.9％ of the control group,the difference was significant (x2 =4.290,P ＜ 0.05).After chemotherapy,the serum VEGF and HE4 were signifi cantly decreased in two groups,and compared with the control group,the observation group decreased more significantly(t =3.180,2.725,all P ＜ 0.05).Conclusion Systemic and intraperitoneal hyperthermic perfusion chemotherapy in treatment of patients with ovarian cancer can significantly reduce serum VEGF and HE4.

objective To investigate the changes in angiotensin-Ⅱ (AT-Ⅱ), endothelin (ET) andcalcitonin gene-related peptide (CGRP) during clipping of intracranial aneurysm performed under desfiuraneanesthesia. Methods Forty-five ASAⅠ -Ⅱ patients (20 male, 25 female) aged 14-66yr undergoing electiveclipping of intracranial aneurysm two weeks after acute subarachnoid bleeding. Anesthesia was induced withmidazolam 0 .05 mg?kg~(-1), fentanyl 2?g?kg~(-1), propofol 2 mg?kg~(-1) and vecuronium 0.1 mg?kg~(-1). The patientswere mechanically ventilated after tracheal intubation and P_(ET)CO_2 was maintained at 30-35 mm Hg. Anesthesia wasmaintained with desflurane at 1 .0-1 .5 MAC with low flow (0.3-0.5 L?min~(-1) ) supplemented with intermittentintravenous boluses of vecuronium. Radial artery was cannulated for direct continuous BP monitoring. ECG, HR,SPO_2 and P_(ET) CO_2 were continuous monitored during operation. Blood samples were taken before induction ofanesthesia (T_1, baseline), when dura was opened (T_2 ), while aneurysm was being clipped (T_3 ) and 30 min afterclipping for determination of plasma concentrations of AT-Ⅱ, ET and CGRP. Results Plasma concentration ofAT-Ⅱ did not change significandy throughout the surgery. Plasma ET concentration decreased significantly at T_2and T_3 compared with the baseline (P

Objective The differentially expressed genes in the progress of cellular senescence were studied. Methods Suppression subtractive hybridization was used to young and senescent human diploid fibroblast 2BS cells, then screening and analyzing the subtractive libraries. Results Two kinds of subtraction libraries were obtained, respectively representing the differential genes with higher expression in young cells or senescent cells. Screened by dot blot, thirty of genes with differential ratio larger than 2 were sequenced, showing changes in much of cell functions. Some of them also had expression change between blood samples from newborn or old people. Conclusions The differential expression of RBM4?FBXO7?TOM1 is reported during 2BS cell senescence for the first time. There are the similarities during the senescence of culture cell and organism.

Cerebral topographic map (CTM) and electroencephalogram (EEG) can evaluate the functional activity of brain, and the purpose of this study was to objectively compare the effect of intravenous anesthetics on brain. Forty-five patients, ASA grade Ⅰ-Ⅱ, undergoing neurosurgery,were randomly divided into three groups after administration of Innovar 2 ml, and then equivalent effective dose of propofol(2～2.5 mg/kg)(Ⅰ),sodium thiopental (4～6mg/kg)(Ⅰ) or gama hydroxybutyrate sodium (70～80mg/kg)(Ⅲ) was intravenously given respectively. All patients were monitored continuously during induction. The high frequent excitative activities of ? rhythm appeared immediately after each anesthestic was injected. During the most effective period: in group Ⅰ, there were no ? rhythm in EEG and obvious power change on CTM; in group Ⅱ irregular ? rhythm took place in EEG occasionally and great increase in top power on CTM occured, which showed evident elevation compared with group Ⅰ (P

Objective: To observe the effects of total intravenous anesthesia(TIVA)and spontaneous respiration on brain oxygen balance status in patients undergoing brain stem neoplasm resection. Method: Thirty patients,ASA grade Ⅰ-Ⅱ, received endotracheal intubation with spontaneous respiration and TIVA. TIVA was maintained with intravenous 0.2% lidocaine 2-3mg?kg~(-1). h~(-1),0.4% propofol 4-6mg?kg~(-1),h~(-1)and 1% ketamine 1-1.5mg?kg~(-1). h~(-1). Arterial and jugular bulb blood samples were taken before and after induction,sawing skull and removing trmor seperately to analyse blood gas. According to Fick principle, the level of CaO_2,CjvO_2 and C (a-jv)O_2 were calculated. Result:The hymodynamics, SaO_2 and CaO_2 remained stable during whole procedure. In comparison with the baselines. respiratory rate, minute volume, arterial blood pH and C(a-jv)O_2 were decreased, and PaCO_2.SjvO_2, and CjvO_2 were increased significantly (P

Objective To investigate the effect of isoflurane at different concentration on the quantitative electroencephalogram(SEF and BIS) , intracranial pressure(ICP) and hemodynamics during neurosurgery Methods Thirty ASA grade Ⅰ Ⅱ patients with saddle tumor ,scheduled for selective operation, were randomly divided into three groups after induction with fentanyl propofol vecuronium and intubation Anesthesia was maintained with inhalation of 0 5,1 0 or 1 5 MAC of isoflurane in each group respectively MAP,HR,ICP,SEF and BIS were recorded before induction,reaching the designed MAC, at incision ,sawing bones and opening dura Results SEF and BIS decreased significantly with increases in concentration of isoflurane MAP decreased markedly at1 5 MAC compared with that at 0 5 MAC (P

Objective To study the adverse health effects of indoor decoration on the inhabitants and to provide scientific evidences for improving the living conditions.Methods To investigate the condition of room decorating,fitment and the health situation of inhabitants,then analyze the data by multiple Logistic regression.Results The indoor air pollution caused by indoor decoration could cause many kinds of complaints.The result of single factor analysis showed that less than 6 months after the decoration(OR=9.45),to live in the room in less than half month after the decoration(OR=1.97)and living in the room for less than 1 month(OR=16.19)maybe increase the risk of complaints.When adjusted the effects of the other influence factors,the result showed that the longer the time of decoration was finished,the lower the risk of complaints was(OR=0.82,95%CI:0.73-0.91).Keeping ventilation could decrease the risk of complaints(OR=0.68,95%CI:0.54-0.87).Conclusion The results of this investigation indicate that the discomfortable symptoms of inhabitants living in the room decorated recently are the combined results of many factors which include room decorating,the surrounding of living,the working condition,individual habit and living habits.To prolong the time of living in the room after decoration and keep the room ventilation can decrease the adverse effects of decoration pollution.

Objective To observe the effect of neoadjuvant chemotherapy for patients with advanced cervical cancer.Methods According to the digital table ,106 patients with advanced cervical cancer were randomly divided into the two groups ,53 cases in each group .The observation group was given TP Scheme neoadjuvant chemotherapy before surgery ,the control group underwent surgery directly .The total effective rate of chemotherapy and the changes of diameter of tumor before and after chemotherapy were observed .The serum levels of vascular endothelial growth fac-tor(VEGF) and matrix metalloproteinase-9(MMP-9) of the observation group were detected ,and the operation condi-tions were compared between the two groups .Results After chemotherapy ,the total effective rate of the observation group was 60.4%.Before and after chemotherapy ,the average tumor diameter of the observation group was (5.24 ± 1.35)cm,(2.64 ±0.67)cm,respectively,the difference was significant (t=3.947,P<0.05).The operative time, blood loss and lymph node metastasis in the observation group were significantly less than those in the control group (t=3.725,5.392,χ2 =4.28,P<0.05 or P<0.01).After chemotherapy,the serum levels of VEGF and MMP-9 were significantly lower than that before chemotherapy (t=3.130,4.724,all P<0.05).Conclusion Neoadjuvant chemotherapy in the treatment of advanced cervical cancer can significantly reduce serum VEGF and MMP-9 expression.

Lymphocyte culture media are commonly supplemented With calf serum.The use of calf sera of different sources may introduce uncontrollable variables,which often make trobles in explaining the results.In this papor the influence of calf sera from two different supplies(serum A and B)on lymihocyte funetion assay in vitro was compared.It was found that no difference was observed in B lymohocyte pr- oliferative rosponse to Staphylococcus aureus Cowen strain l(SAC)or to goat F(ab) anti-human ? chain spocific antibody and in plaque-formation cell response induced by SAC or Pokeweed mitogen(PWM)or in PHA induced T cell proliferation in using calf serum A and B.However,in Con?A-driven T cell proliferation,serum B.However, in Con?A-driven T cell proliferation,serum B gave highor cpm m all three experim- ents.The results were 7934?3859?versus 1435?124(p