Objective To investigate the levels of interleukin-1?,interleukin-6,tumor necro- sis factor-? in preterm labor with intraamniotic infection(IAI).Methods Plasma and amniotic fluid were sampled from 30 women with preterm labor(Group A),31 women with term labor(Group B) and 46 women without labor but after 37 weeks(Group C).Interleukin-6 in blood,interleukin-1?, interleukin-6 and tumor necrosis factor-? in amniotic fluid were examined.IAI were diagnosed accord- ing to clinical criteria or bacterial culture or pathology.Results 1.The levels of IL-6 in blood in Group A were higher than in Group Band C(46.34 vs 20.53,6.67pg/ml,P

Objective: To establish the standard for the quality control of Dougenguanshitong granule.Methods: The TCL method was used to identify the Radix Ootoginseng and Dioscorea Bulbifera in the granule and the content of matrine in the granule was determined by the HPLC method.Results: The linear relationship of matrine was the range of 0.68-10.2?g(r=0.9997,n=6).The average recovery was 100.23% and RSD was 1.54%(n=6).Conclusion:The method is convenient,rapid,accurate and suitable for the quality control of Dougenguanshitong granule.

Objective To investigate the variation of cytokines IL-4, IL-1? and TNF-? before and after the onset of pregnancy induced hypertension (PIH) and to discuss the role of cytokine in the pathogenesis of PIH. Method A prospective cohort study of 550 pregnant women were followed. Plasma drawn from 25 women who developed moderate and severe PIH and 30 controls at 12~16 and 32~36 gestational weeks were analyzed. The concentrations of IL-4, IL-1? and TNF-? were analyzed using ELISA method. Results (1)In the second trimester, the plasma level of TNF-? in PIH group was significantly higher than control group(27.66 ng/L vs 17.80 ng/L, P

Objective To investigate the management of research instruments.Methods Scientific and effectual device management and technical training were established.Results The instruments availability and intact conditions including economic efficacy were greatly improved via scientific and effectual management in our neurosurgical institute.Conclusion Scientific standard and systematic management can not only ensure the optimal working conditions of research instruments for research work,but promote the equipment efficacy and increase economic returns.

0 05). For the average blood loss at 2 hour postpartum, it was 129 7 ml, 133 9 ml, 168 5 ml and 178 2 ml for group Ⅰ, Ⅱ, Ⅲ and Ⅳ respectively, while the total blood loss for the 4 groups was 243 3 ml, 242 9 ml, 308 1 ml, and 314 8 ml respectively. The average blood loss of group Ⅰ and Ⅱ was significantly less than group Ⅲ and Ⅳ ( P 0 05). The occurrences of postpartum hemorrhage (blood lose ≥400 ml) were 6 4%, 13 3%, 20 7% and 25 3% for group Ⅰ, Ⅱ, Ⅲ and Ⅳ respectively. There was no major adverse effects appeared. Conclusions Transamin is efficient and safe in reducing the postpartum blood loss. 1 0 g of Transamin has the best efficacy, and 0.5g of Transamin followed.

Objective To investigate the role of angiogenesis and expression of vascular endothelial growth factor (VEGF) in the pathophysiology of adenomyosis of the uterus. Methods The study included 32 patients with histologically proven adenomyosis and 30 patients with asymptomatic leiomyoma of the uterus. Immunohistochemical staining was used to detect VEGF expression in different parts of the uterus. A computerized morphometric study on the VEGF expression was performed. Results The VEGF H-Score of glandular cells in the endometrium of adenomyosis uterus [proliferative phase (9.6?1.4), secretory phase (11.7?1.6)] was much higher than that of leiomyoma uterus [proliferative phase (8.3?1.7),secretory phase (10.2?1.5)] (P0.05). The VEGF H-Score of myometrium around the ectopic lesions [proliferative phase (9.5?1.3), secretory phase (8.7?1.3)] was higher than that of normal myometrium [proliferative phase (4.8?1.9), secretory phase (4.5?1.4)] (P

ObjectiveTo observe the effect of extracorporeal shock wave therapy (ESWT) on managing heel pain. Methods22 patients were divided into 2 groups,12 cases in treatment group who accepted ESWT, 10 cases in control group.The intensity of morning pain on weight bearing, pain triggered by prolonged walking/standing, pain on tension and palpation tests were assessed by Visual Analogue Scale (VAS) before and after each treatment session, including the follow-up session,3 weeks after treatment. In addition, Mayo Clinical Scoring System (MCSS) was used to evaluate the treatment outcomes. ResultsAfter 3 weeks of treatment and 3 weeks' follow-up, the intensity of pain on tension test(P<0.05)as well as that on palpation test (P<0.01)decreased, the maximum duration of prolonged walking or standing (P<0.05)and MCSS scores (P<0.05)improved. Conclusions ESWT seems to be a more effective treatment modality for managing heel pain.

Objective To study the clinical characteristics,pathology,and treatment for papillary carcinoma of the breast.Methods The clinical data of 17 patients of papillary carcinoma of the breast admitted in the First Affiliated Hospital of Wen Zhou Medical College were retrospectively analyzed.Results Papillary carcinoma of the breast accounted for 0.64％ of all breast cancer cases hospitalized during last 10 years.All cases had palpable lumps in the breast.12 cases received modified radical mastectomy,2 cases received simple mastectomy,2 cases underwent breast conservation therapy,1 case underwent simple mastectomy plus sentinel lymph node biopsy.15 patients received postoperative chemotherapy,among those 5 cases also received radiotherapy.During a 32.5-month median follow-up ( 1 month to 8 years),one case with bone metastases died 2 years postoperatively and another one died of multimetastases 7 years later.Conclusions The prognosis of papillary carcinoma of the breast is closely related with its pathology type.For intraductal papillary carcinoma low-traumatic therapy is applicable,while in case of infiltrating papillary carcinoma or invasive micropapillary carcinoma ( IMPC ),more aggressive therapies like that adopted for infiltrating ductal carcinoma are recommended.

This paper, using acetylcholinesterase (AChE) histochemistry, brain-lesion and di-isopropylfluorophosphate (DFP) pretreatment techniques, studies AChE distribution in the tectum-nucleus isthmi systems in frogs and pigeons. In these two species of animals, the tectal laminae densely stained for AChE are roughly coincided with the retinotectal projections. Staining pattern in the frog nucleus isthmi consists of 3 areas with different staining intensities. The dorsolateral area being most densely stained. In pigeons, the nucleus isthmi pars parvocellularis (Ipc) and pars magnocellularis (Imc) are densely and evenly stained. Following local lesion of tectum, stainings in the frog nucleus isthmi and pigeon Ipc are topographically reduced or disappeared. DFP-treatment shows that tectal cells, with the exception of cells in layer III containing rich AChE, have moderate or low concentrations of AChE. The isthmic cells are rich in AChE. In the tectum-lesioned pigeons, AChE-stained isthmic cells in the topographical area are reduced in number and paler in color. These results suggest that in amphibians and birds both the tectoisthmic projection and the isthmotectal projection could be cholinergic pathways in nature.

Objective To evaluate the effectiveness and safety of triptorelin in the treatment of uterine leiomyoma. Methods A multi-center, prospective, randomly controlled clinical trial was carried out from Dec. 2002 to Mar. 2004 in three university hospitals. A total of 125 qualified patients with uterine leiomyoma were randomly divided into either triptorelin group (63 cases) treated with 3.75 mg triptorelin injected intramuscularly or leuprorelin group (62 cases) treated with 3.75 mg leuprorelin injected subcutaneously. Both drugs were injected every 28 days for a total of 3 months. Results All 125 patients finished the trial. The uterine volumes were similar before treatment between the triptorelin group and the leuprorelin group and were decreased significantly after drug therapy (P0.05).) The volumes of the largest leiomyoma decreased significantly after drug therapy (P0.05). Patients with serum level of 17?-estradiol 0.05). Dysmenorrhea, noncyclic pelvic pain and pressure-like symptoms were relieved quickly and remarkably in both groups after treatment. The rates of adverse event occurred in 71% of patients in both groups. The main side effects included flare-up effects and hypoestrogenic symptoms. Nine patients in the triptorelin group and 6 in the leuprorelin group received add-back therapy with tibolone 1.25-2.50 mg/d because of remarkable climacteric-like symptoms. Conclusion Treatment of uterine leiomyoma with triptorelin for 3 months is both effective and safe in Chinese women.