1.Simvastatin effect on inhibiting of the production of serum IL-6 and promotion the regeneration of sciatic nerve of rats
Zhi ZHAO ; Hui ZHAO ; Shuhong LU
Orthopedic Journal of China 2006;0(24):-
[Objective]To study the effect of Simvastatin on the regeneration of sciatic nerve of rats and its mechanism of immunoregulation.[Method]Twenty eight female Sprague-Dawley rats were used and the rats experienced the sciatic nerve crush injury.Animals were randomized into: Simvastatin-treated crush injury animals,vehicle-treated crush injury animals and sham-operated animals.Simvastatin(20 mg/kg) was given once a day over a time period of 14 day sby oral gavage via a pharyngeal tube.After surgery,the functional evaluation of nerve recovery,electrophysiologic assessment,histological assessment,serum IL-6 and TNF-? assessment were performed.[Result]The toe spread index of Simvastatin-treated crush injury animals was higher significantly than that of vehicle rats at d5 and d8(P
2.Clinical observation of azithromycin in treatment of mycoplasma pneumonia in 90 children
Xin ZHAO ; Shuhong LI ; Daojian RONG
Chinese Pediatric Emergency Medicine 2008;15(z1):3-4
Objective To evaluate the effect of azithromycin on mycoplasmal pneumonia (MP).Methods We divided 90 MP cases into azithromycin and erythromycin treatment groups. In azithromycinThe pyretolysis time, cough improvement time, the disappearing time and the mean length of hospitalization of azithromycin group were shorter than that of erythrornycin group. The local ache, stomach and intestinal tract adverse reaction, and damage of hepar function were less than these in erythromycin group. ConclusionAzithromycin is an effective and safe drug to MP.
3.Research on the influence of patient safety culture cognition on safety nursing behavior among nurses
Shuhong YANG ; Bin CHEN ; Qiaoyu ZHAO
Chinese Journal of Practical Nursing 2017;33(13):1027-1030
Objective To investigate the status of patient safety culture cognition and safety nursing behavior among nurses and examine the influence of patient safety culture cognition on safety nursing behavior of nurses using structural equation model. Methods A total of 350 clinical nurses were recruited in a hospital in Dalian with multi-stage sampling method. Patient Safety Culture Assessing Scale, Safety Behavior Scale were delivered to the investigation object. Results The mean score of the patients safety culture was 4.09±0.47, which was above average;the total score of nurses′safety nursing behavior was 4.74 ± 0.31, which was at high level; the causality model of patient safety culture cognition and the safety nursing behavior was accepted (path coefficient=0.35,P<0.01). Conclusions Nurses′ patient safety culture cognition has a significant impact on safety nursing behavior. Hospital should cultivate the awareness of the patient safety culture, so as to promote the safety nursing behavior.
4.Practice of problem-based learning in clinical education
Haijing ZHAO ; Xinping ZHANG ; Weidong ZHANG ; Shufang ZHAO ; Shuhong FAN
Chinese Journal of Medical Education Research 2006;0(11):-
Problem-based learning(PBL)plays an improtant role in fostering the ability of problem-solving,creative thinking and active learning of medical undergraduates.Based on the present clinical education resources,how to implement PBL at the largest advantages is the main issue we should concern.
5.Clinical manifestations and endoscopic findings of congenital prepyloric membrane
Fenglin LIU ; Xiaohua XU ; Zhiwei XIA ; Shuhong ZHANG ; Yu ZHAO
Chinese Journal of Digestive Endoscopy 2008;25(4):173-177
Objective To study gastroscopic features and clinical diagnosis of prepyloric mem-brane. Methods Clinical characteristics,gastroscopic manifestation and operational findings of 18 pa-tients,whose prepyloric membrane have been confirmed by operations,were retrospectively reviewed. Results Gastroscopie findings showed that all the 1 8 patients suffered gastric retention and pyloric obstruc-tion to some degree,with 4 cases of esophageal erosion and/or esophageal ulcer,five cases of erosive hemor-rhagic gastritis,one case of ulcer at gastric antrum,gastric comer and pylorus respectively. There were 2 ca-ses of aperture like narrowing in prepyloric region. And there were 9 cases that showed obvious congestion and edema in the prepyloric mucus,with uniform circular mucusal protrusion around the stenosing stoma,and volcano-like depression in the middle,three cases of which showed mucosal membrane standing out to the gastric cavity. The membrane found in the above 11 cases located in pyloric exit or tube,and they under-went membrane excision and py|oroplasty. The other 7 cases showed thick mucosal folds at the distal antrum with radial arrangement. Round or irregular stenosing stoma were observed. These cases proved to be antral membrane,1-3 cm away from the duodenum and pylorus,and underwent simple membrane resection. Conclusion Congenital prepyloric membrane is rare and it likely mis-diagnosed. The onset and the degree of symptoms depend on the diameter of aperture of the membrane. Early endoscopy,in addition to barium contrast,should be performed on those children who have intermittent bilious vomiting,where false-positive radiological findings can be avoided,therefore,to facilitate right diagnosis and appropriate operation.
6.Correlation between Bile Reflux Gastritis and Helicobacter Pylori Infection in Children
Yu ZHAO ; Shuhong ZHANG ; Fenglin LIU ; Juan LI ; Yan LI
Tianjin Medical Journal 2014;(5):485-486
Objective To assess the relationships between bile reflux gastritis (BRG) and Helicobacter pylori infec-tion in children. Methods A total of 258 BRG cases were included in BRG group and 1 749 gastric mucosal inflammation cases without bile reflux were used as control group. Children with BRG were divided into three groups according to the dis-ease classification and they were also sub-divided into three groups according to the bile reflux indexing. The infection rates of Helicobacter pylori were analyzed in different groups. Results Compared to control group (34.02%), the infection rate of Helicobacter pylori was significantly higher in BRG group (46.12%). The infection rates of Helicobacter pylori infection were 40.86%(38/93), 45.53%(56/123) and 59.52%(25/42) in patients with mild, moderate and severe infections. There was no significant difference between them (χ2=4.089, P>0.05). The positive rates of Helicobacter pylori infection were 37.32%(53/142), 53.68%(51/95) and 71.43%(15/21) in children withⅠ,ⅡandⅢreflux indexing, and there was significant differ-ence between them (χ2=12.022,P<0.01). Conclusion Helicobacter pylori infection is one of the causative factors leading to BRG in children. The bile regurgitation increased with the increasing of Helicobacter pylori infection.
7.The Effect of H.Pylori Infection on Gastric Electrical Parameters in Children with Functional Dyspepsia
Yu ZHAO ; Fenglin LIU ; Lina ZHEN ; Shuhong ZHANG ; Juan LI
Tianjin Medical Journal 2014;(1):20-23
Objective To explore the relationship between H.pylori (HP) infection and the functional dyspepsia (FD) by 4-lead electrogastrography (EGG). Methods The data of the gastric electrical activity of 163 children with FD, includ-ing 103 children with HP infection (group A), 60 without HP infection (group B) and 22 healthy controls (group C) were mea-sured by 4-lead EGG, which included normal slow wave percentage (N%), bradygastria percentage (B%), tachygastria per-centage (T%) and motilin uneven rhythm percentage (A%). EGG frequency and power examination included the main fre-quency (DF), the main power (DP) and postprandial/pre-prandial gastric electrical main power ratio (P/R). EGG data was compared between three groups. Results There was significant difference in pre-prandial and postprandial percentage of different slow wave frequency between group A and group B. There were no significant differences in pre-prandial and post-prandial changes of DF and DP between group A and group B. There was no significant difference in the pre-prandial and postprandial percentage change of different slow wave frequencies in 84 HP negative patients. But the significant change was found in pre-prandial and postprandial change of DF, DP and P/R. Conclusion The eradication of HP improved the gas-tric electrical activity and relieved the postprandial symptom in children with functional dyspepsia under HP infection.
8.Changes of sTWEAK and IL-6 levels in patients with acute coronary syndrome and its clinical signifi-cance
Xiuyan WANG ; Xiaohui ZHAO ; Libo WANG ; Jun YANG ; Shuhong LI
Chinese Journal of cardiovascular Rehabilitation Medicine 2016;25(6):584-586
Objective:To explore diagnostic value of soluble tumor necrosis factor - like weak inducer of apoptosis (sTWEAK) and interleukin (IL) -6 concentrations in patients with acute coronary syndrome (ACS) .Methods:A total of 170 ACS patients hospitalized in our hospital from Jan 1st ,2014 to Jun 31st ,2014 were selected as ACS group ,mean‐while ,80 inpatients with stable angina pectoris (SAP) confirmed by coronary angiography (CAG) or coronary CT were se‐lected as SAP group ,and another 80 patients excluded for coronary heart disease (CHD) by CAG were regarded as normal control group .ACS group was further divided into ST elevation myocardial infarction (STEMI) group (n=45) ,non -STEMI (NSTEMI) group (n=52) and unstable angina pectoris (UAP) group (n=73) .Plasma sTWEAK and serum IL‐6 concentrations were compared among all groups .Results:Compared with normal control group and SAP group ,there were significant rise in concentrations of plasma sTWEAK [ (120.32 ± 10.15) ng/L vs .(123.86 ± 15.23) ng/L vs .(140.05 ± 17.51) ng/L] and serum IL‐6 [ (110.34 ± 26.01) pg/ml vs .(112.38 ± 25.74) pg/ml vs .(245.23 ± 68.58) pg/ml] (P<0.01 all) ,but there were no significant difference between normal control group and SAP group , P>0.05. There were no significant difference in plasma sTWEAK and serum IL‐6 concentrations among UAP group ,NSTEMI group and STEMI group , P>0.05 all .Conclusion:Plasma sTWEAK and serum IL‐6 concentrations significantly rise in ACS patients ,which possesses certain diagnostic value for ACS .
9.Effect of NGF on the sperm motility of human in vitro
Kai LIN ; Cuige SHI ; Yongqi ZHAO ; Shuhong LIU ; Ming FAN
International Journal of Laboratory Medicine 2012;33(20):2433-2437
Objective Motility is an important physiological characteristic of a mature sperm.Nerve growth factor(NGF) is a protein essential for the development,maintenance and survival of the peripheral and central nervous systems.NGF and its receptors TrkA and p75 are widely expressed in the testis,accessory reproductive organ,and the epididymal sperms.In the present study,we investigated the role of NGF on human sperm motility.Methods Use 0.1,1 and 10 μmol/L concentrations of NGF,on sperm motility study to investigate the optimal concentration.Use CASA to detect Sperm motility changes every 10 minutes in an hour after 10 μmol/L NGF was added to the semen.Results The parameters of sperm motility increased after NGF incubation had significant difference, in particular,VAP,VSL,VCL,BCF and LIN mean were significantly increased more than 32%.MAD,STR,ALH and WOB mean had no notable difference.Furthermore,NGF promotes the sperm motility in a time- and dose- dependent manner.In addition,the enhancement of NGF on sperm motility was more stronger than those of sperm culture medium.Conclusion Our findings suggest that NGF plays a promoted role in human sperm motility.
10.Cosmetic outcome and curative effect of radiotherapy for early breast cancer after conservative surgery
Changuo MA ; Yuanyuan MA ; Shuhong ZHAO ; Hong WANG
Chinese Journal of Radiation Oncology 2005;0(06):-
93% at 36 months. The local control rate was 100%. The 1- and 3-year survival rates was 100% and 98% , respectively. Conclusions Tangential field radiotherapy for early breast cancer after conservative surgery has a satisfied result in both tumor control and cosmetic outcome, which can definitely improve the life quality of the patients.