Objective To discuss the application effect of brain natriuretic peptide (BNP)and QRS wave in nursing intervention of postmenopausal women with heart failure.Methods 85 postmenopausal women with heart failure in our department were chosen.43 patients in the control group were given routine nursing,42 patients in the observation group were given pertinent nursing according to BNP concentration and QRS wave.The alleviation rate of symptoms,reoccurrence rate of heart failure,mortality rate,NP concentration and QRS wave time limit and hospitalization days were compared between two groups.Results The reoccurrence rate of heart failure,mortality rate,NP concentration and QRS wave time limit and hospitalization days in the observation group were lower than those of the control group,but the alleviation rate of symptoms was higher than that of the observation group.Conclusions To give pertinent nursing according to BNP concentration and QRS wave for postmenopausal women with heart failure can alleviate symptoms,decrease attack of heart failure,shorten hospitalization days,improve cardiac function and prognosis,which is worthy of clinical application.

To study the effect of genistein on the proliferation of cardiac fibroblasts(CF), CFs were cultured from neonatal rat hearts, DNA synthesis of the cells was determined by incorporation of ［3H］TdR into DNA, the cell cycle was measured by flow cytometric analysis. Genistein(0.5－50 μmol*L-1) attenuated 2.5% fetal calf serum-induced proliferation of CF in concentration-dependent manner. Genistein(50 μmol*L-1) arrested CF cell progression at G2/M phase. The results suggest that genistein be a potential substance for treatment of cardiac fibrosis.