Humans ; Periodontal Diseases ; complications ; microbiology ; Periodontium ; microbiology ; Systemic Inflammatory Response Syndrome ; microbiology

Equipment Design ; Humans ; Pacemaker, Artificial

Colorectal Neoplasms ; diagnosis ; prevention & control ; Humans ; Translational Medical Research

Objective To explore the prognostic factors of osteosarcoma.Methods Clinical data of 32 cases with osteosarcoma were retrospectively reviewed.Sex,age,course of disease,serum level of alkaline phosphatase (AKP),tumor size,tumor site,Enneking surgical stage,surgical method and distant metastasis were statistically analyzed.Results All the patients were followed up,and 12 patients died with a median survival of 6-52 (40.28 ± 5.58) months.Overall survival rate of 3 years was 62.5％ (20/32).Univariate analysis revealed that the prognosts of osteosarcoma was significantly related to tumor site,Enneking surgical stage,surgical method and distant metastasis.Multivariate analysis suggested that Enneking surgical stage,surgical method and distant metastasis were independent prognostic factors.Conclusions Enneking surgical stage,surgical method and distant metastasis are independent prognostic factors.Early diagnosis and the radical resection of tumor can improve the prognosis.

ObjectiveTo explore salivary concentration of carcinoembryonic antigen (CEA),interleukin (IL)-6,IL-8 in oral squamous cell carcinoma and its' clinical significance.MethodsForty-two cases with oral squamous cell carcinoma were selected as experience group and 50 healthy persons as control group.ELISA method was performed to detect CEA,IL-6,IL-8 level of salivary and serum in two groups.ResultsThe salivary concentration of CEA,IL-6 and IL-8 was (62.37 ± 20.80)μ g/L,(79.12 ± 30.26)ng/L,( 834.61 ± 231.85 ) ng/L respectively in experience group,(25.72 ± 12.65 ) μ g/L,(0.58 ± 0.25 ) ng/L,(209.71 ± 67.92) ng/L in control group.There was significant difference between two groups(P＜ 0.01 ).The serum concentration of CEA,IL-6 and IL-8 was(61.15 ± 23.69)μ g/L,(58.17 ± 12.83) ng/L,(852.31 ±172.97) ng/L respectively in experience group,and IL-6 level of serum were much lower than that of salivary (P ＜ 0.05).ConclusionsCEA,IL-6 and IL-8 can be biomarkers of oral squamous cell carcinoma.Salivary detection is an ideal auxiliary diagnosis method for its simplicity and sensitivity.

The organic cation transport systems were initially recognized in studies of renal elimination.A variety of endogenous and exogenous compounds that are harmful to the body are eliminated from the kidney via glomerular filtration and/or active tubular secretion.Among those compounds are polar organic cations that require a transporter-mediated process to cross cellular membrane and be eventually excreted into the urine.The organic cation transport systems in the kidney have been recognized for several decades.Following the insight gained from the kidney,organic cation transporters (OCTs) have also been characterized in other tissues.In particular,the OCTs in the liver and in the intestine have been proposed as important determinants of drug absorption and disposition.Over the past several decades,the mechanisms of organic cation transport have been extensively characterized using in vivo models,ex vivo organ perfusions,in vitro tissue preparations and cell lines.In particular,the molecular cloning and characterization of OCTs have remarkably increased our knowledge of this important subfamily of solute carriers.In this article,we first review the molecular cloning and characterization of OCTs.We will then describe their transport mechanisms,tissue distribution and localization,and their specificity of interaction with organic cations.Regulatory mechanisms and genetic animal models will be reviewed as they provide the most important insight on this class of transporters in recent years.Finally,we will summarize genetic variation in human OCT genes and raise clinical perspectives on these important transporters.

Objective To investigate the therapeutic effect of distal radius fractures operation.Methods Eighty distal radius fractures patients who were treated from January 2010 to January 2011 were divided into observation group and control group by random digits table method,each group had 40 cases.The observation group was treated with plate internal fixation,the control group took closed reduction and splint external fixation.The palmar tilt,radial ulnar deviation,axial shortening before treatment and after treatment for 3 months were compared between two groups.The clinical curative effect after treatment for 1 year was compared.Results The palmar tilt,radial ulnar deviation,axial shortening before treatment between two groups had no significant difference (P ＞ 0.05).After treatment for 3 months,the palmar tilt,radial ulnar deviation,axial shortening in observation group were (17.0 ± 1.6)°,(23.0 ± 2.1)°,(1.0 ± 0.2) mm,in control group were (4.0 ± 0.8)°,(10.0 ± 1.1)°,(4.0 ± 1.1) mm,there was significant difference(P＜ 0.05).After treatment for 1 year,the excellent and good rate in observation group was 90.0％(36/40),significantly higher than that in control group [50.0％ (20/40)] (P ＜ 0.05).Conclusion Plate internal fixation in the treatment of distal radius fractures is more conductive to the wrist recovery of joint structure and function,reduce the occurrence of wrist joint dysfunction,improve the quality of life,and is worth to be applied in clinic.

Objective:To explore the diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer.Methods:Using pathological examination,or at least one-year clinical follow-up results for the gold standard,we divided patients with liver disease into three two groups:primary liver cancer group,benign liver disease group and normal group,using protein chip technology to detect the measurement serum tumor markers.Results:CA199,CEA,CA242,FER,AFP,CAl25 and CA153 were significantly higher in PHC group than those in benign liver disease group and normal group(P

Interferon regulatory factor 5 (IRF-5) can induce the expressions of IFN-α,IFN-β and promote the secretion of cytokines,including IL-6,IL-12 b,IL-17,IL-23,TNF etc.IRF-5 is involved in the process of immune response,cell growth,cell differentiation,cell apoptosis,tumorigenesis and cell signal transduction.For that reason,IRF-5 plays an important role in the occurrence and progress of many diseases in humans.Further studies of IRF-5 will better elucidate the pathogenesis of related diseases and provide theoretical basis for treatment of these diseases and the corresponding therapeutic targets.

The origin and termination of the reticulospinal tract were studied with HRP technique in ten cats by injecting HRP into the spinai dorsal horn or gray matter on one side of the cervical or lumbar enlargement, It was discovered that the reticulospinal neurons were located not only in the medial part of the medullopontal tegmentum, but also in its lateral part. There were also a few scattered labeled neurons in the reticular formation of midbrain. The reticulospinal tract ended in the spinal dorsal horn as well as in the ventral horn. The reticulospinal tract mainly originated from the ventromedial part of the medulla and pons. In this region the labeled cells were most numerous in the nucleus gigantocellularis, less in the nucleus medulla oblongatae centralis subnucleus ventralis and the nucleus pontis centralis caudalis, and much less in the nucleus pontis centralis oralis, the nucleus paragigantocellularis laterlris and the paramedium reticularis subnucleus ventralis. Occasionally a few scattered abeled cells could be seen in the nucleus cuneiformis. The reticulospinal fibers from these nuclei projected bilaterally to both cervical and lumbar enlargments of the spinal cord except that the nucleus cuneiformis projected bilaterally to the cervical enlargement only.Two groups of labeled cells were found in the ventrolateral part of the medullary and pontal reticular formation, corresponding to the position of group A 1 and A 7 of noradrenergic neurons respectively.The reticulospinal tract derived from the medial part of the brain stem terminated predominately in the gray matter ventral to the spinal dorsal horn, but a few of them ended in the dorsal horn. These connections provide direct pathways for the control of motor and sensory functions of the spinal cord by medial reticular formation.It has been proved by Brodal with chromatolysis techenique that every cell in the nucleus paramedium reticularis sends its efferent fiber to the spinal area of cerebellum, but in this study labeled cells were found in e nucleus paramedium reticularis subnucleus ventralis. We suppose that the axons of these labeled neurons may be divided into two branches, one projecting to the cerebellum and the other to the spinal cord.It is noteworthy that we also found some labeled neurons in the nucleus medullae oblongatae centralis subnucleus dorsalis and nucleus parvocellularis, the so called "receptive region" of the reticular formation. The fibers originating from this region terminated in the spinal dorsal horn mainly, suggesting that this tract probably influences the sensory function of the spinal cord. It seems that the conception of the lateral reticular formation of the brain stem as a pure "receptive area" of the reticular formation may have be modified.