Objective To evaluate the clinical curative effect and safety of the stapled transanal rectal resection (STARR) in treatment rectocele. Methods Ninety-two cases suffering from rectocele were treated with rectal inferior extremity half circum mucosectomy by PPH stapler. The operative time, operation effect,complication and recurrence rate were studied. Results All cases were operated successfully. The mean operation time was (25 ±8)min,The totol effective rate was 100% ,postoperative complication included inferior abdomen discomfort and pain (32 cases,34. 7%),urinary retention(9 cases,9. 8%) ,anal anus pain(5 cases, 5. 4%) and bleeding(3 cases,3. 3%). The average length of postoperative stay was 1-5 days (average[2. 2 ±0. 9]days). The follow-up period ranged from 4 to 40 months and no recurrence was observed. Conclusion The stapled transanal rectal resection (STARR) has several advantages,such as safety,rapid recovery,good recent therapeutic effect and lower recurrence in treating rectocele.

RNA interference (RNAi) is an effective antiviral mechanism of human body. It is a sequence specific process involving post transcriptional gene silencing initiated by double stranded RNA (dsRNA) homologous to the silenced genes. RNAi,as a genomic immune phenomenon involving the modulation of specific gene expression and an efficient gene-level defense mechanism against viral infection,has become the focus of study in biomedicine. This review summarized the researches of RNAi in inhibiting hepatitis virus infection,analyzed the advantages of RNAi in clinical treatment of hepatitis,and pointed out the existing problems,hoping to provide references for antiviral study of hepatitis infection.