OBJECTIVE:To compare the therapeutic effects and cost-effectiveness among 3 therapeutic regimens. METHODS:85 cases with sudden deafness were divided into 3 groups:Group A (n=30) were ascribed to receive buflomedil, Group B (n=28) to receive compound Danshen and Group C (n=27) to receive Herba Erigerontis. The curative effects of the 3 were observed and the cost-effectiveness of which were analyzed. RESULTS:The costs of the 3(A, B and C) were 1 908.20yuan, 1 102.68yuan and 1 825.64yuan, respectively. The effective rates of the 3 were 93.33%, 60.71% and 70.37%, respectively. The cost-effectiveness ratios were 20.45yuan, 18.16yuan and 25.94yuan, respectively. As compared with Group B, the incremental costs for Group A and C were 24.73yuan and 74.84yuan, respectively with every one-unit effectiveness increase. CONCLUSION:Group C is the superior one among the 3 therapeutic regimens.

Objiective:To investigate the relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation,also to investigate the relationship between MMP-2,cardiac function and left atria diameter of patients with atrial fibrillation.Methods:49 patients with persistent atrial fibrillation were included in the atrial fibrillation groups,and 47 patients with sinus rhythm were selected in the control group,the serum concentration of MMP-2 and TIMP-2 were measured with ELISA.The size of left atria diameter were detected with Doppler Ultrasonic cardiogram.Results:(1) The level of MMP-2 in atrial fibrillation group was significantly higher than that in control group(P0.05).(2) The size of left atria diameter in atrial fibrillation group was significant higher than that in the control group(P

The application of evidence-based medicine in bibliotherapy is defined as evidence-based bibliothera-py.After a description of the connotation, role and significance of bibliotherapy, and foreign and domestic studies on it, the problems in domestic bibliotherapy were pointed out with measures put forward for their solution, and the implementation of bibliotherapy was normalized in view of its methodology.

OBJECTIVE:To observe the clinical efficacy of misoprostol in the prevention of postcesarean hemorrhage(PCH).METHODS:344pregnant women with indications of cesarean section were randomly divided into3groups:group A were receive200mg of misoprostol sublingually,and group B to receive oxytocin by IV drop and myometrium injection with group C as control(no any drug was given)right after childbirth.PCH at different time were observed.RESULTS:Compared with group C,both the amounts and the incidences of PCH in group A and B were significantly lower(P

Objective Through oral vaccination activity on polio,the epidemiological and virological surveillance of acute flaccid paralysis (AFP) case finds its way to develop, so that the realization of eradication on polio may be verified.Method Various kinds of immunization activities such as regular basic immunization, booster vaccination, intensified vaccination and mopping-up operation were adopted among children of the right age in the whole province. Zero case report and active surveillance on AFP were carried out to those population under 15 who had had consultation in medical unit above county level. Each reported case or found case was treated by individual case investigation, follow-up study and sample collection. All the samples were virus-isolated ad identified by RD, Hep-2 and L20B cells. Result Since 1991, an AFP case surveillance system has been built up. Up to the end of 2000, a total of 1,749 AFP cases had been reported in hunan province, from which 1,404 cases samples were collected, and another 218 cases samples of contacts were also collected. A sum of 7 polio wild virus strains was examined out. Since July 1993, no wild strain has been found (isolated). Conclusion Hunan Province has successfully intervened in the circus (spread) of polio wild virus, and hence realized the goal of polio eradication.

The left to right shunt rate(F)and the transverse seetional area of ductus arteriosus(A)were calculated by color Doppler flow convergence method in 20 patients with patent ductus arteriosus.The results indicated that the shunt rate(F)was correlated fairly with Qp-Qs,Qp/Qs(measured by pulsed wave Doppler),the pressure gradient(△P)and the diameter of left ventricle(DLV)(r=0.81,0.62,0.69 and 0.53;P＜0.001,0.005,0.001 and 0.01,respectively).The transverse sectional area of ductus arteriosus(A)was also correlated closely with the diameter of ductus arteriosus(Dd)measured directly in two-dimensional view(r=0.81,P＜0.001).The F value of group Qp/Qs≥2:1 was apparently higher than that of group Qp/Qs＜2:1(P＜0.005).The color Doppler flow convergence method can rapidly and exactly evaluate the left to right shunt severity of patent ductus arteriosus.

High frequency key words in papers on MOOC were retrieved from CNKI and Wanfang Data Knowledge Service Platform.A co-words matrix was constructed , which was then transformed into correlation matrix and dis-similarity matrix, respectively.The correlation matrix was analyzed by multidimensional scaling analysis to show the hotspots in domestic MOOC studies on teaching reform, open education, information technology, resource develop-ment, library service innovation and its development trends.

Objective To evaluate the significance of suPAR,SCC-Ag in plasma and HPV16,18 in cervical secretion for monitoring pathogenetic condition and prognosis in patients with cervical cancer.Methods 206 cervical cancer patients blood and cervical secretion were collected.Plasma level of suPAR and SCC-Ag were measured by enzyme linked immunosorbent assay (ELISA) in health women and patients with cervical cancer.The expression of HPV16,18 of cervical secretion in control group and patients with cervical cancer were detected by fluorescence quantitative PCR.The correlations of the three indexes were analyzed.Results The plasma level of suPAR and SCC-Ag,the expression of HPV16,18 of cervical secretion in cervical cancer patients were obviously higher than those in health controls with statistical significance ((1.072 5±0.305 2) ng/ml vs (0.501 7±0.179 3) ng/ml,(0.980 6±0.162 7) μg/ml vs (0.261 4± 0.006 3) μg/ml and 53.89 ％ (90/167),46.15 ％ (18/39) vs 6.67 ％ (4/60),P ＜ 0.05).There was a positive correlation between plasma suPAR level and SCC-Ag level in invasive carcinoma of cervix patients (r =0.564,P ＜ 0.05).The plasma level of suPAR between in HPV16,18 positive group and in HPV16,18 negative group did not show difference (P ＞ 0.05).Conclusions In invasive carcinoma of cervix patients,there is a positive correlation between plasma suPAR level and SCC-Ag level.But it's not yet to conclude that plasma suPAR level of cervix invasive carcinoma patients is related to infection of HPV16,18.

Primary aldosteronism(PA) is one of the most common causes of secondary hypertension,plasma aldosterone concentration(PAC)/plasma renin activity (PRA) ratio is widely used in clinical practice.However,PRA reflects the level of plasma renin indirectly.In recent years,plasma renin concentration (PRC) has been measured by automatic chemiluminescence immunoassay,which is more stable,convenient and with less confounding factors than conventional renin activity.This review briefly introduces methods of examining PRA,PRC and PAC,and compares the value of PAC/PRC ratio with PAC/PRA ratio in PA detection.

To apply more precise upper airway modeling and computer fluid dynamic technology, and simulate the upper airways of the fluid velocity, flow field distribution and pressure changes on 1 case of OSAHS patients before and after surgery. At home and abroad, computer fluid dynamic has been applied to research on human airway and predict curative effect before and after operation, but the study of the whole upper airway fluid physics parameter is less within normal people and sick people, more the lack of large sample research. The application of this technology can lay the foundation to establish normal people and sick people upper airways database, formulate normative operation and research process, the quantitative domestic normal population and pathological airway blocking criteria of each plane, develop a handling the precision of simulation software and the curative effect of surgical or medical treatment evaluation system, and open up the new train of thought of OSAHS patients diagnosis and treatment.
Airway Obstruction ; Humans ; Hydrodynamics ; Pharynx ; Pressure ; Sleep Apnea, Obstructive ; diagnosis ; therapy ; Software ; Surgery, Computer-Assisted ; Tomography, X-Ray Computed