1.The association between Fas-670 gene polymorphisms and clinic pathologic index of breast cancer in Qinghai district
Xin HUANG ; Xiujuan WANG ; Liyan JIN ; Shuangyuan ZHANG
Chongqing Medicine 2014;(20):2617-2619
Objective To investigate the correlation between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district .Methods The polymorphisms of Fas-670 gene were detected by polymerase chain reaction-restric-tion fragment length polymorphisms assay (PCR-RFLP) in 232 female breast cancer patients ,χ2 test was applied to assess the asso-ciation between the polymorphisms of Fas-670 gene and breast cancer clinic pathologic index .Results In 232 breast cancer pa-tients ,the frequency of Fas-670 homozygous wild type(AA) ,heterozygous type(AG) ,homozygous mutant type(GG) were 39 .7%(92/232) ,48 .7% (113/232) ,11 .6% (27/232) respectively .It was no statistical significance between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district(P>0 .05) .Conclusion The polymorphisms of Fas-670 gene is not associated with clinic pathologic index of breast cancer in Qinghai district .
2. Meta-analysis of dental implantation success rate in diabetic patients with 6% < glycated hemoglobin level < 8%
Chinese Journal of Tissue Engineering Research 2020;24(16):2620-2624
BACKGROUND: When glycated hemoglobin level is < 6%, the efficacy of dental implantation in diabetic patients is not significantly different from that in non-diabetic patients. However, there are few studies on whether the dental implantation success rate in diabetic patients with 6% < glycated hemoglobin level < 8% is decreased. OBJECTIVE: To evaluate the dental implantation success rate in diabetic patients with 6% < glycated hemoglobin level < 8%. METHODS: A computer-based retrieval of PubMed, Cochrane library, Embase, CNKI, and Wanfang databases was conducted for the articles published before December 2018. Retrospective and case-control studies comparing the dental implantation success rate between diabetic patients with 6% < glycated hemoglobin level < 8% and non-diabetic patients were retrieved. Data extraction and quality evaluation were performed by two researchers. Meta-analysis was carried out. OR and 95%C/ values were used to estimate the success rate of dental implantation in diabetic patients with 6% < glycated hemoglobin level < 8%. RESULTS AND CONCLUSION: (1) Twelve studies were included, involving 2 698 patients and 9 414 implants. (2) Meta-analysis results showed that there was no significant difference in dental implantation success rate between non-diabetic patients and diabetic patients with 6% < glycated hemoglobin level < 8% [OR=1.13, 95%C/ (0.82,1.54). (3) These results suggest that there is no significant difference in dental implantation success rate between diabetic patients with 6% < glycated hemoglobin level < 8% and non-diabetic patients.
3.Changes of the cardiac morphology and size after transcatheter closure of atrial septal defect
Zhaofen ZHENG ; Xiaoqun PU ; Tianlun YANG ; Xiaobin CHEN ; Chuanchang LI ; Daodi PEN ; Long MO ; Lihui ZHANG ; Lamei JIAN ; Jinhua DEN ; Shuangyuan MEN
Journal of Chinese Physician 2000;0(11):-
Objective To evaluate the changes of the right atrium,right ventriculum,left atrium and left ventriculum after transcatheter closure of atrial septal defect(ASD) during a short to mid-term follow-up.Methods The right ventricular end-diastolic anterior-posterior diameter(RVEDD),right atrial long diameter(RADl),right atrial transverse diameter(RADt),left ventricular end-diastolic ante-posterior diameter(LVEDD),left ventricular end-diastolic volume(LVEDV) and left atrial anterior-posterior diameter(LAD) in 36 patients with secundum ASD were measured before ASD closure,after 3 days,3 months and 6 months of ASD closure with transthoracic echocardiography(TTE).Results RVEDD,RADl and RADt were significantly decreased,while LVEDD,LVEDV and LAD significantly increased 3 days after ASD closure.During 3 months follow-up,RVEDD,RADl and RADt continuously became smaller;LVEDD,LVEDV and LAD continuously became larger.At 6 months,RVEDD was significantly smaller and LVEDD,LVEDV were significantly larger than those at 3 months.No remarkable difference of RADl,RADt and LAD was found between 6 months and 3months follow-up.Conclusion Transcatheter closure of ASD not only decreases the preload of right heart and causes right atrium and right ventriculum become smaller,but also improves the geometry of left heart and causes the narrowed left atrium and left ventriculum gradually return to almost normal status.
4.Relationship between famine exposure in early life and type 2 diabetes mellitus in adulthood
Hongyan QI ; Rui DU ; Chunyan HU ; Yi ZHANG ; Jie ZHANG ; Shuangyuan WANG ; Lin LIN ; Mian LI ; Min XU ; Yu XU ; Yuhong CHEN ; Yufang BI ; Weiqing WANG ; Jieli LU
Chinese Journal of Endocrinology and Metabolism 2020;36(11):905-911
Objective:To investigate the correlation between exposure to famine in early life and later risk of type 2 diabetes in adulthood.Methods:A cluster sampling method was used to include 8 868 residents who were lived in the Jiading community of Shanghai during the Great Famine from 1959 to 1962 in China. Subjects were divided into non-exposed group, fetal exposure group, childhood exposure group, and adolescent exposure group. Logistic regression model was used to analyze the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood. Results:Famine exposure during childhood and adolescent both increased the risk of developing type 2 diabetes in adulthood in women. No significant correlation was observed in men. In subjects with less physical activity and lower education level, the risk of developing type 2 diabetes mellitus in adulthood was significantly higher in the famine-exposed group than that of non-exposed groupand the interactions were statistically significant.Conclusion:Early life famine exposure increases the risk of developing type 2 diabetes in adults, especially in women.
5.The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study
Yuanyue ZHU ; Long WANG ; Lin LIN ; Yanan HUO ; Qin WAN ; Yingfen QIN ; Ruying HU ; Lixin SHI ; Qing SU ; Xuefeng YU ; Li YAN ; Guijun QIN ; Xulei TANG ; Gang CHEN ; Shuangyuan WANG ; Hong LIN ; Xueyan WU ; Chunyan HU ; Mian LI ; Min XU ; Yu XU ; Tiange WANG ; Zhiyun ZHAO ; Zhengnan GAO ; Guixia WANG ; Feixia SHEN ; Xuejiang GU ; Zuojie LUO ; Li CHEN ; Qiang LI ; Zhen YE ; Yinfei ZHANG ; Chao LIU ; Youmin WANG ; Shengli WU ; Tao YANG ; Huacong DENG ; Lulu CHEN ; Tianshu ZENG ; Jiajun ZHAO ; Yiming MU ; Weiqing WANG ; Guang NING ; Yufang BI ; Yuhong CHEN ; Jieli LU
Gut and Liver 2024;18(4):719-728
Background/Aims:
Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China.
Methods:
A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted. Information on education level and lifestyle factors were obtained through standard questionnaires, while NAFLD and advanced fibrosis were diagnosed using validated formulas. Outcomes included the risk of NAFLD in the general population and high probability of fibrosis among patients with NAFLD. Logistic regression analysis was employed to estimate the risk of NAFLD and fibrosis across education levels. A causal mediation model was used to explore the potential mediators.
Results:
Comparing with those receiving primary school education, the multi-adjusted odds ratios (95% confidence intervals) for NAFLD were 1.28 (1.16 to 1.41) for men and 0.94 (0.89 to 0.99) for women with college education after accounting for body mass index. When considering waist circumference, the odds ratios (95% CIs) were 0.94 (0.86 to 1.04) for men and 0.88 (0.80 to 0.97) for women, respectively. The proportions mediated by general and central obesity were 51.00% and 68.04% for men, while for women the proportions were 48.58% and 32.58%, respectively. Furthermore, NAFLD patients with lower educational attainment showed an incremental increased risk of advanced fibrosis in both genders.
Conclusions
In China, a low education level was associated with a higher risk of prevalent NAFLD in women, as well as high probability of fibrosis in both genders.
6. Association between low handgrip strength and air pollution among people aged 50 years and over
Yanfei GUO ; Ye RUAN ; Hualiang LIN ; Wenjun MA ; Qingjun ZHANG ; Shuangyuan SUN ; Zhezhou HUANG ; Yang ZHENG ; Yan SHI ; Fan WU
Chinese Journal of Epidemiology 2019;40(10):1240-1244
Objective:
To examine the association between long-term exposure to ambient PM2.5 combined with indoor air pollution and handgrip strength among people aged 50 and over.
Methods:
Data were from the first wave of World Health Organization Study on global AGEing and adult health in China. Ambient annual concentration of PM2.5 was estimated by using the satellite data we also investigated the use of fuels and chimneys as indoor air pollution. A two-level (individual level and community level) linear model was applied to examine the association between long-term exposure to ambient PM2.5 combined with indoor air pollution and the handgrip strength.
Results:
A total of 13 175 individuals aged 50 years and over were included for analysis. The handgrip strength was (26.67±0.54) kg. Ambient PM2.5 was found to be significantly associated with the risk of decreased handgrip strength. Outdoor PM2.5 concentration was negatively correlated with handgrip strength (