Objective To study the effects and mechanism of berberine in combination with magnolol and honokiol on the formation of THP-1 macrophage-derived foam cells. Methods THP-1 macrophages were induced into foam cells by ox-LDL, and intracellular cholesterol in foam cells was determined by HPLC-MS; the concentration of tumor necrosis factor-α in the supernate of THP-1 macrophages was tested by ELISA and cell-surface CD36 level was assessed byflow cytometry. Results Combined treatment of berberine, magnolol and honokiol significantly reduced cholesterol con-tent in foam cells, also inhibited expression of tumor necrosis factor-α and CD36 in THP-1 macrophage. Conclusion Co-administration of berberine, magnolol and honokiol can inhibit the formation of foam cells probably through, down-regulating the level of tumor necrosis factor-α and CD36.

Objective To detect serum CA125 and VEGF in patients of non-Hodgkin lymophoma (NHL) involved in bone marrow and analyse prognostic criteria for NHL. Methods The clinical data of 97 patient were chosen as research objects. They were all first-visit patients. Bone marrow infiltrated with lymphoma cell leukemia of 50 patients were identified by bone marrow aspiration or bone marrow biopsy 46 cases of normal bone marrow were used as controls. The serum CA125 and VEGF were detected by ELISA before treatment. Results Among 97 cases of non-Hodgkin disease, there were 50 cases of bone marrow infiltrated lymphoma cells with a incidence rate of 51.5 %. CA125 and VEGF level in the patients whose bone marrow or lymphoma cell leukemia existed NHL cells was much higher than that of NHL with negative bone marrow infutration (P <0.05). Conclusion CA125 and VEGF can be concluded clinical markers which decide bone marrow or lymphoma cell leukem of the NHL patients whether existed NHL cells or not.

Objective To discuss the effectiveness of standardized management of hypertension and its significance of economics.Methods Taking prospective,randomized and controlled trial design to screen hypertension in four communities of Changping Town.The patients in the four communities were randomly divided into an intervention group and a control group.The intervention group was taken the standardized management and the control group was taken conventional management.Results The treatment rate and control rate of the intervention group was higher than the control group.Necessary inputs of per capita administration costs for every 1％ increase of treatment or control rate in the intervention group were less than the control groups by 1.08 and 1.36 Yuan respectively.The per capita administrative costs of intervention group were higher than control group,while the per capita comprehensive costs of intervention group were lower than control group.Compared with the control group,every 1 Yuan of per capita administrative costs increases,the comprehensive costs would be reduced 7.58 Yuan in the intervention group.Conclusion Standardized management of hypertension in community can significantly improve the prevention and treatment effects.Moreover,it has good cost-effective value and saving social resources.

Asian Continental Ancestry Group ; Humans ; Leukemia ; Lymphoma, Large B-Cell, Diffuse