Medulloblastoma is the most common malignant tumor of childhood.Over the past decade,progress in improving survival using conventional therapies has stalled.As advances in the molecular and genetic profiling of pediatric medulloblastoma evolve,associations with prognosis and treatment are found and research is directed at molecular therapies.The vast amount of genomic and molecular data generated over the last years encourages optimism that improved new molecular targets will improve outcomes.

95 probands' family frees of MPA have been studied by the methods of simple segregation analysis and estimation of heritability. The result shows that MPA may be caused by different hereditary patterns. In the families with affected parents and vertical transmission. MPA may be caused by an autosomal dominant (AD) gene, making up 56.84% (AD) and 2.11% (reduced penetrance). It also shows that MPA may be due to polygenic inheritance.

Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric illness in children.ADHD is characterized by inattention ,hyperactivity and impulsivity, which can seriously disturb patients'study and work.Patients with ADHD suffer from impaired cognitive function.The conventional neuropsychological tests can assess the cognitive function of patients, but it can be affected by subjective factors.Electrophysiological techniques and brain image technology, however, can detect the cognitive function of ADHD patients objectively.In recent years, researchers have made great processes in exploring the cognitive function of ADHD patients with the help of these technologies.And this review summarizes the progresses of cognitive function detecting techniques in ADHD.

Objective To evaluate the value of ultrasound in the diagnosis of abortion in the early pregnancy.Methods 653 women who had the symptoms such as transvaginal blooding and abdominal pain in the early pregnancy were underwent transvaginal sonography or abdominal sonography,followed up and observed them in different types in the coming days.Results Among the 653 early-abortion women,there were threatened-abortion in 298 cases,incomplete-abortion in 114 cases, complete-abortion in 56 cases, inevitable-abortion in 141 cases and delayed-abortion in 44 cases.Conclusion Clinical trials showed that using ultrasound to check for abortion in the early stages has its value in practice.Because it makes clinic can be diagnosed and treated in time.

OBJECTIVE:To establish a HPLC method for the determination of in vitro drug release of Baicalin liposomes.METHODS:The separation was performed on a C18 column(150mm?4.6mm,5?m)at 25℃;the mobile phase was composed of methanol-water-phosohoric acid(47∶53∶0.2)at a flow rate of 1.0mL?min-1.The ultraviolet wavelength was set at 280nm and the sample size was 10?L.RESULTS:The calibration curve showed good linearity in the range of 1.01～80.80?g?mL-1(r=0.999 8)and the average recovery rate was 100.05%(RSD=0.93%).CONCLUSION:The method is sensitive,simple and accurate,and applicable for the study of in vitro drug release of Baicalin liposomes.

In recent years,the research of Kangai injection,which is one of TCM anti-tumor injections,has been recognized as the most active areas of tumor treatment.To lung cancer patients,solo Kangai injection therapy could improve their quaility of life.It can also increase the efficiency,enhance the immune function,decrease the incidence of toxicities and adverse reactions when it has been combined with chemotherapy or radiotherapy.Overall,Kangai injection is effective in improving therapeutic effect and reducing side-effects of chemotherapy or radiotherapy.This article will discuss about recent research status of Kangai injection in the treatment of lung cancer.

Objective To evaluate the therapeutic efficacy and safety of Wenxin Particle combined with amiodarone in the treatment of premature ventricular beats.Methods 78 cases with premature ventricular beats were divided into observation group(n=40)and control group(n=38).The observation group was treated with Wenxin Particle and amiodarone,the control group was treated amiodarone with only.The improvement of clinical symptoms and premature ventricular beats and the side effects were observed.Results Total effective rate was 78.94％ in control group,92.50％ in observation group.There was a significantly statistical difference between two groups(P＜0.05).Conclusion Wenxin Particle combined with amiodarone in treating premature ventricular beats can improve the clinical effect and have no obvious side effect,so it is worth being used widely.

Purpose　To explore the observation to the growth, development, and the ovulation process of ovarian follicle through B-mode ultrasound and the value in the treatment of ovulation obstructive barrenness. Methods　Monitor through B-mode ultrasound the development of ovarian follicle to 52 cases patients with ovulation obstructive barrenness from the nineth day of menstruation, mainly recording the umbers of ovarian follicle in ovarium and the numerial number in length and breadth. Results　Through induced ovulation to 52 cases patients, there were 37 cases ovulators whose ovarian follicle were mature, account for 71% and there were 28 cases of fertilized patients. Conclusion　B-mode ultrasound is a valuable medium to monitor growth and development of ovarian follicle and is of great importance in the treatment to ovulation obstructive barrenness.

Aquaporins,known as a family of water channel proteins,are crucial factors involved in colonic transmembrane water transport and play important roles in maintaining the homeostasis of internal and external environment of intestinal cells and modulating enteric nerve functions. Diarrhea-predominant irritable bowel syndrome( IBS-D)is a commonly seen gastrointestinal functional disorder in clinical practice. Recently,there are more and more researches focusing on the roles of aquaporins in IBS-D,however,mechanisms of its protective or damaging effects on IBS-D are still not clear. In this review article,the progress of research on the modulatory effect of aquaporins in IBS-D was summarized.

Objective To confirm the risk factors of poor prognosis in patients with severe acute epiglottitis by comparing symptoms and results of laboratory tests.Methods A total of 698 patients with acute epiglottitis from outpatient and emergency room from 1995 to 2014 were retrospectively studied.These patients were divided into severe or mild group as per the means of treatment of airway including invasive (n =115)and non-invasive (n =583).The past history,general conditions and laboratory tests were compared between the two groups by chi-square or t test;the spearman correlation between the degree of dyspnea and epiglottis edema was analyzed,and the risk factors of poor prognosis were detected by logistic regression.Results The ratio of male to female was 1.366/1.There was a high prevalence of sever acute epiglottitis in spring,winter and at night, respectively.More smokers were found in the severe group compared with the mild group (χ2 =41.957,P <0.01).Severe dyspnea and low PaO2 (r =0.573,P <0.01),but not the poor grading of epiglottis edema evaluated by pharyngo-fiberoscope (r =-0.024,P =0.525),were correlated with poor prognosis.Male (OR =1.84,95%CI:1.41 -3.22,P =0.001),an attack at night (OR =2.61,95%CI:1.98 -3.16),P =0.07), smoker (OR =1.63,95%CI:1.05 -3.39,P =0.04)and low PaO2 (OR =2.97,95%CI:1.58 -4.49,P =0.02)were independent risk factors for a poor prognosis.Conclusions Male,an attack at night,smoker and low PaO2 were independent risk factors for a poor prognosis of acute epiglottitis.A critical care should be given to patients with those risk factors,even their epiglottis edema was not very serious.