Objective To observe the clinical effect of health education pathway on patients after hip replacement. Methods Patients after artificial hip replacement (200 cases) were divided randomly into the observation group and the control group with 100 cases in each group.The control group adopted general health education methad.The observation group was given health education according to health education pathway.The level of disease-related knowledge and satisfactory degree were compared between the two groups. Results The level of disease-related knowledge and satisfactory degree in the observation group were higher than those of the control group (P < 0.01 ). Conclusions Health education pathway can facilitate level of disease-related knowledge and positive cooperation with treatment and nursing of patients as well as increase satisfactory degree of patients.