Objective To explore the potential role of apolipoprotein A5 (ApoA5) on the hypertriglyceridemia (HTG)-lowering effects of statin. Methods Twenty-four Sprague-Dawley rats were assigned to 3 groups:(1)control group, with no special treatment. (2) HTG group, treated with 10% fructose water for 6 weeks. (3) statin 4 weeks. Body weight, fasting plasma lipids, and the hepatic expressions of ApoA5 and PPARα were determined. In separate in vitro experiments, the effects of atorvastatin on triglyceride (TG) and the expressions of ApoA5 and PPARα in HepG2 cells were tested. Results (1) Plasma TG was higher in HTG group than in controls group, which was significantly reduced in statin group (both P ＜ 0. 05). (2) Rat hepatic ApoA5expression in HTG group was significantly lower than in control group and it was significantly higher in statin group than in HTG group (both P＜0. 05). (3) Similarly, rat PPARα mRNA expression in HTG group was lower than in control group and it was higher in statin group than in HTG group (both P ＜ 0.05). (4) Statin significantly upregulated the expressions of ApoA5 and PPARα and decreased TG in HepG2 cells, which was blocked in the presence of PPARα inhibitor. Conclusion Upregulation of ApoA5 expression contributes to TG lowering effect of statin via PPARα signaling pathway.

Objective To reveal the tendency in clinical nutrition research in chinese journals by bibliometric analysis.Methods Literature was searched in Chinese Biomedical Databases (CBM) of SinoMed.By using Noteexpress software,the year distribution,document cartier classifications,research areas,cited frequency of articles and first author distribution were analyzed.Results The number of Chinese literature on clinical nutrition had increased steadily from 1 paper in 1974 to 1980 papers in 2011.The journals with more clinical nutrition articles are mainly professional journals,accounted for 9.21％.Research in the recent 5 years was mainly focused on the modes and timing of nutrition support.The proportions of studies on parenteral nutrition and enternal nutrition were close.Conclusion Clinical nutrition has became one of the hot research topics in China in recent years,although the appropriate and reasonable use of clinical nutrition remain challenging.