Objective To obstor.e analgesic effect of cancer pain by radiation of acupoint with HPD millimeter-wave. Methol One 100patlents with serious cancer pain were treated by HPD millmeter-wave instrument (MW group) 30 minuies each time once a day. The radiatnt heads were put on the acupoints according to channeis. 40 patients with serious cancer pain accepting drug treamtment as control groud. The patieuts were evaluated one week after the treatment. Result Pain was signficantly relieved in 27 patients(27%)and decreased in 40 cases(40%) in millimeter wave group. Total analgesic rate was 67% (67/100)in MW group. Pain was relieved in 4 cases(10%) in control group(P＜0.001) Conclusion Radiation of acupoint with millimeter-wave is a safe, effective, and prompt method for cancer pain.

Objective To establish the degree of gray incidence model of Gentiana officinalis H.Smith. from differenct producing areas of Gansu Province and conduct quality evaluation. Methods Ten samples of Gentiana officinalis H.Smith. from different producing areas in Gansu Province were collected and the gentiopicroside, total iridoid gycoside, extractives, total ash, acid-insoluble ash content of Gentiana officinalis H.Smith were tested. The quality evaluation of grey incidence model of Gentiana officinalis H.Smith. was established by grey incidence model. Results The relative correlation degrees of all evaluation items were in the range of 0.394–0.652. Among them, the relative correlation degree of samples from 6 producint areas were greater than 0.50, which had high quality evaluation. The relative correlation degrees of the rest samples from other producing areas were less than 0.50, which had low quality evaluation. The sample of Gentiana officinalis H.Smith. from Zhuoni County Liulin Township Observatory had the most highly correlated with the optimal reference sequence (0.652) and so the best in quality;The sample of Gentiana officinalis H.Smith. from Zhang County Sancha Town Langwang Ditch had the most lowly correlated with the optimal reference sequence (0.394) and so the worst in quality. Conclusion This method and quality evaluation model can be used for the quality evaluation for Gentiana officinalis H.Smith., which can provide acertain experimental basis for the development and utilization of new resources.

Objective:To explore the effectiveness of evaluating voice disorders in dysarthria patients after brain injury using speech production measurements and analyze their phonics characteristics.Methods:Twenty-nine patients were divided into a severe dysarthria group ( n=19) and a mild dysarthria group ( n=10) through the subjective evaluation of their speech, and then evaluated using a computer speech monitor. The maximum phonation time (MPT), maximum counting ability (MCA), basic frequency (F0), standard deviation of F0 (F0SD), F0 range, intensity, formant, and the distance of jaw and tongue movements were recorded. Results:All of the patients displayed abnormal MPTs and MCAs, with the average MPT and MCA of the severe dysarthria group significantly lower than the mild group′s averages. In the severe dysarthria group, the abnormal F0s, F0SDs, F2(i)s and tongue movement distances were significantly greater than in the mild group.Conclusions:Speech production measurements can be applied to evaluate the speech dysarthria patients after brain injury. It is very common for such patients to have impaired speech and respiratory function, so this is worthy of attention.

Objective To observe the effect of exsanguination at jing points and auricular tips on antipyretic effect and inflammation factors level in patients with fever caused by coronavirus disease 2019(COVID-19).Methods A retrospective study was conducted.A total of 521 febrile patients with COVID-19 admitted to the Affiliated Hospital of Nanjing University of Chinese Medicine from January 1 to 10,2023 were selected as the study subjects.The patients were divided into the control group(treated with conventional treatment)and the experimental group(treated with exsanguination of jing points and auricular tips based on the control group)according to whether they received traditional Chinese medicine(TCM)exsanguination treatment.The body temperature before treatment and 30 minutes and 4 hours,24 hours after treatment,the immediate(within 30 minutes)antipyrexia efficiency,the time of body temperature returning to normal,and the levels of inflammatory factors before treatment and 48 hours after treatment were collected,and the differences between the two groups were compared.According to the standard of fever relief≥1℃within 4 hours,the differences of the average onset time of fever and the rate of fever relief at 2.5,3 and 4 hours after treatment were compared between the two groups.Kaplan-Meier curve was drawn to analyze the change of 4-hour antipyrexia rate in the two groups before and after matching.Results A total of 169 cases in the experimental group and 352 cases in the control group were finally included.Because this study was retrospective,there were significant differences in the course of disease and underlying diseases(chronic bronchitis,diabetes,renal insufficiency,hepatobiliary diseases)between the two groups at baseline(all P＜0.05).In order to reduce the differences,the above 4 factors were included in the predictor variables,and a 1∶1 propensity matching was performed to match 166 pairs of case samples,which were comparable.The result showed body temperature of the two groups gradually decreased with the extension of time,and the body temperature of the experimental group was significantly lower than that of the control group at each time point(℃:30 minutes was 38.32±0.22 vs.38.43±0.24,4 hours was 37.67±0.32 vs.38.13±0.51,24 hours was 37.03±0.38 vs.37.14±0.51,all P＜0.05),the immediate antipyrexia efficiency was significantly higher than that of the control time group[63.86%(106/166)vs.44.58%(74/166),P＜0.05],and the time of body temperature recovery to normal was significantly shorter than that of the control group(hours:19.25±7.79 vs.38.90±17.17,P＜0.05).In terms of the 4 hours antipyretic onset dynamic time,the average antipyretic onset time of the experimental group was significantly shorter than that of the control group[hours:4.39(4.11,4.68)vs.7.16(6.71,7.61),P＜0.05],the fever relief rates at 2.5,3 and 4 hours were significantly higher than those in the control group[6.63%(11/166)vs.0.60%(1/166),24.10%(40/166)vs.4.82%(8/166),74.10%(123/166)vs.38.55%(64/166),respectively,all P＜0.05].Kaplan-Meier curve analysis showed that there were statistically significant differences in 4 hours fever reduction rates between the two groups before and after matching(all P＜0.05).In terms of inflammatory factors,high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups after treatment were significantly lower than those before treatment[hs-CRP(mg/L):control group was 32.03±15.38 vs.79.78±13.34,experimental group was 33.21±16.07 vs.80.03±14.66;TNF-α(μg/L):control group 2.91±0.88 vs.5.09±0.95,experimental group 2.83±0.98 vs.5.10±0.87;IL-6(ng/L):control group was 96.30±48.12 vs.206.48±56.70,experimental group was 94.01±45.13 vs.202.38±55.38,all P＜0.05],but there was no significant difference in the levels of the above indicators between the two groups after treatment.Conclusion Exsanguination at the jing points and auricular tips has a good antipyretic effect in the treatment of fever caused by COVID-19,which can accelerate the antipyretic time,improve the antipyretic efficiency,and reduce the level of inflammatory factors.

The author studied the imaging features of meningeal vascular neurosyphilis，and provided guidance for the differential diagnosis of cerebral infarction. Methods Patients with meningeal vascular syphilis underwent head MRI plain scan + enhancement，PWI，MRA and SWI. The four parameters of PWI on the side of the lesion were compared with those on the contralateral side of the lesion. Results A total of 7 patients with neurosyphilis underwent head MRI examination，and a total of 9 responsible lesions were found. They are listed as follows，two pontine lesions，one radiative coronary lesion，one thalamic lesion，one occipital lobe lesion，two parietal lobe lesions，one insular lobe lesion，and one frontal lobe lesion. The edge of the lesion in a radiating crown is enhanced. Through MRA examination，6 patients were found to have vascular stenosis. PWI examination of patients with neurosyphilis found that compared with the contralateral side，the rCBV value［（72.47±46.51）vs.（130.68±38.92）］of the responsible lesion area decreased，t=4.172，P= 0.002；and the rCBF value［（111.10±37.89） vs.（153.43±50.81）］also decreased，t=2.804，P=0.025.Conclusion The PWI manifestations of intracranial lesions in patients with neurosyphilis may have different imaging features from cerebral infarction.