Objective:To study the influence of regional population and health input on public hospital operation by empirical analysis.Methods:Taking Chifeng Municipal Hospital and Xilingol League Hospital as samples and applies contrastive analysis to this essay.Results:Chifeng Municipal Hospital had 4 times of patients and 2 times of total health input than Xilingol League Hospital.Chifeng Municipal Hospital could better receive the fund for general hospital operation and had little reliability on the fiscal.Conclusion:The public hospitals located in low population density area could not adopt the same medical reform policies as other hospitals in different areas.It needed to give support for medical insurance payment and price adjustment,especially for fiscal compensation.