Objective To evaluate the effects of 3-dimensional conformal radiation therapy(3DCRT) in form of local control and survival of rectal cancer patients. Methods Forty-two patients with rectal cancer were irradiation by 3DCRT. They first received 40 Gy with larger field, at 1.8-2.0 Gy/f, 1 fraction qd, then followed by a boost of 24-27 Gy with reduced field, at 3.0-4.0 Gy/f, 1 fraction qod, to a total dose of 0,64-67 Gy. Results The 1-,2-,3-year survival rates were 83.3% ,64.3% and 45.2% .The 1-,2-,3-year local recurrence rates were 2.4%,11.9% and 23.9%. Conclusion Three-dimensional conformal radiotherapy is able to prolong the survival and improve the life quality of patients with rectal cancer.

Objective To investigate the effect of antihypertensive therapy on post-stroke depression （PSD） in patients with acute ischemic stroke. Methods A total of 83 patients who were diagnosed with ischemic stroke by computed tomography or brain magnetic resonance imaging within 48 hours after the appearance of symptoms from August 2020 to January 2022 were enrolled in this study， and they were divided into intensive antihypertensive therapy group （intensive group with 41 patients） and standard antihypertensive therapy group （standard group with 42 patients） using a random number table. The goal of the intensive group was to reduce systolic blood pressure to <130 mmHg， and the goal of the standard group was to reduce systolic blood pressure to <140 mmHg. The primary outcome was the incidence rate of PSD during follow-up for 6 months after treatment， which was defined as ≥8 points for Hamilton Rating Scale for Depression-24 Items （HRSD-24）， and secondary outcomes were cognitive tests ［Addenbrooke's Cognitive Examination Revised （ACE-R） and Stroop test］ and activities of daily living （Barthel Index）. The safety outcome was a serious adverse event. Results After 6 months of treatment， compared with the relative changes of systolic blood pressure and diastolic blood pressure in the standard group， the systolic blood pressure and diastolic blood pressure in the intensive group were reduced by 10.6 mmHg and 5.5 mmHg， respectively （P<0.001 and P=0.004）. In addition， the relative change of heart rate during treatment in the intensive group was reduced by 5.0 bmp compared with that in the standard group （P=0.034）. After adjustment for random variables， there was no significant difference in the primary outcome （HRSD score） between the intensive group and the standard group during the treatment period， and HRSD score in the intensive group was reduced by 1.2 （95%CI -0.8 to 1.1， P=0.105）. As for the secondary outcomes， compared with the standard group， the intensive group had significant reductions in ACE-R （P=0.045） and mRS （P=0.036） and significant increases in the scores of accuracy （P=0.027）， interference accuracy （P=0.033）， and animal naming （P=0.008） in Stroop test. There was no significant difference in the overall incidence rate of serious adverse events between the two groups at the end of the trial （χ2=0.597， P=0.440）. Conclusion Intensive antihypertensive therapy has an acceptable safety profile in patients with acute ischemic stroke， but it cannot reduce the risk of PSD.

Tibial dyschondroplasia (TD) cases has not been reported in Tibetan chickens (TBCs), but it is commonly seen in commercial broilers characterized by lameness. The underlying mechanism remains unclear. Hypoxia-inducible factors (HIFs) are important regulators of cellular adaptation to hypoxic conditions. In this study, we investigated the role of HIF-1α,
Anoxia ; Blotting, Western ; Chickens ; Growth Plate ; Osteochondrodysplasias ; Poultry ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; Thiram