OBJECTIVE:To investigate the effects of preemptive analgesia of parecoxib-sodium for radical mastectomy of breast cancer. METHODS:A total of 60 female patients underwent selective radical mastectomy of breast cancer under general anes-thesia were randomly divided into observation group(40 cases)and control group(20 cases). 15 min before anesthesia induction, observation group was given intravenous injection of Parecoxib-sodium for injection 40 mg. Control group was given intravenous in-jection of 0.9% Sodium chloride injection 5 mL. The pain visual analogue scale(VAS),the frequency of patient controlled intrave-nous analgesia(PCA)and ADR were observed between 2 groups at different time points after surgery. RESULTS:VAS scores of observation group were significantly lower than those of control group 2,4,6,8 h after operation,and the frequency of PCA 0-4, 4-12,12-24,24-36 h after operation was significantly lower than control group,with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS:The preemptive analgesia of parecoxib-sodium can effectively reduce pain degree of patients with breast cancer after radical mastectomy,the frequency of PCA, and do not increase the occurrence of ADR.

Objective To explore molecular mechanisms of dexmedetomidine(Dex)function as protec-tive effect on acute lung injury(ALI). Methods Hemorrhagic shock ALI rat model was constructed and divided into 6 groups at random:C group,control group;A group,ALI;G,ALI rat groups were treated with 5μg/kg;I1 group,ALI+PDTC(200 mg/kg);I2 group,ALI+STA-21(100 mg/kg). After 12 h modeled,all rats were anes-thetized and killed,and BALF was collected and the concentrations of TNF-α,IL-6,IL-1β,IL-4 were deter-mined using ELISA. HE staining to observe the morphology of lung tissue. Expression of NF-κB,STAT-3,p-STAT-3 proteins were determined using immunohistochemistry or Western blot. Results In A group,the structure of lung tissue were strongly destroyed ,a large number of neutrophils invasion and red blood cells leakage was found;lung tissue structure in G,I1 and I2 groups were gross integrity. The concentrations of TNF-α,IL-6,IL-1β,IL-4 in A group were significantly higher than C group(P<0.05). The concentrations of TNF-α,IL-6,IL-1β,IL-4 in G group,I1 group and I2 group was significantly lower than A group(P<0.05). The levels of NF-κB and p-STAT-3 protein in A group were obvious enhanced(P < 0.05)compared with G group,I1 group,I2 group,respectively. Conclusion Dex inhibited inflammatory to exert lung protective effect via inhibiting NF-κB,STAT-3 activation-induced by ALI.