Colorectal Neoplasms ; diagnosis ; prevention & control ; Humans ; Translational Medical Research

Humans ; Periodontal Diseases ; complications ; microbiology ; Periodontium ; microbiology ; Systemic Inflammatory Response Syndrome ; microbiology

Equipment Design ; Humans ; Pacemaker, Artificial

Intracranial pressure monitoring is a mainstay in the management of children with severe traumatic brain injury.The research issues on the intracranial pressure monitoring have become important for neurocritical care.This paper has reviewed the significance of intracranial pressure monitoring in children with severe traumatic brain injury.

BACKGROUND:There is no unified conclusion on the efficacy of immediate implantation and restoration. Some studies have shown that the success rate and aesthetic effect of immediate implantation are better than those of delayed implantation. However, in other studies, the immediate implantation has no difference from the delayed implantation, and it also has safety hazards. OBJECTIVE:To observe the clinical efficacy and safety of BLB implant for immediate implantation and delayed implantation. METHODS:Eighty patients undergoing denture implantation and restoration, 35 males and 45 females, aged 20-52 years were equaly divided into research group treated with immediate implantation of BLB implant and control group treated with delayed implantation. Crown restoration was completed at 3 months after implantation. Then, the patients were folowed up for 6 months to observe the implant stability, implantation efficacy and adverse effects. RESULTS AND CONCLUSION:There was no intra-group or intergroup difference in the implant stability quotients of two groups at 1, 3, 6 months after restoration (P> 0.05). The total effective rate was 95% in the research group and 90% in the control group, and there was no significant difference between the two groups (P > 0.05). In the research group, there was one case of gingivitis and one case of lower lip numbness; in the control group, there were two cases of wound infection and one case of lower lip numbness, but there was no difference in the incidence of complications between the two groups (P > 0.05). These findings indicate that BLB implant has good efficacy and safety both in immediate implantation and delayed implantation.

Objective:To screen auramine O in Guci tablets. Methods:Auramine O was detected by HPLC method on a Diamon-sil-C18(250mm×4.6mm,5μm)columnwiththemobilephaseofacetonitrile-0.025mol·L-1monopotassiumphosphatebuffersolu-tion(containing 0. 2% triethylamine,adjusting pH to 3. 0 with phosphoric acid)(36∶65)at the flow rate of 0. 8 ml·min-1. The detec-tion wavelength was 432 nm and the column temperature was 35℃. Results:The LOD of auramine O was 0. 05ng. Among 45 batches of tested samples, auramine O was found in seven ones. Conclusion:The method is simple, rapid and accurate, which can guarantee the drug safety of Guci tablets.

Objective To explore the value of hepcidin measurement in differential diagnosis of iron deficiency anemia(IDA) and anemia of chronic diseases(ACD) .Methods Serum hepcidin was measured by using ELISA .Serum iron(SI) and total iron binding capacity(TIBC) were determined by using Ferro zine colorimetric method .Results Hepcidin expression increased in ACD group (P<0 .05) ,but decreased in IDA group(P<0 .05) .The area under the curve of ROC for hepcidin ,SI and TIBC were 0 .97 ,0 .66 and 0 .85 respectively .Conclusion Hepcidin is a simple and safe indicator in differential diagnosis of IDA and ACD ,and its diagnos-tic accuracy is better than SI and TIBC .

Objective To investigate the therapeutic effect of distal radius fractures operation.Methods Eighty distal radius fractures patients who were treated from January 2010 to January 2011 were divided into observation group and control group by random digits table method,each group had 40 cases.The observation group was treated with plate internal fixation,the control group took closed reduction and splint external fixation.The palmar tilt,radial ulnar deviation,axial shortening before treatment and after treatment for 3 months were compared between two groups.The clinical curative effect after treatment for 1 year was compared.Results The palmar tilt,radial ulnar deviation,axial shortening before treatment between two groups had no significant difference (P ＞ 0.05).After treatment for 3 months,the palmar tilt,radial ulnar deviation,axial shortening in observation group were (17.0 ± 1.6)°,(23.0 ± 2.1)°,(1.0 ± 0.2) mm,in control group were (4.0 ± 0.8)°,(10.0 ± 1.1)°,(4.0 ± 1.1) mm,there was significant difference(P＜ 0.05).After treatment for 1 year,the excellent and good rate in observation group was 90.0％(36/40),significantly higher than that in control group [50.0％ (20/40)] (P ＜ 0.05).Conclusion Plate internal fixation in the treatment of distal radius fractures is more conductive to the wrist recovery of joint structure and function,reduce the occurrence of wrist joint dysfunction,improve the quality of life,and is worth to be applied in clinic.

The development of cancer gene vaccineis gradually maturing,common genes mainly include cytokine gene vaccines,multi-gene combined vaccines,gene-transfered dendritic cell vaccines,and so on.In re-cent years the development of cancer gene vaccines gradually tend toward looking for gene vaccine adjuvants,or exploration of the combination of different genes to achieve a more effective therapeutic purposes.

ObjectiveTo explore salivary concentration of carcinoembryonic antigen (CEA),interleukin (IL)-6,IL-8 in oral squamous cell carcinoma and its' clinical significance.MethodsForty-two cases with oral squamous cell carcinoma were selected as experience group and 50 healthy persons as control group.ELISA method was performed to detect CEA,IL-6,IL-8 level of salivary and serum in two groups.ResultsThe salivary concentration of CEA,IL-6 and IL-8 was (62.37 ± 20.80)μ g/L,(79.12 ± 30.26)ng/L,( 834.61 ± 231.85 ) ng/L respectively in experience group,(25.72 ± 12.65 ) μ g/L,(0.58 ± 0.25 ) ng/L,(209.71 ± 67.92) ng/L in control group.There was significant difference between two groups(P＜ 0.01 ).The serum concentration of CEA,IL-6 and IL-8 was(61.15 ± 23.69)μ g/L,(58.17 ± 12.83) ng/L,(852.31 ±172.97) ng/L respectively in experience group,and IL-6 level of serum were much lower than that of salivary (P ＜ 0.05).ConclusionsCEA,IL-6 and IL-8 can be biomarkers of oral squamous cell carcinoma.Salivary detection is an ideal auxiliary diagnosis method for its simplicity and sensitivity.