1.Clinical effect of PRP combined with calcium dobesilate in treatment of patients with DR
Li-Bo, WANG ; Jing, HUANG ; Shu-Yi, CHEN
International Eye Science 2017;17(9):1731-1733
AIM:To investigate the clinical effect of panretinal photocoagulation (PRP) combined with calcium dobesilate in treatment of diabetic retinopathy (DR).METHODS:Selected 120 cases (240 eyes) of DR diagnosed in our hospital from January 2011 to January 2016 were retrospectively analyzed.According to whether calcium dobesilate was used, the treatment group was divided into two groups.Sixty cases were treated with PRP combined with calcium dobesilate, and 60 cases in the control group were treated with PRP only.The BCVA, CMT and clinical efficacy of the two groups were compared.RESULTS:Before treatment, there was no significant difference on BCVA between combined group and control group (P>0.05).After treatment, BCVA of combined group was higher than that of the control group (P<0.01).Before the treatment, no statistically significant difference between combined group and control group on CMT, neovascularization and fluorescein leakage area were found (P>0.05);after treatment, the combination group on CMT, neovascularization and fluorescein leakage area value were less than the control group (P<0.01).After treatment, combined group was appearance effect in 65.0%, effective in 30.0%, invalid in 5.0%, the control group was 50.8%, effective 36.7%, invalid 12.5%, all statistically significant differences between the two groups (P<0.05).CONCLUSION:PRP combined with calcium dobesilate in treatment of DR has a more significant clinical effect than PRP alone.
2.Determination of Trace Cadmium by Microwave Digestion-Hydride Generation Atomic Fluorescence Spectrometry
Liyun ZHANG ; You-Yi ZHANG ; Shu-Chen LIU ;
Journal of Environment and Health 2007;0(07):-
0.999 3), the recovery rate was 96.9%-104.0%,RSD was 1.54%-2.03%. Conclusion The method is simple and rapid, with good sensitivity and selectivity, and it is applicable to the determination of trace cadmium in drinking water or food.
4.AIDS-related enteropathy due to Mycobacterium avium-intracellulare: report of a case.
Yi-Hua CHEN ; Li-Na AN ; Ke-Shu LUO ; Yi JIAN ; Yan LUO
Chinese Journal of Pathology 2009;38(10):709-710
Adult
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Antigens, CD
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metabolism
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Antigens, Differentiation, Myelomonocytic
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metabolism
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HIV Enteropathy
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complications
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metabolism
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microbiology
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pathology
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Humans
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Male
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Mycobacterium avium Complex
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isolation & purification
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Mycobacterium avium-intracellulare Infection
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complications
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metabolism
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microbiology
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pathology
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Young Adult
5.A comprehensive treatment for advanced gastric cancer with para-aortic lymph node metastasis
Shenghong WEI ; Yi WANG ; Zaisheng YE ; Junyin ZHENG ; Shu CHEN ; Yi ZENG ; Zhitao LIN ; Zhiwei WANG ; Xiaoling CHEN ; Luchuan CHEN
Chinese Journal of General Surgery 2021;36(4):244-248
Objective:To investigate the safety and prognostic value of neoadjuvant chemotherapy and surgery for advanced gastric cancer patients with para-aortic lymph node metastasis.Methods:Clinicopathological data of 25 patients admitted to the Department of Gastrointestinal Surgery, Fujian Cancer Hospital from Jan 2015 to Jun 2017 were retrospectively analyzed. All patients were treated with SOX chemotherapy for 3 cycles. D 2 + paraaortic lymphadenectomy was performed in patients with stable disease (SD) . After operation, SOX regimen was used for 5 cycles of chemotherapy. Results:After 3 cycles of neoadjuvant chemotherapy, there were 2 cases with progressive disease, 6 cases of SD and 17 cases of partial remission. There was no treatment-related death. Twenty-three patients underwent surgery, including 19(76%) patients of R 0 resection. Tirty-four out of 128 para aortic lymph nodes were metastatic. Postoperative complications occurred in 5(22%) patients, with no mortality . The median progression free survival time and median overall survival time were 20 and 29 months respectively. The 1, 3-year overall survival rates were 80% and 48%, and the 1-year and 3-year progression free survival rates were 72% and 38%, respectively. For those with para-aortic lymph node metastasis the 1-year and 3-year OS rate were 70% and 17%, respectively. Multivariate analysis showed that the efficacy of neoadjuvant chemotherapy was an independent prognostic factor. Conclusion:Neoadjuvant chemotherapy is among others an independent prognostic factor affecting the post-op survival of advanced gastric carcinoma with para-aortic lymph node metastasis.
6.Comparative analysis of effect of two kinds of biological agents in volume-reduced bullae
Huifang CUI ; Xujun CHEN ; Wenqiao HUANG ; Yi SHU ; Yiqun WU ; Jianlong HUANG ; Huimin CHEN ; Ye LU
Chinese Journal of Primary Medicine and Pharmacy 2014;(20):3054-3056
Objective To retrospectively analyze the effect of two kinds of biological agents in volume -re-duced bullae .Methods 11 patients who suffered from bullae were operated under large C-arm locating ,and infused two kinds of biological agents through micro catheter of fibreoptic bronchoscopy .All of them were randomly divided into the two groups .The biological agents in group A were fibrinogen and diluent thrombin , and that of group B was Porcine Fibrin Sealant Kit .In group A,the micro catheter with diameter of micro thread less than 1.2mm was placed in bullae through fibreoptic bronchoscope ,and then the 2mL lidocaine,5 ml fibrinogen,and double of 500u diluent thrombin were inproperorder injected through micro catheter .In group B,the Porcine Fibrin Sealant Kit was injected at the same method,and then the suspension fluid was exacted .The operation time was recorded ,and then the clinical efficacy and incidence rate of complications were compared .Results The operation time of group A was 5-15 minutes, and that of group B was 6-20 minutes.For all the patients ,4 cases were totally effective ,2 cases were significantly effective,and 2 cases were totally non-effective.The total effective rate was 81.82%(9/11).The incidence rates of common complications in group A and B were 52.38%(22/42),58.33%(14/24),respectively,the difference was not significant (χ2 =0.22,P>0.05).Moreover,there were no serious complications in all cases .Conclusion The security and effect of two kinds of biological agents might be well enough ,but in view of less cases ,they were worth to further popularized and applied in clinical practice .
7.Advances in diabetic erectile dysfunction.
Shu-Yan HUANG ; Shu CHEN ; Yi-Ping FENG
National Journal of Andrology 2006;12(2):178-182
Erectile dysfunction is common complication of diabetes mellitus. The incidence of diabetes mellitus induced erectile dysfunction (DMED) is 20% - 75%. DMED appears to be due to vascular-neuropathic and corpus cavernosum smooth muscular damage. To control blood glucose, blood pressure and blood lipids is the basis of DMED therapy. In 50% of the patients with DMED, the phosphodiesterase 5 inhibitors is effective, while intracavernous pharmacotherapy is effective for more than 90%. Penile prosthesis implantation continues to be the treatment of choice in case of other therapy failure.
Animals
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Diabetes Complications
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epidemiology
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Diabetes Mellitus, Type 2
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epidemiology
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Erectile Dysfunction
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epidemiology
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pathology
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therapy
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Humans
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Male
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Rabbits
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Rats
8.Long-term versus short-term introvesical chemotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis of the published results of randomized clinical trials.
Teng, LI ; Yi, XING ; Shu-Cheng, LIU ; Xiao-Min, HAN ; Wen-Cheng, LI ; Min, CHEN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2014;34(5):706-15
In order to assess the effect of long-term versus short-term intravesical chemotherapy in preventing the recurrence of patients with non-muscle-invasive bladder cancer, we searched several databases with words as mesh terms and free text words to find all eligible randomized clinical trials (RCTs) for the comparison of the two strategies of instillation durations. "Observed-Expected events research (O-E)" and "Variance (V)" for calculating hazard ratio (HR) were used in Revman 5.2 software recommended by Cochrane Collabration for data analysis. Sensitivity and subgroup analysis were selected to minish heterogeneity. GRADEpro 3.6 profile recommended by Cochrane Collabration was employed for quality assessment of analyses. Finally, 13 eligible RCTs with 4216 patients were included in this review and 16 comparisons from 13 trials were involved for analysis. The pooled analysis revealed no significant difference between long-term and short-term duration [HR=0.99, 95% CI (0.89, 1.11), P=0.89]. Within the subgroup analysis, patients benefited from long-term instillations with a start regimen of one immediate instillation [HR=0.83, 95% CI (0.69, 1.00), P=0.05]. But patients were not suitable to receive long-term instillations with epirubicin (EPI) [HR=1.01, 95% CI (0.91, 1.13), P=0.78]. The progression rate was not reduced after long-term instillations [HR=0.96, 95% CI (0.66, 1.39), P=0.82]. From our results, patients should not receive introvesical chemotherapy more than half a year. In contrast, patients with one immediate instillation are preferred to have a long-term duration at least one year. Long-term instillations can not reduce the progression rate.
9.Preliminary study of fertilizer effect on yield and quality of Fritillaria ussuriensis.
Tiezhu CHEN ; Lianxue ZHANG ; Xianjian ZHOU ; Guangming SHU ; Yi ZHOU
China Journal of Chinese Materia Medica 2009;34(5):544-546
OBJECTIVETo preliminarily study the effect of fertilizer methods on the yield and quality of Fritillaria ussuriensis.
METHODThrough the investigation of the available nitrogen, phosphorus, potassium in soil fertility of F. ussuriensis planting field as well as the measurement of total nitrogen, phosphorus, potassium contents in bulbus of F. ussuriensis, the balanced fertilization plan for cultivation of F. ussuriensis was made.
RESULTThe optimal fertilizing amount was 13.0 kg x m(-2) pig dung, or 5.5 kg x m(-2) deer dung and 6.5 kg x m(-2) pig dung, or 11.0 kg x m(-2) deer dung.
CONCLUSIONEffective fertilizing may increase significantly the yield and quality of F. ussuriensis.
Agriculture ; methods ; Biomass ; Fertilizers ; analysis ; Fritillaria ; growth & development ; Soil ; analysis
10.Pharmacokinetics of dauricine in dogs
Shu-Juan CHEN ; Bin ZHANG ; Yi-Mei YANG ; Zong-Shun DAI ; Fan-Dian ZENG ;
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(03):-
K21. The mean t1/2(?) was (2.7?0.4) h, Vd was about 11.18 L?kg-1.The C-T profile conformed to two compartment open model. The plasma Dau concentration-time curves showed a double-peak phenomenon in all dosages of all dogswhen dauricine was given by intragastric was.The tpeak(1) was (0.8?0.6) ~(1.2?0.5) h,tpeak(2) was (5.2?3.2) ~(6.5?1.9)h,Cmax(2) 0.05) and the AUC was increased in proportion.The drug is eliminated non-linearly when the dosage is above 50 mg?kg-1, the parameters t1/2(el),CL, AUC/X0 shows great difference (P