Graves' disease,the most common disorder of hyperthyroidism,is an autoimmune disease related with autoantibody (TRAb),with the specific mechanism remaining incompletely understood.The therapies for Graves disease include three conventional methods:anti-thyroid drugs,radioiodine and surgery.Only treatment with anti-thyroid drugs is aimed at the immune factor;they can eliminate TRAb and lead to recovery ultimately.Literatures have drumed in that treatment with anti-thyroid drugs was a basic therapy for Graves' diseases,and they were the first choice to cure hyperthyroidism all over the world (except for the U.S.A).The drugs do not destroy the structure of thyroid follicle,and are safe and efficient;moreover,their effect is reversible and therefore do not cause permanent damage to the thyroid.Anti-thyroid drugs not only can be used alone,it also can be used before radioiodine or surgery.ATA chairman professor Cooper(NEJM,2005) propounded a therapy path for Graves' disease,which is helpful for clinical practice.

OBJECTIVE:To analyze the cause-related marketing strategy in pharmaceutical industry.METHODS:The theory of cause-related marketing was introduced and the cause-related marketing pattern was illustrated with examples.RESULTS&CONCLUSION:Pharmaceutical enterprises can achieve win-win effect in both economic returns and social effects by selecting suitable public welfare projects and applying cause-related marketing.

Air ; analysis ; Chromatography, Gas ; methods ; Naphthalenes ; analysis ; Workplace

OBJECTIVE: To recognize the research status on the mechanism of reactive oxygen species (ROS) and NADPH oxidases in cell growth and death,and explore the effects of ROS and NADPH oxidases on cardiomyocyte differentiation.DATA SOURCES: A computer-based online search of Medline was undertaken for the articles about the action mechanism of reactive oxygen and NADPH oxidases in cell growth and death published in English between January 1997 and December 2003 with the key words of "Reactive oxygen species, NADPH oxidase, Cardiomyocytes, Differentiation, Signal transduction".STUDY SELECTION: Inclusive criteria: ①Articles on ROS production and structure and activation of NADPH oxidase and their action mechanism in cell growth and death; ②Research about the molecule mechanism of cardiomyocytes differentiation. The repetitive research and review articles were excluded.DATA EXTRACTION: Totally 132 articles about the action mechanism of ROS and NADPH oxidase and cardiomyocytes differentiation were collected, and 78 ones met the inclusive criteria.DATA SYNTHESIS: ①ROS involved in pathogenesis of many diseases were mainly from intramitochondrial electron transport chains, and NADPH oxidase was closely related with ROS production; NADPH oxidase firstly found in phagocyte was a kind of multienzyme complex, and its activity was regulated by the concentration of Ca2+ in cells and mRNA expression of its subunits. ②At present, many researchers presumed that oxidative stress was a double-edged sword, and it two-ways regulated the cell proliferation and death, in which ROS served as the second messenger in the signal transduction. Recent data showed that ROS and NADPH oxidase played important roles in cardiomyocytes differentiation; however, it was not identified which subunit of NADPH oxidase expressed in myocardial cells and its detail regulative pathway. Those problems were important for further study in the molecule mechanism of cardiomyocytes differentiation.CONCLUSION: ROS including superoxide anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH-), are generated in cardiomyocytes mainly by a membrane-bound NADPH oxidase (NOX). The NOX-derived ROS, as the second passenger, play important roles in various intracellular signaling pathways. In cardiomyocytes, ROS have the potential to alter the balance between cell growth and death through these signaling pathways. Recently,ROS have been demonstrated to play a critical role in regulation of cardiomyocyte differentiation from embryonic stem cells. Research in the regulation mechanisms of ROS will contribute to our better understanding of he role of ROS and NADPH oxidase in cardicomyocyte differentiation and will lead to the identification of factors able to promote cardiac differentiation.

OBJECTIVE:To study the new factor for marketing competition of pharmaceutical enterprises-CSI.METHO_DS:Analysis was based on the domestic and foreign documents,and combined with the actual situations of pharmaceutical enterprises in China.RESULTS & CONCLUSIONS:Only by increasing the level of CSI and establishing the CS ideas,do the medical enterprises succeed in the furiously competitive market.

OBJECTIVE: To study relation between the packaging of pharmaceutical products and the safety of drug use. METHODS: Analysis was based on the relevant documents, and combined with the actual situations in China. RESULTS & CONCLUSION: Only by selecting the appropriate packaging materials, controlling the packaging process effectively and man- aging the package labels, will the safety of drug use be ensured.

Objective To investigate effect of Hongjingtian injection adjuvant therapy on blood glucose, blood lipid and clinical efficacy in patients with acute cerebral infarction.Methods 40 cases of acute cerebral infarction in our hospital were randomly divided into control group and experimental group.20 cases in control group were treated with routine treatment, 20 cases in experimental group were treated on the basis of control group by Hongjingtian injection.Fasting blood glucose, blood lipids and clinical efficacy were compared post-treatment.Results Compared with pre-treatment, the level of LDL-C and TC in control group was lower(P <0.05), the levels of FBG, TC, TG and LDL-C in experimental group were lower (P <0.05), and the HDL-C level was higher (P<0.05).Compared with control group, the levels of LDL-C, TG, TC and FBG in experimental group were lower (P<0.05), and the HDL-C level was higher (P<0.05).The total effective rate of experimental group (95.00%) was higher than control group (65.00%)(P<0.05).Conclusion Hongjingtian injection can decrease the level of fasting blood glucose in patients with acute cerebral infarction and decrease serum TG, TC, LDL-C level, increase the level of HDL-C, improve the clinical efficacy, and have a guiding significance for clinical.

Objective To study the roles of protein kinase C (PKC) in the signal transduction pathway of LPS induced nuclear transcription factor (NF) ?B activation of alveolar macrophages(AMs). Methods NF ?B level in nuclear protein extraction of AMs was detected by sandwich ELISA. Intranuclear translocation of NF ?B was observed by immunocytochemical staining. Results LPS could induce NF ?B activation of AMs in time and dose dependent manners. Immunohistochemical staining revealed intranuclear translocation following LPS induction. Specific calphostin C (Cal C) and pyrrolidine dithiocarbamate (PDTC) could inhibit LPS induced NF ?B activation. Conclusion PKC, as a up stream messenger, is involved in the signal transduction pathway of LPS induced NF ?B activation.

Objective To study the curative effect of gearing lumbar disc herniation with intecverthral disc version operation. Methods 220 patients were randomly recruited into a treatment group (with 120 patients) and a control group (with 100 patients). The treatment group was treated with intervertbral disc version operation, and the control group was treated with epidural injection combined with massage therapy. Evaluate the therapeutic effects at 1 week, three months, and one year after the treatment respectively. Results The therapeutic effect of at 1 week, three months, and one year after the treatment was 83.46%, 86.19%, 93.45% respectively in the treatment group, and 64.68%, 69.08%, 71.04% respectively in the control group. The difference between the two groups was significance. (P<0.05). Conclusion Intervertbral disc version operation was safe and effective in treating lumbar disc herniation.

Objective To evaluate endovascular aortic repair for retrograde Stanford type A aortic dissection with an entry tear in the descending aorta.Methods From April 2006 to Dec 2012,31 patients with retrograde type A aortic dissection were treated with endovascular technique.22 patients had pleural effusion,14 patients had patent false lumen in the ascending aorta.Emergency operation was performed in 2 patients with acute right renal artery and right common iliac artery ischemia respectively.29 patients received endovascular treatment after 3 weeks conservative treatment.Chimney technique was used in 3 patients.Results All procedures were technically successful without severe complications.Ascending aorta recovered 1-3 months after operation.Pleural effusion subsided 3 days to 3 weeks after endovascular treatment.During follow-up of (31 ± 18) months,no severe complications developed,all the stent-grafts placed by chimney technique were patent.Conclusions Endovascular aortic repair can be used in the treatment of retrograde Stanford type A aortic dissection.Chimney technique can be used to reconstruct supra-aortic branches.