Male Wistar rats were used to investigate the ultrastructure of the fibroblasts. The animals were sacrified at several time intervals after the collodion tubules were embedded subscutaneously on the backs, and the materials taken from the connective tissues around the collodion tubules were observed by light and electron microscopy. Six basic types of fibroblasts (little-differentiated fibroblast, young fibroblast, collagenoblast, myofibroblast, fibroclast and fibrocyte) were studied ultrastructurally. In each of its three phases (prophase, metaphase and telophase), the collagenoblast showed different functional conditions. The fibroclasts contain two subtypes, the phagocytosis and the lysosome subtypes, the former phagocytosing the collagen fibrils with a characteristic crossing banding and the latter phagocytosing the collagen fibrils which had been cleaved by the collagenase. The fibrocytes consist probably of two subtypes, the resting and aging subtypes. The observations demonstrate that the fibroblasts were derived from undifferentiated cells around capillaries and the little-differentiated fibroblasts are the youngest cell type of all fibroblasts. The collagenoblasts and fibroclasts are the main cells responsible for collagen biosynthesis and collagen degradation respectively. In the present paper a new concept, the "The Fibroblast System", has been proposed, which includes the six basic types of fibroblasts and there are not only structural but also functional relationships among them.

The antidepressant effects of the N-Isosuccinyl-dichlorocinnamo-ylamide ( 7903 ) , an analogue of piperine, upon 5 animal models were studied. The 7903 was found to have antidepressant effects on the models with doses less than TD50. The 7903 with the single dose, which did not increase the spontaneous motor activity of animals, could significantly decrease the duration of immobility of mice and rats in the forced-swimming test and that of mice in the tail-suspension test. The duration of the longest permanent immobility indaced by cornea electro-stimulation in mice was also decreased with the chronic administration ( 2 weeks ) of the 7903. And the hypothermia induced by reserpine could be antagonized by the 7903.

Objective To observe the effect of herbal plaster at acupoints for the excess syndrome of primary dysmenorrhea and its influence on prostaglandins.Methods The patients with of primary dysmenorrhea excess syndrome were randomized into treatment group(33 cases) and control group(31 cases).The former was treated by herbal plaster at acupoints while the latter treated by orally taking Tianqi Tongjing Capsule(Radix Notoginseng for Capsule Dysmenorrhea).Before and after the treatment,the pain scores and the accompanied symptoms were observed;and PGF2? and PGE2 of peripheral blood and renal and hepatic functions were detected.Results After treatment,the pain scores of both groups were significantly decreased(P

Objective: To evaluate the effect of Chinese herbal medicine on Chronic Periodontitid.(CP).Method:34 patients with CP were randomly divided into two groups.The herbal medicine was given to the experiment group for two months,while the other group was set as a blank control.The Periodontitid and laboratory test indexes such as PLP,PPDPAL,MD and Ca P,ALP of patients were measured before and after treatment.Results: The indexes of patients in the group of Chinese herbal medicine were statistically signifi cant in contrast with the control group(P

The influences of the N -Isosuccinyl - dichloro - cinnamoylamide (7903) on the NA and 5 -HT systems in the brain were studied. Acute administration of 7903 could significantly enhance the level of NA and 5 -HT in mice brain and cortex of rats, and the level of 5 -HT in the hyporthalamus of rats was tending to be enhanced. However, chronic administration of 7903 (two weeks ) could decrease the level of NA and the ra-tio of 5-HIAA/5-HT in the cortex of rats; Chronic administration of 7903 could also decrease the turnover of NA and 5- HT in mice brain, but had no effects on the special binding of ? - receptor to 3-H - DHA and that of 5 -HT receptor to H - ketanserine in the cortex of rats.

Objective To study the utility of brainstem auditory evoked potentials in the evaluation of children with cerebral palsy. Methods In a group of 86 cases of cerebral palsy aged 6～30 months and a control group of 60 normal children, the brainstem auditory evoked potentials were recorded and subsequently analyzed and evaluated correlatively with asphyxia during birth and their functional impairments (including the visual, speech impairment, epilepsy and eating dysfunction). Results The latencies of waves Ⅲ?Ⅴ,the interpeak latencies(IPLs) of waves Ⅲ-Ⅴof BAEP in children with cerebral palsy were often abnormal( P

To report one case of postoperative reconstruction of facial squamous cell carcinoma by cervicotho-racic flap and temporal flap in our hospital. Clinical symptoms of the patient are facial mass and tumor ulceration.The patient had chronic bronchitis. On admission, the right side of the patient face was found to have a mass of about 6. 5 cm X 5. 0 cm, and the middle is about 2. 5 cm X 2. 5 cm X 1. 0cm ulcer, the neck has no swollen lymphnodes by palpation. After imaging and pathological examination,the patient was diagnosed as right facial squamouscell carcinoma and chronic bronchitis.
Carcinoma, Squamous Cell ; surgery ; Face ; pathology ; surgery ; Humans ; Postoperative Period ; Reconstructive Surgical Procedures ; Surgical Flaps

AIM: To study the synergic antitumor effect of verapamil (VPL) and tumor necrosis factor alpha (TNF?). METHODS: In the presence of verapamil or verapami plus tumor necrosis factor, the proliferation, the expressions of c-myc and PCNA, the mean vessel density(MVD)of human hepatoma cell line(HepG 2) were studied in vivo and in vitro. RESULTS: It was demonstrated that the growth of HepG 2 was inhibited remarkably, under the presence of verapamil and TNF? simutaneously, the expressions of c-myc , PCNA and the MVD were also decreased. CONCLUSION: The calcium channel blocker can inhibit the proliferation of tumor and has a remarkable synergy with TNF?. [

By the application of modularization combination principle,a new type of field medical point operation instrument set is designed.It not only innovates the organization mode of the traditional field operation instrument case,meets the requirement of intensivization,portability and standardization but also improves the support efficiency of medical service.

The module of surgical instruments modularization based on the theory research are applied to the medical rescue of earthquake relief effort by the application of methods on practical demonstration,which solves the defects and inadequacies of the traditional surgical instruments box group field and validates the feasibility of practical application in the combination of modular design of surgical instruments,these can provide practical basis for new modules of field surgical instruments.