Objective To explore the impact of gratitude on interpersonal disturbance in college students and provide positive energy into the establishment of harmonious campus interpersonal relationship.Methods A total of 530 college students at 5 uni-versities in Guangdong province were surveyed by gratitude questionnaires and comprehensive diagnosis scale of interpersonal rela-tions.Results (1)The rate of interpersonal disturbance in college students was 46.4%.(2)Gratitude interacted with genders and grades(P <0.05 ).The levels of gratitude in male freshmen,sophomores,and seniors were remarkably higher than those in male juniors(P <0.01),and female juniors had a higher level of gratitude than their male counterparts remarkably(P <0.01).Scores of male students were significantly higher than those in female students in interpersonal communication,way of treating people,oppo-site-gender interaction and the total scores of interpersonal disturbance(P <0.01 ).Besides,juniors had a remarkably higher score than freshmen and seniors in the factor of social association and friend making (P <0.05 ).(3)There was a significantly negative correlation between the level of gratitude in college students and the total scores of interpersonal disturbance as well as the four fac-tors of interpersonal communication,social association and friend making,way of treating people,and opposite-gender interaction (P <0.01).Subjects with different levels of gratitude showed marked variation in the total scores of interpersonal disturbance and all its factors(P <0.01).Gratitude displayed a significantly negative predictive effect on the total scores of interpersonal disturbance and all its factors(P <0.01).Conclusion Close relation existed between gratitude of college students and their interpersonal dis-turbance,and gratitude could be used to effectively predict college students′interpersonal disturbance.

Objective To explore the association of CD22 gene T＞A locus (SNPrs2267574) with the development of systemic lupus erythematosus (SLE) and SLE phenotypes in Southern Chinese Han people.Methods Two hundreds fifteen cases and 216 normal controls were enrolled with the aim of case-control design,and the genotype was determined by PCR-RFLP.We calculated X2 and ORs for association study.Results In CD22 gene T＞A locus,there was significant difference of genotypes distribution between cases and controls (X2=6.086,P＜0.05).The frequency of AT genotype was higher in cases than in controls (OR=1.68,95%CI:1.08～2.60,P=0.021 ),and A allele had a higher proportion in cases (OR=1.58,95%CI:1.09～2.29,P=0.015).Meanwhile,the frequency of A allele in patients with positive anti-SSA was higher than in patients with negative anti-SSA (OR=3.69,95%CI:2.08～6.52,P＜0.01 ).Conclusion In Southern Chinese Han population,CD22 gene T＞A locus is associated with the development of SLE and the A allele has positive association with anti-SSA.