Graves' disease,the most common disorder of hyperthyroidism,is an autoimmune disease related with autoantibody (TRAb),with the specific mechanism remaining incompletely understood.The therapies for Graves disease include three conventional methods:anti-thyroid drugs,radioiodine and surgery.Only treatment with anti-thyroid drugs is aimed at the immune factor;they can eliminate TRAb and lead to recovery ultimately.Literatures have drumed in that treatment with anti-thyroid drugs was a basic therapy for Graves' diseases,and they were the first choice to cure hyperthyroidism all over the world (except for the U.S.A).The drugs do not destroy the structure of thyroid follicle,and are safe and efficient;moreover,their effect is reversible and therefore do not cause permanent damage to the thyroid.Anti-thyroid drugs not only can be used alone,it also can be used before radioiodine or surgery.ATA chairman professor Cooper(NEJM,2005) propounded a therapy path for Graves' disease,which is helpful for clinical practice.

OBJECTIVE:To analyze the cause-related marketing strategy in pharmaceutical industry.METHODS:The theory of cause-related marketing was introduced and the cause-related marketing pattern was illustrated with examples.RESULTS&CONCLUSION:Pharmaceutical enterprises can achieve win-win effect in both economic returns and social effects by selecting suitable public welfare projects and applying cause-related marketing.

Objective To study the curative effect of gearing lumbar disc herniation with intecverthral disc version operation. Methods 220 patients were randomly recruited into a treatment group (with 120 patients) and a control group (with 100 patients). The treatment group was treated with intervertbral disc version operation, and the control group was treated with epidural injection combined with massage therapy. Evaluate the therapeutic effects at 1 week, three months, and one year after the treatment respectively. Results The therapeutic effect of at 1 week, three months, and one year after the treatment was 83.46%, 86.19%, 93.45% respectively in the treatment group, and 64.68%, 69.08%, 71.04% respectively in the control group. The difference between the two groups was significance. (P<0.05). Conclusion Intervertbral disc version operation was safe and effective in treating lumbar disc herniation.

Objective The study is to investigate the effect of tanshinone on lung reperfusion injury. Methods 24 New-Zealand rabbits were randomly divided into two groups. In one group, the lungs were perfused and preserved with LPD solution, the other with LPD+ tanshinone solution. The isolated lungs were preserved for 18 hours and then reperfused with rewarming whole blood. After reperfusing 30 minutes the lung samples were examined by pathology, wet/dry weight and measure of NO, SOD and MDA. Results In two groups, the reperfusion injury lungs were fresh, but had partial congestion, edema and ecchymoma under naked eye, under light microscopy the structures of the pulmonary vesiculars, branchia and capillaries were complete, but the epithelial cells of the vesicles and capillaries in the LPD group were more swelling and hypertrophy than that in LPD+ tanshinone group. The wet/dry weight ratio was significantly lower in LPD+ tanshinone group than in the LPD group. NO [(2.16±2.15)μmol/g] and SOD [(37.03±18.01NU/mg] were higher in the LPD+ tanshinone group than in the LPD group [(0.68±0.33) μmol/g, (17.63±11.04)NU/mg] (all P<0.05), MDA was lower in the LPD+ tanshinone group [(0.47±0.20)μmol/mg] than in the LPD group [(0.86±0.44)μmol/mg] (P<0.05). Conclusions Tanshinone can dean oxygen free radical and is of stronger antioxidation, results in alleriating of lung reperfusing injury. Tanshinone has positive effect on preservative quality of the reperfusion injury lung.

OBJECTIVE: To recognize the research status on the mechanism of reactive oxygen species (ROS) and NADPH oxidases in cell growth and death,and explore the effects of ROS and NADPH oxidases on cardiomyocyte differentiation.DATA SOURCES: A computer-based online search of Medline was undertaken for the articles about the action mechanism of reactive oxygen and NADPH oxidases in cell growth and death published in English between January 1997 and December 2003 with the key words of "Reactive oxygen species, NADPH oxidase, Cardiomyocytes, Differentiation, Signal transduction".STUDY SELECTION: Inclusive criteria: ①Articles on ROS production and structure and activation of NADPH oxidase and their action mechanism in cell growth and death; ②Research about the molecule mechanism of cardiomyocytes differentiation. The repetitive research and review articles were excluded.DATA EXTRACTION: Totally 132 articles about the action mechanism of ROS and NADPH oxidase and cardiomyocytes differentiation were collected, and 78 ones met the inclusive criteria.DATA SYNTHESIS: ①ROS involved in pathogenesis of many diseases were mainly from intramitochondrial electron transport chains, and NADPH oxidase was closely related with ROS production; NADPH oxidase firstly found in phagocyte was a kind of multienzyme complex, and its activity was regulated by the concentration of Ca2+ in cells and mRNA expression of its subunits. ②At present, many researchers presumed that oxidative stress was a double-edged sword, and it two-ways regulated the cell proliferation and death, in which ROS served as the second messenger in the signal transduction. Recent data showed that ROS and NADPH oxidase played important roles in cardiomyocytes differentiation; however, it was not identified which subunit of NADPH oxidase expressed in myocardial cells and its detail regulative pathway. Those problems were important for further study in the molecule mechanism of cardiomyocytes differentiation.CONCLUSION: ROS including superoxide anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH-), are generated in cardiomyocytes mainly by a membrane-bound NADPH oxidase (NOX). The NOX-derived ROS, as the second passenger, play important roles in various intracellular signaling pathways. In cardiomyocytes, ROS have the potential to alter the balance between cell growth and death through these signaling pathways. Recently,ROS have been demonstrated to play a critical role in regulation of cardiomyocyte differentiation from embryonic stem cells. Research in the regulation mechanisms of ROS will contribute to our better understanding of he role of ROS and NADPH oxidase in cardicomyocyte differentiation and will lead to the identification of factors able to promote cardiac differentiation.

Objective: To measure the convergence angles of teeth in different teeth positions and different denture designs.Methods:Mesio-distal widths and labio-lingual widths were measured on 226 teeth according to three points in a line on three surfaces (gingival, middle and incise) of each tooth.The distance between every point and the counterpart point in the adjacent surface was measured.Then convergence angles were calculated. Results:The means of the angles were 4.13°±0.77°,4.14°±0.76°, 4.46°±0.95°, 4.76°±0.84° on the first and second premolar, the first and second molar,respectively . There were significant differences between the premolars and molars(P<0.05).On the dentures with the designs of monocrown, triunit-bridge and long bridge the means of the angles were 3.78°±0.74°,4.69°±0.75° and 5.08°±0.85° respectively,the angle on the denture with the design of monocrown was smaller than that of bridge (P<0.05).Conclusion:The convergence angles are different according to different teeth positions and different denture designs, so they should be adjusted according to the clinical requirements.

Objective To investigate effect of Hongjingtian injection adjuvant therapy on blood glucose, blood lipid and clinical efficacy in patients with acute cerebral infarction.Methods 40 cases of acute cerebral infarction in our hospital were randomly divided into control group and experimental group.20 cases in control group were treated with routine treatment, 20 cases in experimental group were treated on the basis of control group by Hongjingtian injection.Fasting blood glucose, blood lipids and clinical efficacy were compared post-treatment.Results Compared with pre-treatment, the level of LDL-C and TC in control group was lower(P <0.05), the levels of FBG, TC, TG and LDL-C in experimental group were lower (P <0.05), and the HDL-C level was higher (P<0.05).Compared with control group, the levels of LDL-C, TG, TC and FBG in experimental group were lower (P<0.05), and the HDL-C level was higher (P<0.05).The total effective rate of experimental group (95.00%) was higher than control group (65.00%)(P<0.05).Conclusion Hongjingtian injection can decrease the level of fasting blood glucose in patients with acute cerebral infarction and decrease serum TG, TC, LDL-C level, increase the level of HDL-C, improve the clinical efficacy, and have a guiding significance for clinical.

Cytokine-induced killer (CIK) cells play important roles in the treatment of solid tumors.In particular,they have broad application prospects for the patients with recurrence or metastasis.Although recently CIK treatment strategy has achieved encouraging results in preclinical studies,there are still some difficulties in the clinical applications.Some key issues remain to be resolved,such as how to ensure that the antitumor immune effector can be a lot of amplified and can stay longer in the body,how to selectively kill tumor cells,and how to ensure the security of application.

Objective To evaluate endovascular aortic repair for retrograde Stanford type A aortic dissection with an entry tear in the descending aorta.Methods From April 2006 to Dec 2012,31 patients with retrograde type A aortic dissection were treated with endovascular technique.22 patients had pleural effusion,14 patients had patent false lumen in the ascending aorta.Emergency operation was performed in 2 patients with acute right renal artery and right common iliac artery ischemia respectively.29 patients received endovascular treatment after 3 weeks conservative treatment.Chimney technique was used in 3 patients.Results All procedures were technically successful without severe complications.Ascending aorta recovered 1-3 months after operation.Pleural effusion subsided 3 days to 3 weeks after endovascular treatment.During follow-up of (31 ± 18) months,no severe complications developed,all the stent-grafts placed by chimney technique were patent.Conclusions Endovascular aortic repair can be used in the treatment of retrograde Stanford type A aortic dissection.Chimney technique can be used to reconstruct supra-aortic branches.

Toll-like receptor( TLR) ,which belongs to pattern recognition receptor,is type I transmem-brane glycoprotein. TLR activates natural immune and induces several cytokines. Foreign studies have showed that bacterial infection is closely related with TLR. In this paper,the relationship between TLR and bacterial in-fection is reviewd.