1.Clinical Significance of Correlation Factors on Serum PSA Concentration
Chenyang ZHONG ; Ming LIU ; Shuming DENG
Journal of Chinese Physician 2001;0(04):-
0 05). 70 of 138 patients had serum PSA concentration remarkable elevation after prostate biopsy (P
2.Identification of novel B(A)803 C→G allele mutation in Chinese population and induction of severe hemolytic disease of the newborn
Youwan YE ; Zhihui DENG ; Shuming ZHOU ; Qiong YU ; Xuenian YIN ; Qian LI ; Yuqing SU ; Yanlian LIANG
Chinese Journal of Laboratory Medicine 2008;31(1):68-71
Objective To investigate serological blood typing of the ABO locus which contradict to general law of inheritance in parentage,and the underlying reasons for severe hemolytic disease of newborn(HDN).Methods To research the family whose newborn is AB phenotypes,mother is O phenotypes and father is AB phenotypes.The familiy were genotyped by parentage tests, serological tests,PCR-SSP and direct DNA sequencing at exons 6 and 7 of ABO gene.At the salne time,HDN was detected by micro column gel Coombs (MGCT), and the primary fingerposts of the routine blood tests. Biochemical tests were dynamically observed.Results The results of parentage tests showed that three-generation pedigree have parent-child relationship. The red blood cell(RBC)of this AB phenotypes of this family members strongly agglutinated(4+)with diverse monoelonal anti-A and anti-B antibodies,and their serum did not contain anti-A and anti-B antibodies in blood anti-typing.PCR-SSP can not detect their A and B gene,but DNA sequencing at exons6 and 7 of ABO gene revealed that it had the B(A)803C→G mutation.Conclusions The genetm basis of this parentage are B(A)803G blood gene which harbored both A and B difunctionality of glyeosyhransferases.This was the first report that severe HDN resulting from a large number of A and B antigens in RBC of B(A)phenotype of a newborn,which has clinical significance on ABO locus.
3.Training situation of provincial-level healthcare-associated infection train-ing agencies in China
Yahong YANG ; Xun HUANG ; Haojun ZHANG ; Ding LIU ; Huai YANG ; Shuming XIANYU ; Qiuping FAN ; Ling LIN ; Min DENG ; Anhua WU ; Weihong ZHANG ; Weiguang LI ; Yun YANG ; Yao SUO ; Huan YANG ; Xinling HUANG ; Qun LU
Chinese Journal of Infection Control 2016;15(9):659-664
Objective To understand the current situation and existing problems in the training of healthcare-asso-ciated infection(HAI)management,and provide scientific basis for strengthening the management of HAI preven-tion and control system.Methods A questionnaire survey was adopted to investigate situation of training on HAI in 15 provincial-level HAI training agencies in China during the past 30 years,and basic condition of training on HAI management in recent 5 years.Results Among 15 provincial-level training agencies,66.67%(n=10)were respon-sible by HAI management quality control centers,80.00% have already conducted training in each city,53.33%carried out training for 10 to 20 times,33.34% performed training for ≤2 times per year.Of 33 728 trainees in 2011-2015,41.30% were 41-50 years old,61.82% were nursing staff,50.56% had bachelor degree,43.96%were with the intermediate professional title.Most trainers were HAI prevention and control experts in their respec-tive province,accounting for 68.07%,the curriculums were mainly designed on professional course,and only 26.78% were involved in management.Conclusion Professional structure of HAI management personnel is not reasonable,faculty is imbalance,knowledge update is lacking,and HAI training and education system need to be improved further.