1.Impacts of characteristic personal behaviors on physicians' drug prescription behaviors based on KABP model
Heng WANG ; Zhanchun FENG ; Shuman XU
Chinese Journal of Hospital Administration 2012;28(7):544-547
Within the KABP model as a framework,the authors studied these behaviors at the following three levels,namely knowledge and learning,beliefs and attitude,and behavior.Such aspects as the education background and training,drug expertise,drug infonmation sources,personal experience and habits,attitudes,needs of physicians and patients',socio-demographic characteristics were discussed among others to probe into how physicians' personal behavior affects their prescription behavior.Recommendations raised include education and training,provision of correct drug information,greater publicity,better compensation mechanism of public hospitals,strengthened supervision,establishment of the system of prescription audit,etc.
2.Platelet α and β secretase activities in mild cognitive impairment and Alzheimer's disease
Hongqi YANG ; Shuman FENG ; Qiuhuan JIANG ; Jianjun MA
Chinese Journal of Neurology 2012;(11):783-786
Objective To investigate platelet α and β secretase activities and the amounts of platelet soluble fragment of APP (sAPPα) produced by α-secretase in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).Methods The neurological functions of 48 nondemented patients,42 MCI and 40 AD patients were evaluated by neuropsychological examinations.The platelet α and β secretase activities and sAPPα production in each group were measured by fluorescence and Western blotting analysis respectively.Results The α secretase activities in non-demented,MCI and AD group were 100.0% ± 10.6%,78.2% ± 9.4% and 61.8% ± 7.2% respectively.As compared with nondemented group,the α secretase activities in MCI and AD group were decreased (F =22.935,P =0.001).The α secretase activity in AD group was significantly lower than MCI group.The β secretase activities in non-demented,MCI and AD group were 100.0% ± 11.2%,145.8% ± 12.7% and 189.8% ± 14.2%respectively.The β secretase activities in MCI and AD group were significantly higher than that in nondemented group (F =16.368,P =0.001).The β secretase activity in AD group was significantly decreased as compared with MCI group.The sAPPα amounts in MCI group and AD group were all decreased as compared with that in control group; the sAPPo amount in AD patients was significantly decreased as compared with that in MCI group.Conclusions The platelet α secretase activity and its production sAPPα in MCI and AD patients are decreased,while β secretase activity is increased,as compared with that in control group; the altered α and β secretase activities may participate in the pathogenesis of MCI and AD patients and may have diagnostic potential for them.
3.Ten-year trends of mortality from cerebrovascular diseases in two resident areas in Henan
Shuman FENG ; Bing WANG ; Fang ZHANG ; Junxi ZHANG ; Shuzheng LIU ; Peiliang QUAN ; Jianbang LU ; Jun XU ; Xibin SUN
Chinese Journal of General Practitioners 2011;10(9):666-668
The cluster sampling method was used and a retrospective survey on mortality trends of cerebrovascular diseases from 1989 to 2008 was conducted among residents from Erqi District in Zhengzhou city and Xigong District in Luoyang city. The average mortality rate of cerebrovascular diseases in these two districts was 69. 5/100 000 in 1989 to 2008. The standardized mortality rate for men was 118. 67/100 000 in 1989 to 1993, and dropped to 44. 23/100 000 in 2004 to 2008. The standardized mortality rate for women was 68.21/100 000 in 1989 to 1993, and dropped to 30. 2/100 000 in 2004 to 2008. The declining trends of cerebrovascular disease mortality rates might be related to early diagnosis and early treatment of the disease, and the extensive health education and prevention programs.