Ovarian cancer is highly lethal despite multiple therapies, and new therapies are therefore needed.Retinoids are potential anticancer drugs that can promote apoptosis,inhibit growth and induce differentiation in cancer cells,and all these functions are regulated by the expression of retinoid receptors.Herein the recent researches on the expression of retinoid receptors in ovarian cancer are reviewed.

Problem oriented system teaching method has been put into practice,and contrast has been made with traditional teaching method in the teaching of diagnostics in the technical secondary school of Chinese and western medicine special field.Result indicates that the improved teaching effect has been obtained and the students'initiatives and their ability to learn independently have been cultivated.

Objective:To study the structural changes of upper airway i n the patients with Angle Ⅱ 1 malocclusion treated by orthodontic appliance. Methods:12 patients with Angle Ⅱ 1 malocclusion caused by mout h breathing were treated by rapid maxillary expansion (RME) of splint and Tip-E dge technology, the structure of upper airway was measured before and after trea tment,the data were analyzed. Results:After treatment PNS-Ba,SP P-SPPW,P-T,TB-TPPW,V-LPW,UC-LC and H-C3(hor) increased(P

Objective To investigate the protective effects of Apigenin (APG) on hepatic in diabetic rats.Methods The experimental diabetes model were made by intraperitoneal injecting STZ. The rats were randomly devided into six groups: a normal control group, a diabetes model control group, APG 5, 10, 20 and 40 mg/kg treated groups, and the drug was given by intraperitoneal injection. 4 weeks later, the body weight, ratio of hepatic weight and body weight were detected; the histopathological changes of hepatic tissue were observed by HE staining; the content of ALT/AST/LDH in serum were determined; the activity of SOD/GSH-Px/CAT and the content of MDA in hepatic tissue were determined.Results Compared with the diabetes model control group, the body weight of APG(10, 20, 40) mg/kg treated groups were significantly increased (261.3 ± 15.8 g, 274.2 ± 18.4 g, 265.9 ± 19.0 gvs. 250.8 ± 21.4 g,P<0.05 orP<0.01), and the ratio of hepatic weight and body weight were significantly decreased (27.7 ± 5.69, 26.2 ± 4.91, 27.3 ± 4.58vs. 32.9 ± 5.85,P<0.05 orP<0.01); the hepatic tissue histopathological changes of APG-treated groups were significantly improved; the level of ALT in serum of APG (5, 10, 20 and 40) mg/kg treated groups were significantly decreased (1 039.3 ± 453.9 U/L, 917.6 ± 445.2 U/L, 828.4 ± 309.5 U/L, 721.7 ± 318.3 U/Lvs. 1 205.2 ± 484.1 U/L;P<0.05 orP<0.01), AST were significantly decreased (97.8 ± 23.8 U/L, 90.1 ± 19.6 U/L, 81.7 ± 15.7 U/L, 86.4 ± 19.2 U/Lvs. 105.3 ± 25.7 U/L;P<0.05,P<0.01), LDH were also significantly decreased (983.7 ± 192.6 U/L, 918.3 ± 212.9 U/L, 830.4 ± 174.2 U/L, 871.8 ± 183.1 U/Lvs. 1 102.8 ± 211.6 U/L;P<0.05 orP<0.01); the activity of SOD in hepatic tissue of APG (10, 20, 40) mg/kg treated groups were significantly increased (10.5 ± 1.9 U/mg, 11.6 ± 2.1 U/mg, 10.5 ± 2.0 U/mgvs. 9.1 ± 1.8 U/mg,P<0.05,P<0.01), GSH-Px were significantly increased (14.2 ± 2.7 U/mg, 15.3 ± 2.9 U/mg, 14.6 ± 2.6 U/mgvs. 12.9 ± 2.3 U/mg;P<0.05, P<0.01), CAT were significantly increased (3.15 ± 0.90 U/mg, 3.58 ± 0.88 U/mg, 3.31 ± 1.09 U/mgvs. 2.58 ± 0.79 U/mg,P<0.05 orP<0.01), and the content of MDA was significantly decreased (5.03 ± 1.70 nmol/mg, 4.66 ± 1.51 nmol/mg, 4.73 ± 1.65 nmol/mg vs. 5.98 ± 1.62 nmol/mg;P<0.05 orP<0.01). And the treatment effect of APG 20 mg/kg groups was the most significant.Conclusion APG had antioxidant enzyme activity, besides its reducing the damage of free radical, and protecting the hepatic tissue of diabetic rats effects.

Objective To explore the prognostic factors in patients with acute respiratory failure due to chronic obstructive pulmonary disease (COPD) in EICU. Method Clinical data of 39 patients admitted to EICU from May 2005 to May 2007 were retrospectivley analyzed. Results In death group, the pulmonary artery pressure (PAP) ,creatinine (Cr) ,APACHE-Ⅱ score, and APACHE-Ⅲ score were increased (P < 0. 05) and ICU stays were prolonged (P < 0.05) ; Respiratory rate (RR) and Glasgow coma score (GCS) were decreased (P < 0.05). Conclusion PAP, Cr, APACHE-Ⅱ score,APACHE-Ⅲ score,RR and GCS predict the prognosis of the patients with acute respiratory failure due to chronic obstructive pulmonary disease.

Adult ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurotoxicity Syndromes ; diagnosis ; Retrospective Studies ; Tomography, X-Ray Computed

It is still controversial whether or not the severe pneumonia is associated with heart failure in children.Currently,we pay more attention to the pathophysiological procedure of heart failure,such as pneumonia complicated with respiratory failure,shock and myocardial injury.Pay attention to the cardiopulmonary interaction mechanism and systemic inflammatory response.According to different pathophysiological mechanisms,guide the treatment by monitoring the hemodynamic status.

Objective To study the relationship between angiotensin Ⅱ type 1 receptor (AT_~1 R) gene polymorphism and carotid atherosclerosis and pathogenesis in primary hypertension . Methods Polymerase chain reaction combined with restriction enzyme digestion and ultrasonography were used to measure AT_~1 R gene polymorphism and carotid artery intima-media thickness (IMT) separately in 150 patients with primary hypertension compared with 100 controls . Results The frequencies of AC genotype and C allele of AT_~1 R gene in patients were higher than those of control ~(P

Parkinson's disease is characterized by degeneration and dysfunction of dopaminergic neurons in the mid-brain substantia nigra, neurons that project to the caudate putamen. The clinical symptoms are caused by the loss of dopamine and the consequent dysfunction of the nigrostriatal pathway. Neurotrophic factors that may prevent nigrostriatal degeneration by improving the function of remaining dopaminergic neurons has the potential to be a useful therapy for Parkinson's disease. Neurotrophic factors and their specific receptors could play an important role in the progress of Parkinson's disease. The neuroprotective effects of neurotrophic factors GDNF, BDNF, IL-6 on dopaminergic neurons in vivo and in vitro , and the potential therapeutic use in treating Parkinson's disease were discussed in this paper.

Objective To investigate the effect of microRNA-204(miR-204)on autophagy in U251. Methods Inhibition of miR-204 in U251 cell lines was done by transfection of miR-204 inhibitor(AMO-204) .Cell viability was detected by MTT assay.The autophagy of U251 was tested by immunofluorescence tech-nique.The protein level of Beclin 1,LC3 and Bcl-2 was detected by Western blot.Results Cell viability was markedly increased after inhibition of miR-204 in U251 cells.The number of autophagosome was decreased.The levels of Beclin 1 and LC3 were decreased,the protein level of Bcl-2 was significant increased by transfection of AMO-204 in U251 cells(P<0.05).Conclusion MiR-204 might at least in part promote glioma via inhibi-ton autophagy,indicating that miR-204 might be a potential target for the treatment of glioma.