Objective To explore the significance of interleukin -35 (IL -35)in serum of patients with severe hepatitis.Methods Collected 39 cases of chronic hepatitis B(CHB)patients and severe hepatitis,and col-lected 19 cases of healthy control's(HC)peripheral blood at the same time.ELISA method was used to detect IL -35 levels.Results IL -35 in CHB and severe hepatitis group [(483.5 ±280.7)ng/mL and (277.9 ±248.7)ng/mL] were higher than HC group (50.5 ±47.8)ng/mL(t =2.089,3.303,P =0.044,0.002).In severe hepatitis group, the IL -35 levels in survivors group (305.3 ±301.2)ng/mL was higher than death group (78.7 ±33.2)ng/mL (P =0.012).IL -35 was positively correlated with ALT and AST,the correlation coefficient were 0.649 and 0.599. Conclusion IL -35 is involved in the pathogenesis of hepatitis B process,the low serum IL -35 levels in severe hepatitis patients may herald a bad prognosis.

Objective To explore the changes of interleukin -33 in serum of patients with chronic severe hepatitis B.Methods 25 patients with mild chronic hepatitis B ( MCHB group) and 25 patients with severe chronic hepatitis B(SCHB group) were collected.18 healthy people were collected as control (HC group).ELISA method was used to detect IL -33 level in peripheral blood .Results The IL-33 levels in MCHB and SCHB group were (11.7 ±6.9)ng/L and (16.5 ±9.1)ng/L,respectively,which were significantly higher than (5.1 ±2.9)ng/L in HC group(t=4.037,5.434,P=0.000,0.000).The IL-33 level in MCHB group was lower than that in SCHB group(t=2.108,P=0.040).The IL-33 level was positively correlated with ALT ,AST and HBV DNA(r=0.526, 0.568,0.285,P=0.000,0.000,0.045 ).Conclusion IL -33 is involved in the pathogenesis of hepatitis B . IL-33 plays an important role in HBV -relate injury.