1.Impact of uric acid on peripheral blood glucose tested by portable blood glucose meter
Ying LIU ; Pengxia GAO ; Shujun LV ; Lei SHEN
Chongqing Medicine 2015;(15):2068-2069
Objective To investigate the impact of uric acid on peripheral blood glucose measured by the portable blood glu‐cose meter .Methods A total of 60 inpatients with 2 diabetic mellitus(T2DM ) complicating hyperuricemia were chosen as the re‐search group and contemporaneous 60 cases of T2DM without complicating hyperuricemia as the control group .Blood glucose in both groups was measured by the portable blood glucose meter ,meanwhile plasma glucose and serum uric acid were assessed by the biochemical analyzer in order to explore the impact of uric acid on peripheral blood glucose .Results (1)The difference between pe‐ripheral blood glucose and venous blood glucose was correlated with serum uric acid .(2)There was statistically significant differ‐ence in the blood glucose between the two groups .(3 ) The bias of blood glucose value were within the acceptable range . Conclusion Serum uric acid has certain influence on the peripheral blood glucose ,but which is within the acceptable range .The de‐tected blood glucose value of the portable blood glucose meter can be trusted .
2. Clinical value of genetic polymorphism analysis of hypertension drugs for individualized treatment of hypertension patients in the southern Anhui region
Shujun WAN ; Mengying ZHANG ; Min ZHONG ; Xiaolong ZHU ; Yingying ZHANG ; Kun LV ; Shujun WAN ; Mengying ZHANG ; Min ZHONG ; Xiaolong ZHU ; Yingying ZHANG ; Kun LV ; Qilei CHEN
Chinese Journal of Clinical Pharmacology and Therapeutics 2024;29(1):68-75
AIM: To analyze the distribution frequency of gene polymorphisms of β receptor blockers, angiotensin receptor antagonists, angiotensin converting enzyme inhibitors, calcium antagonists, and diuretics in hypertensive patients from southern Anhui province, and provide a theoretical basis for gene detection of hypertension drugs and personalized medication. METHODS: Drug gene testing information from 839 hospitalized patients with hypertension at Yijishan Hospital of Wannan Medical College from July 2021 to April 2023 were collected, and the distribution frequency of each gene locus were analyzed. RESULTS: The genotype frequencies of ACE (I/D) I/I, I/D, and D/D were 42.1%, 46.0%, and 11.9%, respectively. the genotype frequencies of ADRB1 (1165G>C) G/G, G/C, and C/C were 8.3%, 40.0%, and 51.6%, respectively. The genotype frequencies of AGTR1 (1166A>C) A/A, A/C, and C/C were 90.2%, 9.8%, and 0.0%. The genotype frequencies of CYP2C9*3 (1075A>C) *1/*1, *1/*3, and *3/*3 were 91.3%, 8.7%, and 0.0%, respectively; the genotype frequencies of CYP2D6* 10 (100C > T) *1/*1, *1/*10, and *10/*10 were 25.0%, 36.6%, and 38.4%, respectively. The genotype frequencies of CYP3A5*3 (6986A>G) *1/*1, *1/*3, and *3/*3 were 7.0%, 39.0%, and 54.0%, respectively. The frequencies of NPPA (2238T>C) T/T, T / C, and C / C genotypes were 97.9%, 2.1%, and 0.0%, respectively. In addition, there was a significant difference in the genotype distribution frequency of multiple drug related gene loci in southern Anhui compared to other regions in China (P< 0.05). CONCLUSION: The genotype distribution frequency of hypertensive drug related gene loci had certain bias in southern Anhui, and were significant different from other regions in China, indicating that conducting genetic polymorphism testing of hypertensive drugs had certain guiding significance for the individualized application of hypertensive drugs in southern Anhui.