Objective: To investigate the prevalence of colorectal cancer in Yongjia County, Zhejiang Province from 2020 to 2021, so as to provide insights into colorectal cancer control. Methods: Residents registered in Yongjia County at ages of 50 to 74 years were sampled, and positive populations were screened using Zhejiang Provincial Questionnaires for Assessment of Risk of Colorectal Cancer Screening among High-risk Populations and fecal occult blood test, and those positive for questionnaires or fecal occult blood test served as a positive screening. Residents with a positive screening underwent colonoscopy, and the detection of high-risk lesions (colorectal cancer and pericancer lesions) was analyzed among those positive for questionnaires, fecal occult blood test and screening. Results: Totally 102 504 residents were tested, and 46 138 (45.01%) residents completed questionnaire surveys and fecal occult blood tests. The rate of positive screening was 21.10%, and the rate of positive questionnaire surveys was 7.13%, while the positive rate of fecal occult blood test was 15.16%. The rate of positive screening was significantly higher in men than in women (27.06% vs. 17.14%; (χ2=654.747, P<0.001), and there was an age-specific proportion of positive screening (χ2=418.264, P<0.001), with high prevalence seen in residents at ages of 65 to 69 years (26.43%) and 70 to 74 years (24.98%). Colonoscopy was performed among 2 966 residents, with a compliance rate of 30.47%, and colonoscopy detected 348 residents with high-risk lesions, including 317 cases with pericancer lesions and 31 cases with colorectal cancer, with 11.73% detection of high-risk lesions and 1.05% detection of colorectal cancer. The prevalence of high-risk lesions was significantly higher in men with positive screening than in women with positive screening (15.77% vs. 7.59%; χ2=47.915, P<0.001), and there was a significant difference in the detection of high-risk lesions among residents with positive screening at different age groups (χ2=25.909, P<0.001), with a high detection in residents at ages of 65 to 69 years (14.32%) and 70 to 74 years (15.49%). Conclusions The prevalence of high-risk lesions of colorectal cancer is 11.73% among residents living in Yongjia County at ages of 50 to 74 years, and men and the elderly at ages of 65 years and older are high-risk populations for colorectal cancer. Improving the awareness of colorectal cancer prevention knowledge and the compliance of colorectal cancer screening is recommended.

Objective To compare the baroreflex sensitivity (BRS) when controlled hypotension was performed with sevoflurane versus isoflurane in the pediatric patients.Methods Sixty male American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients,aged 3-16 yr,with body mass index of 20-28 kg/m2,scheduled for elective scoliosis surgery under general anesthesia,were randomly divided into 2 groups (n=30 each) using a random number table:sevoflurane-induced hypotension group (group Sev) and isoflurane-induced hypotension group (group Iso).Anesthesia was induced with midazolam,sufentanil and propofol.Endotracheal intubation was facilitated with rocuronium.Anesthesia was maintained with closed-circuit low flow anesthesia with either sevoflurane or isoflurane,maintaining mean arterial pressure at 55-65 mmHg and bispectral index values at 40-60 during surgery.Cardiovascular BRS was measured before induction of anesthesia (T0),immediately after intubation (T1),immediately after the end-tidal inhalational anesthetic concentration reached 1 minimal alveolar concentration (T2),and at 10,20 and 30 min after target hypotension (mean arterial pressure 55-65 mmHg) was achieved (T3-5).Results There was no significant difference in BRS at T0-2 between the two groups (P＞0.05).Compared with the value at To,the BRS was significantly decreased at the other time points in the two groups (P＜0.05).Compared with the value at T1,the BRS was significantly increased at T2,and decreased at T3-5 in the two groups (P＜0.05).The BRS was significantly lower at T3-5 than at T2 in the two groups (P＜0.05).The BRS was significantly lower at T3-5 in group Sev than in group Iso in the two groups (P＜0.05).Conclusion Sevoflurane produces better efficacy than isoflurane when used for controlled hypotension in the pediatric patients.

Objective To investigate a poisoning caused by wild mushrooms and to identify the toxin in these mushrooms.Methods Epidemiological investigation,blood test and mushroom toxin were analyzed.Results This incident was taken place in one family,and all family members were dead.Multiple organ damage was observed in all patients;amatoxins and virotoxins were detected in both mushrooms and the soup,but were not detected in blood samples because of dialysis.Conclusion The incident was caused by wild mushrooms and public education shoud be strenthened to urge people to avoid eating wild mushrooms and go to the hospital immediately if poisoning takes place.

OBJECTIVETo develop the preparation method of licorice juice as a processing excipient and to determine the proper proportion of licorice juice and fructus evodiae during process.

METHODNine experiments were carried out through L9 (3(4)) orthogonal design. The wetting results were compared by using different proportion of licorice juice and fructus evodiae.

RESULTThe optimal preparation process was as follows: the licorice roots were cutted into slices and 12 times of water was added. Then they were decocted for 1 h. The second and third decoction were also carried out by 12 times of water and 1 h. The proper proportion of licorice juice and fructus evodiae was 1:1.

CONCLUSIONThe preparation process is scientific and suitable to prepare the processing excipient.

Chemistry, Pharmaceutical ; methods ; Drugs, Chinese Herbal ; chemistry ; Evodia ; chemistry ; Excipients ; chemistry ; Glycyrrhiza ; chemistry

Objective:To explore the short-term and long-term prognostic outcomes of anatomical liver resection(AR)for patients with perihilar cholangio-carcinoma. Methods:This is a retrospective study.All data were obtained from 4 centers,including The First Affiliated Hospital of Army Medical University,Eastern Hepatobiliary Hospital of Naval Medical University,Sichuan Provincial People's Hospital and Affiliated Hospital of Qinghai University,of a multi-center database.A total of 305 consecutive perihilar cholangiocarcinoma patients receiving radical resection between January 2013 and June 2021 were included in this study.According to the method of liver resection,all patients were divided into the AR group(n=205)and the non-anatomical liver resection(NAR)group(n=100).The baseline characteristics,short-term prognosis and long-term prognosis of the 2 groups were compared. Results:The perioperative transfusion rate and the 30-day complication rate were significantly lower in the AR group than those in the NAR group(P＜0.05).There was no statistically significant difference in the survival rates between the AR and the NAR groups(P＞0.05). Conclusion:The 2 hepatic resection modalities had no obvious effect on the long-term prognosis of perihilar cholangiocarcinoma patients after radical resection,but choosing AR tends to achieve a better short-term prognosis and is worth promoting in clinical practice.