Objective:To observe the chronological and spatial expressions of integrin ?2,?3 and ?5 which were the receptor of extracellular matrix(ECM) in the developing mouse kidney and investigate the correlation of integrin ?2,?3 and ?5 with kidney development.Methods:The expressions of integrin ?2,?3 and ?5 were examined by immunohistochemistry and stereological method.Results:The expressions of ?2,?3 and ?5 were observed from the kidney of E12d.The expression of integrin ?2 was little in the glomeruli,but obviously in renal tubules and collecting ducts,while the expression of intergrin ?3 was obviously in glomeruli.The expressions of integrin ?2,?3 and ?5 were increased gradually with kidney development by stereological analyses.Conclusion:It is suggested that integrin ?2,?3 and ?5 might play the important role in the kidney development of mouse.

OBJECTIVE:To study the pharmaceutical human resources management and new management modes.METHO_DS:Survey and analysis were based on the relevent literature and combined with the actual situations of human resources man_agement of pharmaceutical enterprises in China.RESULTS & CONCLUSION:Only by raising the level of human resources management and practicing new management modes,will the pharmaceutical enterprises get sustained benefit of the company and society.

OBJECTIVE:To provide a human resources management reference model of pharmaceutical enterprises in new situation in China METHODS:Consulting relevant literature and data of investigation,we analysed the changes and development of human resources management in pharmaceutical enterprises since the founding of our republic RESULTS & CONCLUSION:We put forward an idea of modern management model Only when human resources management model conforming to the reality in China is adopted can pharmaceutical enterprises subsist and develop

The fresh cadavers were injected with A. B. S into the popliteal arteries. We have studied the micro-vascular structure of this skin area under scanning electron microscope. There are 5 layers of the vascular network in this skin area. They were formed by the small branches coming from either the direct or indirect cutaneous arteries. The 5 layers are as follows: The capillary network of the papillary layer. The vascular network of the subpapillary layer. The deep dermal network. The network in the subcutaneous tissue. The network in the deep fascia tissue. It is clear that each layer of the vascular network has it's -own special character.

The vascular morphological character of the microcirculation in the nail bed of the toe have been studied with the scanning electron microscope. Three types of vascular network were identified: 1) The blood vessels at the proximal two fifth of the nail bed were parallelly arranged. 2) At the middle two fifths of the nail bed, the blood vessels interwoved with each other and formed the polygonal vascular networks. 3) At the distal one fifth of the nail bed there were only a few vascular loops running in a slanting position. These loops were connected with the vascular network from the papillary layer of the skin of the toe.

Green tea is a drink made from the steamed and dried leaves of the Camellia sinensis plants.Green tea contains a number of bioactive chemicals,including polyphenols that exert anticancer and antioxidant properties.Many studied have shown that green tea polyphenols have neuroprotective effect in cerebral ischemia through the mechanisms of antioxidant,antiapoptosis,and reducing brain edema.

Objective To observe the effect of Lipo PGE1 and Mecobalamine and Ginkgo-dipyidamolun in the treatment of dia-betic peripheral neuropathy. Methods 60 Patients with diabetic peripheral neuropathy were divided randomly into two groups; the control group (30 cases) and the treatment group (30 cases). The patients of the treatment group were given with Lipo PGE1 100 ?g dissolved in 0.9% normal saline solution 100ml once a day intravenously, and given mecobalamine 500 ?g once a day intramuscular, and given Ginko-dipyidamolum injection 20ml dissolved in 0.9% normal saline solution 250ml once a day intravenously; and in the control group were only given with mecobalamine 500?g once a day intramuscular. Nerve conduction velocity (MNCV and SNCV) in two groups of patients was observed after 14 days treatment. Results After treatment for 14 days, the subjective symptoms and signs were significantly improved with a total effective rate of 86.7% in the treatment group versus 56.7% in the control group. Compared with the control group, the total effective rates of treatment group was significantly higher (P

Circulating tumor cells (CTCs) detections have unique advantages in the real-time personalized medicine of patients with tumors.The rarity and heterogeneity of CTCs in peripheral blood pose great technical challenge for CTCs researches.Most of technologies for detecting CTCs have been developed to enrich CTCs by virtue of physical properties or specific biological features of the cells at first,then genotype or phenotype analysis are performed to count or characterize CTCs.Advances in molecular analysis of single cells enable CTCs detections to provide more accurate and comprehensive information.Biological processes during CTCs invasion and metastasis such as epithelial-mesenchymal transition and clustering should to be considered seriously to promote the clinical applications of CTCs detection.

Objective To investigate the relationship of vascular endothelial growth factor(VEGF)with the invasion and metastasis of non-Hodgkin lymphoma.Methods The levels of serum VEGF was measured by enzyme linked-immunoadsorbent assay(ELISA).Comparing the parameters between NHL group and the control group.Compared the parameters with different groups divided by clinical stage,the effect of the treatment,the level of plasma LDH and effect of treatment.Analyzed the correlation of the levels of serum VEGF and plasma LDH in patients of NHL.Results The levels of serum VEGF are remarkablely higher in patients than that in the control group(P＜0.05).The levels of serum VEGF in the group of Ⅲ,Ⅳ clinical stage are higher than that in the group of Ⅰ,Ⅱ clinical stage,but no significant difference(P＞0.05)were observed.The level of serum VEGF is higher in the group of none CR than the group of CR(P＜0.05).The level of serum VEGF is higher in the group of non-normal level of plasma LDH than group of normal LDH level(P＜0.05).The levels of VEGF and LDH are significantly correlated each other(P＜0.01).Conclusion The angiogenesis are important for tumor metastasis in patients of NHL.The serum VEGF can be used as prognosis parameters in patients with NHL.

Objective It has been shown that strong acute stress or long-term chronic stress significantly affects learning and memory. The aim of this study was to investigate the effects of chronic pain on learning and memory and morphological structure of hippocampus in neonatal rats.Methods Sixty SD rats aged 7 days were randomly divided into two groups : (A) chronic pain group ( n = 30) in which 0.5% formalin 0.1 ml was injected subcutaneously into plantar region of hind paw every day for two weeks and (B) control group (n = 30) in which the plantar region of hind paw was touched with cotton-tipped swab every day for 2 weeks instead of subcutaneous injection of formalin. Morris water maze performance was used to test learning and memory. The number of granule neurons in dentate gyrus and pyramidal neurons in CA3 were counted. Results The mean latency period in the Morris water maze intelligence test was significantly longer in chronic pain group than that in control group ( P