Purpose　The aim is to increase stability and to s olve the problem of splitting of human serum γ-globulin products.Methods 　Fibrinolysin and profibrinolysin in the human serum γ-globulin p roducts were absorbed with L-lysine-Sepharose 4B.Results　Compared with the unabsorbed products, the splitting degree of the absorbed pr oducts decreased obviously.Conclusion　In manufacture of human serum γ-globulin products,absorbing fibrinolysin and profibrinolysin with L -lysine-Sepharose 4B may increase stability of the product.It was an effecti ve method to improve the quality of product.