Objective To investigate the effects of percutaneous radio frequency ablation of liver cancer, and evaluate the indications, contraindications, and side effects. Methods One hundred and fifty four patients with hepatocellular carcinoma or metastases liver cancer, with the average diameter of the tumours 7.07 cm were treated with by radio frequency RF 2000TM instrument, the results were evaluated. Results Average theraputic time was 1.18 times, the theraputic point was 5.74. The symptoms were improved after therapy, and the average concentration of AFP was droped from 1 553.68 ng/ml to 883.70 ng/ml. The percentage of tumour reduction was 56.8%. There were no serious complications observed. Conclusion Percutaneous radio frequency ablation of liver cancer is a simple, safe and effective method. For larger liver cancer several times action will be needed, or other intervantion therapy is added to enhance effectiveness.

Objective To investigate the correlation between ACE gene polymorphisms and stroke of Han nationality people in Fangshan district of Beijing. Methods The Insertion/Deletion(ID) polymorphisms of ACE gene were detected in 63 patients with cerebral hemorrhage,and 713 patients with cerebral infarction and 235 health control by polymerase chain reaction(PCR). We observed the frequencies of genotype of deletion homozygote(DD),insertion homozygote(II) and insertion/deletion heterozygote (ID) and the alleles of D and I. Also we analyzed the association among I/D polymorphisms of ACE gene with serum glucose(GLU),triglyceride(TG),cholesterol(TC) levels. Results There was no significant difference in the frequencies of both genotypes of DD,ID,II and alleles of D and I in three groups. The serum GLU levels in patients carrying ID,II genotype were higher than those in healthy control(P

Objective To investigate the physiological characteristics and the association with low prevalence of hypertension in "desert people" ,as an isolated population,in Taklimakan Desert.Methods All data were obtained from each person by questionnaire and standardized physical examinations. Total 469 subjects received examinations,including 359 subjects of "desert people" (M/F=205/154),aged from 15~99 years; 101 subjects of Uyghur from Yutian county (M/F=51/50),aged from 20~85 years,as controls. Some parameters :TC,TG,LDL-C,HDL-C,Apo-A,Apo-B,Lp-a,BUN,UA and CRE were determined. The statistical analysis was performed with SAS9.1.3 Version (Inititute Inc. Cary,NC. USA). Continuos values were expressed as mean?SD.Differences between groups were examined by student's t test,and statistical difference was considered when the P value was less than 0.05.Results 1)The height in "desert people" was significantly taller than that in controls.P value was 0.0317 for male and P60 years,P value was 0.0127 and 0.0443,respectively.(3)The prevalence of hypertension in "desert people" was 7%(24/359),that was significantly lower than that in controls(30.7%,31/101),P

OBJECTIVETo investigate the expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and explore the clinicopathological implications.

METHODSImmunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the expressions of SFRP4 and DKK1 in 66 cervical squamous cell carcinoma and 26 normal cervical specimens.

RESULTSSFRP4 expression was significantly higher (P<0.01) and DKK1 expression was significantly lower (P<0.05) in the carcinoma tissues than in normal cervical tissues. DKK1 was negatively correlated with SFRP4 in the carcinoma tissues (P<0.01), and their expressions were associated with the clinical stages, tumor differentiation, depth of invasion and lymph node metastasis of the tumors (P<0.05).

CONCLUSIONSFRP4 and DKK1, the upstream components of the Wnt pathway, play a key role in the tumorigenesis of cervical squamous cell carcinoma, and their expressions are associated with the clinicopathological features of the malignancy.

Carcinoma, Squamous Cell ; metabolism ; Female ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins ; metabolism ; Lymphatic Metastasis ; Proto-Oncogene Proteins ; metabolism ; Uterine Cervical Neoplasms ; metabolism