1.Effects of Naomaikang on the Platelet Aggregation Rate and Pathomorphological Changes of Experimental Atherosclerosis Rabbits
Qiang FENG ; Gaimei WU ; Shunyi LU
China Pharmacy 2001;0(11):-
OBJECTIVE:To investigate the inhibiting effect of Naomaikang(NMK) on atherosclerosis(AS) METHODS:Healthy male california rabbits were randomized into 5 groups(n=10):normal group,model group,Fenofibrate group,NMK groupⅠ(2ml) and NMK group Ⅱ(1ml) The rabbits in each group,except the normal one,were fed with hypercholestrol diet and the medicines were given to the other three groups at the same time The blood of each group was sampled for determining the platelet aggregation rate(PAR) before and after experiment The aorta of rabbit in each group was dissected out and stained with oil red 0,then the areas and incidences of plaque on aorta wall were calculated,the aortic arch was taken to observe under the light and electron microscopes RESULTS:The PAR in model group was significantly increased compared with those in other groups(P
2.Discussion on reinforcing-reducing manipulations of acupuncture in Internal Classic.
Chinese Acupuncture & Moxibustion 2009;29(10):850-853
To study and analyze the reinforcing-reducing manipulations of acupuncture in Internal Classic. The major methods of reinforcing-reducing manipulations of acupuncture in Internal Classic were reinforcing-reducing by manipulating the needle in cooperation with the patient's respiration, reinforcing-reducing effect induced by slow and quick manipulation of needle, and open-close reinforcing-reducing manipulation, these three methods were usually applied in combination. All of reinforcing-reducing manipulations should be based on the principle of puncturing along and against the flowing direction of the meridian qi. Mastering the reinforcing-reducing manipulations of acupuncture in Internal Classic will contribute to the improvement of therapeutic effects in clinical practice.
Acupuncture Therapy
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history
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methods
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China
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History, Ancient
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Humans
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Medicine in Literature
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Medicine, Chinese Traditional
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history
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methods
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Needles
3. Diagnosis and treatment of colorectal cancer by reduced port laparoscopic radical resection
Junsheng LU ; Song MA ; Xing MU ; Pengfei ZHANG ; Jianwei YANG ; Qiuming WU ; Hongqi ZHAO
Chinese Journal of Geriatrics 2019;38(9):1037-1040
Objective:
To investigate the clinical efficacy of reduced port laparoscopic radical resection on colorectal cancer.
Methods:
Clinical data of 46 patients with colorectal cancer undergoing reduced port laparoscopic radical resection were retrospectively analyzed.
Results:
All of 46 patients underwent laparoscopic surgery, with an average operation time of 206 minutes, an average intraoperative bleeding of 56 ml, an average number of lymph nodes removement of 12/case (ranged from 6 to 21). One case had incision infection, 2 cases had anastomotic leakage, and they all recovered and discharged after treatment.
Conclusions
Reduced port laparoscopic radical resection of colorectal cancer is safe and feasible, reduces labor costs, and has a good clinical efficacy, which is worthy of clinical promotion.
4.Adverse reaction induced by licorice preparations: clinical analysis of 93 cases.
Min MAO ; Wei LI ; Wei WANG ; Shu-Xia WANG ; Jin LU ; Zhang-Fu CHANG
China Journal of Chinese Materia Medica 2013;38(21):3768-3772
Licorice is a traditional Chinese medicine commonly used in clinic. The products,what contain licorice or licorice extract, has early been involved in the field of cosmetics except for the field of pharmaceuticals and food. Consequently, the reporting on adverse reactions induced by licorice preparations are more frequent. Based on the clinical data of licorice preparations adverse reactions, we described the characteristics of the licorice-related adverse reactions, and proposed specific measures to reduce the incidence of adverse reactions, provided a reference for the rational use of licorice preparations.
Adult
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Drug Therapy
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Drug-Related Side Effects and Adverse Reactions
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etiology
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Drugs, Chinese Herbal
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administration & dosage
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adverse effects
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Female
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Glycyrrhiza
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chemistry
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Humans
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Male
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Middle Aged
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Young Adult
5.Systematic Evaluation of Clinical Efficacy and Safety of Traditional Chinese Medicine for Post Stroke Cognitive Impairment
Wei SHEN ; Zi-xiu ZENG ; Xiang-lan JIN ; Yan LU ; Ying WANG ; Shi-xin LI ; Shi-jiao ZHAO ; Hui MEN ; Ming-quan LI ; Jian-jun ZHAO ; Hu ZHANG ; Zhen-yao WANG ; Jian YANG ; Xin XIONG ; Shang-zhen YU ; Qing SHI ; Yun-ling ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(11):185-193
Objective:To evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of post stroke cognitive impairment (PSCI). Method:Seven databases, including CNKI, WanFang, VIP, CBM, PubMed, The Cochrane library and ClinicalTrials.gov, were electronically searched for relevant randomized controlled trials (RCTs) of TCM in the treatment of PSCI. The Cochrane risk of bias assessment tool was used to evaluate the methodological quality of the included studies, descriptive analysis was carried out on the included studies, and the Meta quantitative analysis was carried out with RevMan 5.3 software. Result:A total of 16 RCTs were included with 1 296 participants, and they were assigned to the intervention group (
6.Effect of acupuncture on intestinal flora in rats with stress gastric ulcer.
Liu-Jing WANG ; Ting XUE ; Ying-Qi WU ; Jia-Yu ZHAO ; Tu-Nan WANG ; Jing-Ting LI ; Chen-Lu FU ; Jia-Jia MA ; Li-Ping ZHANG ; Yi-Xuan SHAO ; Yi-Chen YANG ; Zi-Xian ZHOU ; Hui-Fang MA
Chinese Acupuncture & Moxibustion 2020;40(5):526-532
OBJECTIVE:
To observe the effect of acupuncture at "Baihui" (GV 20), "Zhongwan" (CV 12) and "Zusanli" (ST 36) on intestinal flora in rats with stress gastric ulcer (SGU) , and to explore the mechanism of acupuncture promoting SGU recovery.
METHODS:
Thirty-one SPF SD rats were randomly divided into a control group (7 rats), a model control group (8 rats), an acupuncture group (8 rats) and a medication group (8 rats). The rats in the model group, acupuncture group and medication group were selected to applied the improved restraint water-immersion stress method to establish the SGU model. After modeling, the rats in the control group and model group were fixed and restrained for 20 min every day for a total of 5 days; the rats in the acupuncture group were intervented with acupuncture at "Baihui" (GV 20), "Zhongwan" (CV 12) and "Zusanli" (ST 36), once a day, 20 min each time, and twisting needle for 30 s every 5 min for a total of 5 days; the rats in the medication group were gavaged by solution of omeprazole enteric-coated tablet (200 mg/mL), 2 mL for each rat, once a day. Guth method was used to calculate the gastric mucosal damage index (GMDI), HE staining was used to observe the pathological changes of gastric mucosa, and 16SrDNA identification was used to detect the structural abundance of intestinal flora.
RESULTS:
Compared with the control group, the GMDI of rats in the model group was increased (<0.01), the gastric mucosal pathological changes were significant, and the intestinal flora richness index Chao1, Observed species and diversity index Shannon were all decreased (<0.05), the diversity index Simpson was increased (<0.05). Compared with the model group, the GMDI of rats in the acupuncture group and medication group was reduced (<0.01, <0.05), the gastric mucosal damage degree was reduced, and the intestinal flora richness index Chao1, Observed species and diversity index Shannon were all increased (<0.05) and the diversity index Simpson decreased (<0.05). Compared with the medication group, the GMDI of rats in the acupuncture group was reduced (<0.01), the recovery of gastric mucosal injury was better than that of the medication group.
CONCLUSION
Acupuncture can effectively improve gastric mucosal injury of SGU, and the mechanism may be related to increasing the diversity of intestinal flora and promoting the correction of the disordered intestinal flora.
Acupuncture Points
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Acupuncture Therapy
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Animals
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Gastrointestinal Microbiome
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Random Allocation
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Rats
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Rats, Sprague-Dawley
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Stomach Ulcer
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microbiology
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therapy
7.Incidence of Bone Marrow Involvement in Different Pathological Type Lymphoma Patients.
Qing CHEN ; Lu-Ting ZHU ; Xi-Nan CEN ; Ze-Yin LIANG ; Jin-Ping OU ; Li-Hong WANG ; Wen-Sheng WANG ; Wei LIU ; Zhi-Xiang QIU ; Yu-Jun DONG ; Mang-Ju WANG ; Yu-Hua SUN ; Yue YIN ; Qian WANG ; Han-Yun REN
Journal of Experimental Hematology 2018;26(3):765-771
OBJECTIVETo analyze the incidence of bone marrow involvement in patients with different pathological types of lymphoma.
METHODSThe results of bone marrow tests including bone marrow aspiration(BMA), flow cytometry detection, bone marrow biopsy(BMB) and F-FDG PET/CT, were analyzed retrospectively in 702 cases of newly diagnosed lymphoma with bone marrow assessment in our hospital from October 2000 to September 2016. If one of the above-mentioned 4 tests showed positive, the lymphoma patient was judged as bone marrow involved.
RESULTSThe incidence of bone marrow involvement (BMI ) in the patients with NHL was much higher than that in patients with HL [32.6 %(201/616) vs 15%(13/86)](P<0.05). For patients with NHL, the incidence of bone marrow involvement in B-cell lymphoma was higher than that in T-cell lymphoma (37.0% vs 22.6%)(P<0.05). According to different pathological types, the incidences of BMI in the patient with mantle cell lymphoma, hepatosplenic T-cell lymphoma, diffuse large B-cell lymphoma (DLBCL) and follical lymphoma (FL) were 88% (25/22), 100% (5/5), 21.8% (56/257), and 38.5% (15/39) , respectively.
CONCLUSIONThe incidence of bone marrow involvement varies in different pathological types of lymphoma.Bone marrow assessment has significant importance for stading of newly diagnosed lymphoma patients.
Biopsy ; Bone Marrow ; Fluorodeoxyglucose F18 ; Humans ; Incidence ; Lymphoma ; Positron Emission Tomography Computed Tomography ; Retrospective Studies
8.Characteristics, Management, and Outcomes of Acute Heart Failure in the Emergency Department: A Multicenter Registry Study with 1-year Follow-up in a Chinese Cohort in Beijing.
Guo-Gan WANG ; Si-Jia WANG ; Jian QIN ; Chun-Sheng LI ; Xue-Zhong YU ; Hong SHEN ; Li-Pei YANG ; Yan FU ; Ya-An ZHENG ; Bin ZHAO ; Dong-Min YU ; Fu-Jun QIN ; De-Gui ZHOU ; Ying LI ; Fu-Jun LIU ; Wei LI ; Wei ZHAO ; Xin GAO ; Zheng WANG ; Ming JIN ; Hong ZENG ; Yi LI ; Guo-Xing WANG ; Hong ZHOU ; Xiao-Lu SUN ; Peng-Bo WANG ; Kam-Sang WOO
Chinese Medical Journal 2017;130(16):1894-1901
BACKGROUNDThe emergency department (ED) has a pivotal influence on the management of acute heart failure (AHF), but data concerning current ED management are scarce. This Beijing AHF Registry Study investigated the characteristics, ED management, and short- and long-term clinical outcomes of AHF.
METHODSThis prospective, multicenter, observational study consecutively enrolled 3335 AHF patients who visited 14 EDs in Beijing from January 1, 2011, to September 23, 2012. Baseline data on characteristics and management were collected in the EDs. Follow-up data on death and readmissions were collected until November 31, 2013, with a response rate of 92.80%. The data were reported as median (interquartile range) for the continuous variables, or as number (percentage) for the categorical variables.
RESULTSThe median age of the enrolled patients was 71 (58-79) years, and 46.84% were women. In patients with AHF, coronary heart disease (43.27%) was the most common etiology, and myocardium ischemia (30.22%) was the main precipitant. Most of the patients in the ED received intravenous treatments, including diuretics (79.28%) and vasodilators (74.90%). Fewer patients in the ED received neurohormonal antagonists, and 25.94%, 31.12%, and 33.73% of patients received angiotensin converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers, and spironolactone, respectively. The proportions of patients who were admitted, discharged, left against medical advice, and died were 55.53%, 33.58%, 7.08%, and 3.81%, respectively. All-cause mortalities at 30 days and 1 year were 15.30% and 32.27%, respectively.
CONCLUSIONSSubstantial details on characteristics and ED management of AHF were investigated. The clinical outcomes of AHF patients were dismal. Thus, further investigations of ED-based therapeutic approaches for AHF are needed.