Three cases of intestinal T cell lymphoma(ITCL) were retrospectively reviewed in this study. Clinically, most patients with ITCL were middle aged males with abdominal pain, hematochezia,fever and weight loss. The outcome of treatment was worse with an extremely poor prognosis. The pathologic changes appeared to be the formation of intestianl ulcer manifested with multiplicity of shape,multifocal and unregularities. Tumor cells under microscopy were various obviously with diffused infiltration and medium to large cells were seen frequently. ITCL was often misdiagnosed because of clinical rarity and lack of characteristic manifestations, so physicians must pay more attention to the research of clinicopathological data,immunohistochemical features and gene type, so as to make early and correct diagnosis.

The prevalence of diabetes is reaching epidemic proportions worldwide.Elevated glucose levels and associated increases in blood pressure and dyslipidemia lead to long-term complications including cardiovascular disease,diabetic retinopathy,kidney disease,and nervous system damage.These complications are largely responsible for the great increase in morbidity and mortality seen in diabetes.Unfortunately,once established,diabetes is very diffi cult to treat,and it is currently exerting tremendous pressure on healthcare systems worldwide.For these reasons,diabetes prevention has become a key target for clinicians,patients and policymakers,and a number of potential strategies are under study.The purpose of this article is fi rst to discuss the defi ciency of current preventing strategies,and the potential role and the advantages of Traditional Chinese Medicine(TCM) to prevent diabetes.Following that,based on observational studies as well as on prospective trials,and with respect to the prevention and treatment of diabetes,the authors,therefore,suggest that the best way to approach prevention is through lifestyle modification guided by TCM theory.And those interventions should include not only herbs,but acupuncture,massage,food therapy and mind-body exercise,and they must examine cost-effectiveness as well.Future studies should also be designed with using such interventions and should be of suff icient duration to differentiate between genuine diabetes prevention as opposed to simple delay or masking of the disease.

Neural plasticity is one of the most important research area of developmental neurobiology. NMDA(N-Methyl-D-aspartate) receptor is one of the glutamate receptors in nervous system, which palys an important role in many biological and pathological changes, such as development of neural network, neural plasticity, learning and memory, degeneration of the neurons and so on. The studies on NMDA receptor with auditory plasticity and learning and memory were reviewed in order to make early intervention for hearing impaired children and provide a theoretical basis.
Auditory Perception ; Humans ; Learning ; Memory ; Nervous System ; Neuronal Plasticity ; Receptors, N-Methyl-D-Aspartate

OBJECTIVE: To explore the efficacy and feasibility of compound glycyrrhizin in combination with anisodamine for the treatment of allergic purpura. METHODS: 60 patients with allergic purpura were randomly divided into treatment group and control group.The control group was given only the conventional therapy while the treatment group was treated with compound glycyrrhizin plus anisodamine in addition to the conventional therapy as stated in the control group. The course of treatment for both groups was 10 continuous days. RESULTS: The total effective rates for the treatment group and the control group were 90% and 60% (P

Objective To investigate the relationship between the mutagenicity of carbamazepine (CBZ) and folic acid (FA), and to explore the mechanism of CBZ teratogensis and the prevention effect of the folic acid. Methods Peripheral blood lymphocyte chromosome aberration rate (CAR), sister chromatid exchange (SCE)frequencies, and serum FA levels have been studied in 15 CBZ -treated epileptic patients, 15 CBZ plus FA-treated epileptic patients The untreated epileptic patients and the health subjects were served as controls Results CAR and SCE frequencies were significantly higher in CBZ group as compared with the CBZ plus FA group and the controls ( P

0.05).Except that the wet weight of the epididymis in high-dose group of apigenin was significantly different compared with middle-dose group of apigenin(P 0.05).Cell cycle analysis showed that compared with the negative control group,the percent of diploid cells in low and high-dose group was decreased,the proportion of G0/G1 phase cells in low-dose group of apigenin was reduced(P

Objective To investigate the clinical characteristics of Landau-Kleffner syndrome.Methods The clinical data of 3 patients with Landau-Kleffner syndrome was analyzed retrospectively.Results The clinical features of 3 cases presented acquired aphasia,epileptic attack and psychical behaviour abnormality.The EEG showed foci spike wave discharge,while the CT and MRI examination were normal.The epileptic attacks were controlled after treatment,but the recovery of aphasia and psychical behaviour abnormality was poor.Conclusions Acquired aphasia and epileptic attack are the clinical characteristics of Landau-Kleffner syndrome.The EEG shows spike wave dischargeis.Partial recovery can be obtained post-treatment.

Objective To investigate the clinical features of limbic epilepsies and limbic status epilepticus.Methods The clinical data of two patients with limbic epilepsies and one patient with limbic status epilepticus were analysed retrospectively.Results 2 patients with limbic epilepsia were all young-aged onset of the disease.They manifested bouts of unconsciousness,nervous and fear,various automatism and autonomic nerves symptom.EEG showed spike discharge in unilateral or bilateral temporal area.MRI showed left hippocampns sclerosis in one case.Another case presented calcification focus in right internal temporal.One patient with limbic status epilepticus was middle-aged male,he manifested repeatedly onset of unconscious insanity,behavior disorders and psychiatric symptoms.There was over 30 min for once onset.EEG showed ? wave or ? wave in bilateral frontal and temporal area.MRI showed arachnoid cyst in left temporal lobe anterior.Three cases were controlled by Carbamazepine or Oxcarbazepine.Conclusion The clinical feature of limbic epilepsies and limbic status epilepticus have bouts of automatism,automic nerve symptom and psychiatric symptom attact,which have relation to impairment of hippocampus and almond body in interal temporal.

Objective To observe The liver lipogenic gene expression of animal model of phlegm and dampness syndrome. Methods According to the theory "Obese people have much more phlegm and dampness", the animal model of phlegm and dampness was built by high fat feeding. After 10 weeks' high fat feeding, we examined liver HE slice, the level of lipids in the normal and model group rats .The liver lipogenic gene expression including LXRα, SREBP-1c, and FAS were detected by fluorescence real time quantative PCR. Results Compared with that of the normal group rat, there was increasing lipids both in serum and liver in the model rats. There was typical appearance of fatty accumulation in the liver cells examined by liver HE staining. The expression of SREBP-Ic and FAS was much higher in phlegm and dampness group than that in the normal group, although there was no difference in the expression of LXRα. Conclusion The fatty accumulation of liver cell in phlegm and dampness group has a close relation to the enhancement of the liver lipoganic gene expression.

AIM: To study the influence of minimal modified low density lipoprotein (mmLDL) on plasminogen activator inhibitor-1 (PAI-1) activity, gene expression and regulation in human vascular endothelial cells. METHODS: The PAI-1 activity in human umbilical vein endothelial cells (HUVEC) culture medium was measured by chromogenic assay. The PAI-1 mRNA expression were determined by Northern blot. Using gene recombination techniques, four luciferase reporter gene plasmids containing different length of human PAI-1 gene promoter were constructed. Through the transient transfection analysis, the roles of AP-1 element(from -823 bp to -553 bp) in PAI-1 promoter have been determined. In order to further verify the role of AP-1 element, the three site-directed mutants were received using PCR and sequencing assay. RESULTS: The PAI-1 activity and mRNA level were increased when HUVECs were exposed to 50 mg/L mmLDL. At the same time, the AP-1 protein level was increased in nuclear. The induction by mmLDL were decreased markedly when the three AP-1 elements in PAI-1 promoter had been mutated, respectively. CONCLUSION: (1) mmLDL increased PAI-1 activity and mRNA expression in HUVEC. (2) Increase in PAI-1 activity induced by mmLDL was related to its mRNA expression. (3) Three AP-1 element in PAI-1 promoter may have an important role in PAI-1 gene transcription in endothelial cells induced by mmLDL.