Objective To evaluate the value of serum CA 19-9 levels in predicting resectability of pancreatic cancer. Methods Serum CA 19-9 levels of 52 patients with pancreatic cancer who were possible to be curatively resected according to the imaging were determined; the gold standard was respectability. An receiver operating characteristic (ROC) curve was constructed for the CA 19-9 levels; the point that lies closest to the upper left-hand comer of the graph is chosen as the cut-off point, the sensitivity, specificity,positive and negative predictive values were calculated. Results There were 29 (55.8%) resectable and 23 (44.2%) inoperable cases of pancreatic cancers. The CA19-9 level in resectable patients was (159.6±170.9)U/ml, and it was (944.4 ±773.4) U/ml in inoperable cases. The area under the ROC curve was 0. 918 ( ＞ 0.9, P ＜ 0.01 ), 95% confidence interval were 0.843 ～ 0.992. The CA19-9 level was (353.2) U/ml according to the cut-off point, the sensitivity and specificity was 93.1% and 78.3%, respectively; positive and negative predictive values was 84. 4% and 90. 0% , respectively. Conclusions Preoperative serum CA19-9 level may be a useful marker for further evaluating the respectability of pancreatic cancer who are possible to be resected according to the imaging studies.

Objective To establish the differentiation standard of stasis-heat TCM syndrome. Methods With Delphi statistics method, the expert questionnaire of diagnosis and treatment on stasis-heat TCM syndrome was worked out on the basis of literature research, and sent to more than 30 experts in two rounds. The investigation results and the suggestion of experts were analyzed. Results The recede effective questionnaire amount was 32 and 31 respectively in two rounds. The positive coefficient was 94% and 97% respectively. According to the investigation results, the standard of syndrome differentiation of stasis-heat syndrome was made. The suggestions from experts were about the same. The clinical manifestations of stasis-heat syndrome includes fever, bleeding, pain, abnormal mind, specific manifestations on skin, complexion, tongue and pulse, etc. The main points of syndrome differentiation are deep red tongue, red and blue purple choroides, crimson face, florid bleeding or bleeding with dark purple blood clots, and red purple tongue. Conclusion Differentiation standard of stasis-heat TCM syndrome formulated by Delphi statistics method conform to the thinking of TCM syndrome differentiation. The researchresults gave prominence to the pathogenesis characteristics of stasis-heat TCM syndrome and played a part in gathering expert consensus.

Objective: To investigate the effects of recombinant human erythropoietin (rhEPO) on the expression of heme oxygenase-1(HO-1) mRNA after renal ischemia/reperfusion (IR) in mice. Methods: Ninety male C57BL/6 mice were randomly divided into three groups, namely, the sham operation group (n = 30), renal IR group (n = 30), and rhEPO treatment group (n=30). Mice were sacrificed at 1, 2, 3, 6, 24, and 48 h after renal reperfusion, and the renal function was evaluated by determining blood creatinine. Histological damages were observed using a semi-quantitative histomorphological scoring system from 0 to 4. Cell apoptosis was analyzed by TUNEL staining in each group. HO-1 and IL-6 mRNA expression was examined by real-time PCR. Results: Compared with renal IR group, the expression of HO-1 mRNA was significantly higher in rhEPO treatment group at 3 , 6, and 24 h after reperfusion(P<0.05). The expression of IL-6 mRNA was significantly lower in the rhEPO treatment group at 6, 24, and 48 h after reperfusion(P<0.05). Serum creatinine level in the rhEPO treatment group was significantly lower than that in the renal IR group at 24 h after reperfusion(P<0.05). Compared with the renal IR group, renal histology injury was greatly attenuated by rhEPO in rhEPO treatment group. TUNEL staining analysis indicated that the apoptotic cells in the IR group were significantly more than those in the sham operation group(P<0.05), and those in the rhEPO treatment group was significantly less than those in the IR group(P<0.05). Conclusion: rhEPO can attenuate renal ischemia/reperfusion injury in mice, probably through promoting the renal expression of HO-1 mRNA.

Objective: To investigate the distribution of neural cholinesterase and elastic and collagen fibers in rat pancreatic tissues. Methods: Rats were decapitated and the pancreatic tissues were harvested, frozen and made into 8 μm serial sections. A combined-staining method (K-R-VB-P-PA method, a combination of Karnovsky-Roots and Victoria blue-Ponceau-Picric acid) was used for staining and the distribution of neural cholinesterase and elastic and collagen fibers was observed. Results: The results showed that the neural cholinesterase was brown, the elastic fibers were cyan, the collagen fibers were light red, and the smooth muscle was yellow in the pancreatic acinar, islet of Langerhans and blood vessels. Conclusion: K-R-VB-P-PA combined staining method can demonstrate the distribution of neural cholinesterase, elastic and collagen fibers and smooth muscle fibers in the pancreatic tissues synchronously.

Objective: To develop a compound staining method showing collagenic, elastic fibers and melanocyte in skin tissues. Methods: A staining meth od combining Masson Fontana silver nitrate, Ponceau S, Picric acid and Victoria blue (MFSN-P-PA-VB) was used in the present animal skin experimental. Results: The melanin granule was blac k in the skin melanocyte, collagenic fibers were red, the red blood cells at hemorrhagic focus were yellow, and the elastic fibers were green by this MFSN-P-PA-VB staining method. Conclusion: This compound staining method has multicol or and fine contrast, and can better show melanins, the red blood cells at hemorrhagic focus, and collagenic and elastic fibers.

Lung cancer, a malignant cancer with highest death rate, severely threats the people's health. 80% lung carcinomas are non-small cell lung cancer (NSCLC). Recent studies have found that estrogen system has close relationship with the biological behaviors of NSCLC. Meanwhile, the level of estrogen influences the progression of disease and the prognosis of lung cancer patients. As a result, estrogen pathway has become a hot target in NSCLC treatment. This paper reviews the recearch advances of estrogen system in NSCLC treatment.

Adult ; Aged ; Female ; Herbicides ; poisoning ; Humans ; Male ; Middle Aged ; Paraquat ; poisoning ; Poisoning ; therapy ; Young Adult

A platinum-based doublet with a third-generation agent represents the standard first-line treatment for advanced non-small cell lung cancer patients with good performance status (PS). Traditional chemotherapy provides response rates of 20 %-40 % and a median survival of 8-10 months. In an attempt to improve its outcome, alternative schedules have been proposed, namely sequential, alternating, and maintenance therapy. Sequential chemotherapy with a platinum-based doublet followed by a single agent is feasible in patients with good PS; The use of sequential single agents is an option for elderly and frail patients unsuitable for a platinum-based combination. Based on trials published so far, it is unlikely that an alternating chemotherapy strategy will be proved superior to standard chemotherapy in patients with good PS.Consolidation chemotherapy may provide additional benefit for patients achieving disease control after standard first-line chemotherapy.

Objective To evaluate the epidemic status of main non-communicable chronic diseases among the residents of Jingan district in Shanghai.Methods Multistage cluster sampling was adopted.960 residents were investigated with questionnaire and physical examination.Results The prevalence rates of Hypertension,diabetes mellitus,Cerebral vessels and Heart-blood were 25.6%,5.8%,3.1%and 5.7%,respectively.The multivarate logistic regression analysis showed that the related risk factors to four non-communicable chronic diseases included family history,the OR(95%CI)1.6(1.2～2.3),6.9 (3.5～13.6),4.5(2.0～10.0),2.2(1.2～4.0)separately.Conclusion Hypertension,diabetes are the main non-communicable disease hazarding the public health.The government and professional institutes should raise the attention on this serious problem and finance more as well as supplying policy support.

Objective:To observe the effect of Busheng Yiqi Huoxue Capsule on the lipid peroxide, lipofuscin, lipid of aged rats and on the lipid, platelet aggregation and prostaglandin of the experimental hyperlipidemic rats. Methods: Adopting the aged rats and dividing randomly into groups, the indicators of MDA. lipofuscin, lipid were determined; Adopting the hyperlipidemic rats fed by high lipid diet and dividing randomly into groups, the indicators of lipid, platelet aggregation, 6 tone PGF 1? and TXB 2 were determined. Results: Busheng Yiqi Huoxue Capsule can reduce the level of lipid peroxide in the heart, brain, liver and plasma, the level of lipofuscin in the heart and brain and the level of lipid in the aged rats ( P