Sepsis is one of the most common causes of mortality in the intensive care units (ICUs) with high mortality rates which may be related to the lack of thoroughly understanding of the specific pathophysiological mechanisms.Improved treatment protocols have resulted in most patients got out of the initial hyperinflammatory phase and entered into a protracted immune suppressed phase.Deaths in this immunosuppressive phase are typically due to failure to control the primary infection or the secondary nosocomial infections often with opportunistic pathogens.As the complexity in multiple systems and varied mechanisms involved in the development of disease,the disorder of immune system and inflammation reaction may be one of the main mechanisms,which were mainly characterized by inflammation cytokines storm and immune dysfunction.The mechanism in the later course of disease may include apoptosis and depletion of immune cells,increased suppression of T regulatory cell and increased myeloid-derived suppressor cell,and cellular exhaustion.In this review we focus on the pathophysiologic mechanism of sepsis with immune compromized,monitoring the immune response,the cellular immunoadjuvant therapy,and improving the recognition of sepsis immunosuppression.

Objective To analyse the unqualified cause of unpaid blood donation blood test in Dianjiang County .Methods The screening results of ALT ,HBsAg ,HCV antibody ,HIV antibody ,TP antibody ,of blood donors ,and their personal information from 2008 to 2012 were collected .The statistics method was used to comparative analysis .Results Rate of unqualified of unpaid blood donation blood test was 4 .06% ;Rate of unqualified of ALT was 2 .37% ,anti-TP was 0 .85% ,HBsAg was 0 .77% ,anti-HCV was 0 .15% ,anti-HIV was 0 .07% .The rate of unqualified was higher among the blood donors ,young male person ,whose level of educa-tion was junior high school and below junior high school .Conclusion It should strength preliminary screening of blood donors and screening of high-risk donors .Collecting flood from low-risk and regular donors in case to improve the quality of blood donors and decrease the waste of blood .

"Conducting yang from yin, and conducting yin from yang" is the essential principle of acupuncture and moxibustion in treatment of diseases, originated from Neijing (Internal Classic). In clinical, yin and yang are not just limited as the natures of meridians and zangfu organs, but also refer to the locations of acupoints, such as the upper and the lower, the left and the right, the anterior and the posterior, the exterior and the interior. Besides, they include the time of acupuncture, such as four seasons and midnight-midday ebb flow, and the manipulation of acupuncture, etc. The ultimate goal of acupuncture is to regulate yin and yang.
Acupuncture Points ; Acupuncture Therapy ; Humans ; Meridians ; Seasons ; Yin-Yang

Acupuncture Therapy ; Female ; Humans ; Middle Aged ; Torticollis ; therapy

Adult ; Female ; Humans ; Lung Neoplasms ; complications ; microbiology ; Lymphoma ; complications ; microbiology ; Tuberculosis, Pulmonary ; complications

Acupuncture Therapy ; instrumentation ; methods ; Adult ; Aged ; Facial Paralysis ; therapy ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome

Sepsis is a severe systemic inflammatory response syndrome, and is common in the patients with infection, extensive burn injury and major surgery. As it may cause multiple organ dysfunction and septic shock, it is always accompanied with high mortality and poor prognosis. Currently there's no effective medication available for treatment of sepsis. During the process of killing bacteria, the classical antibiotics lead to release of a large quantity of proinflammatory cytokines, such as lipopolysaccharide, which exacerbates the malfunction of immune system. Furthermore, the growing number of multiresistant bacteria present a new challenge to the management of sepsis. Antimicrobial peptides (AMPs) are small, cationic, and amphipathic peptides with broad-spectrum microbicidal activity against bacteria, fungi and viruses. In addition, they also can neutralize endotoxin and suppress inflammatory cascade through multiple immunomodulation, which potentially serves as a promising alternative approach for sepsis treatment. This review briefly summarizes the progress of AMPs in the treatment of sepsis as well as the relevant mechanisms.

Pimavanserin is a selective 5-HT2A receptor inverse agonist approved by FDA on April 29, 2016, and it is the first drug for the treatment of hallucinations and delusions associated with Parkinson' s disease. Pimavanserin is with high safety, good toleration and promising clinical efficiency, which is a timely option to resolve the drug shortage in clinic treatment. This paper summarized its pharmacodynamics, pharmacokinetics, clinical studies, adverse reactions and drug interactions.

Objective To construct a T-bet response reporter gene, for the detection of T-bet tran-scriptional activity and application in high-throughput screening for the functional genomies. Methods The cis-acting DNA element, ThRE, based on CNS-22 T box site of IFN-γ gene, was recombined into a reporter vector pLUC-MCS. The reporter gene was transfected into HEK 293T cells to detect its response to T-bet. And the binding of T-bot to TbRE was identified with electrophoretic mobility shift assay(EMSA). Results ThBE was successfully cloned into pLUC-MCS, named as TbRE-LUC. Using a luciferase assay, expression of the reporter gene is found to be induced by T-bet in a dose dependent manner and correlate with T-bet ex-pression positively with activation up to 20 folds. Moreover, the binding specificity of T-bet to TbRE is vali-dated by EMSA. Conclusion We successfully constructed a T-bet response reporter gene, ThRE-LUC, which responds to T-bet keenly and specifically. TbRE-LUC will be a useful tool in high-throughput screen-ing for human genes associated with transcription activity of T-bet.